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Pharmacologic opportunities for HIV prevention.
Nicol MR, Kashuba AD. Nicol MR, et al. Clin Pharmacol Ther. 2010 Nov;88(5):598-609. doi: 10.1038/clpt.2010.189. Epub 2010 Sep 29. Clin Pharmacol Ther. 2010. PMID: 20881955 Free PMC article. Review.
Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers.
Yeh RF, Gaver VE, Patterson KB, Rezk NL, Baxter-Meheux F, Blake MJ, Eron JJ Jr, Klein CE, Rublein JC, Kashuba AD. Yeh RF, et al. J Acquir Immune Defic Syndr. 2006 May;42(1):52-60. doi: 10.1097/01.qai.0000219774.20174.64. J Acquir Immune Defic Syndr. 2006. PMID: 16639344