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Splice site m⁶A methylation prevents binding of U2AF35 to inhibit RNA splicing.

Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vågbø CB, Steiner FA, Homolka D, Pillai RS. Mendel M, et al. Cell. 2021 Jun 10;184(12):3125-3142.e25. doi: 10.1016/j.cell.2021.03.062. Epub 2021 Apr 29. Cell. 2021. PMID: 33930289 Free PMC article.

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The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels.

Zhang Q, Wang Z, Zhang W, Wen Q, Li X, Zhou J, Wu X, Guo Y, Liu Y, Wei C, Qian W, Tian Y. Zhang Q, et al. Nat Cell Biol. 2021 Aug;23(8):870-880. doi: 10.1038/s41556-021-00724-8. Epub 2021 Aug 2. Nat Cell Biol. 2021. PMID: 34341532

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ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.

Vrijsen S, Besora-Casals L, van Veen S, Zielich J, Van den Haute C, Hamouda NN, Fischer C, Ghesquière B, Tournev I, Agostinis P, Baekelandt V, Eggermont J, Lambie E, Martin S, Vangheluwe P. Vrijsen S, et al. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31198-31207. doi: 10.1073/pnas.1922342117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229544 Free PMC article.

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FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins.

Chen F, Yan B, Ren J, Lyu R, Wu Y, Guo Y, Li D, Zhang H, Hu J. Chen F, et al. J Cell Biol. 2021 May 3;220(5):e201907183. doi: 10.1083/jcb.201907183. J Cell Biol. 2021. PMID: 33861319 Free PMC article.

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H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity.

Methot SP, Padeken J, Brancati G, Zeller P, Delaney CE, Gaidatzis D, Kohler H, van Oudenaarden A, Großhans H, Gasser SM. Methot SP, et al. Nat Cell Biol. 2021 Nov;23(11):1163-1175. doi: 10.1038/s41556-021-00776-w. Epub 2021 Nov 4. Nat Cell Biol. 2021. PMID: 34737442 Free PMC article.

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Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration.

Wang C, Lau CY, Ma F, Zheng C. Wang C, et al. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2106504118. doi: 10.1073/pnas.2106504118. Proc Natl Acad Sci U S A. 2021. PMID: 34413194 Free PMC article.

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m⁶ A-mediated alternative splicing coupled with nonsense-mediated mRNA decay regulates SAM synthetase homeostasis.

Watabe E, Togo-Ohno M, Ishigami Y, Wani S, Hirota K, Kimura-Asami M, Hasan S, Takei S, Fukamizu A, Suzuki Y, Suzuki T, Kuroyanagi H. Watabe E, et al. EMBO J. 2021 Jul 15;40(14):e106434. doi: 10.15252/embj.2020106434. Epub 2021 Jun 21. EMBO J. 2021. PMID: 34152017

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Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.

Elouej S, Harhouri K, Le Mao M, Baujat G, Nampoothiri S, Kayserili H, Menabawy NA, Selim L, Paneque AL, Kubisch C, Lessel D, Rubinsztajn R, Charar C, Bartoli C, Airault C, Deleuze JF, Rötig A, Bauer P, Pereira C, Loh A, Escande-Beillard N, Muchir A, Martino L, Gruenbaum Y, Lee SH, Manivet P, Lenaers G, Reversade B, Lévy N, De Sandre-Giovannoli A. Elouej S, et al. Nat Commun. 2020 Sep 11;11(1):4589. doi: 10.1038/s41467-020-18146-9. Nat Commun. 2020. PMID: 32917887 Free PMC article.

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Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans.

Chen LT, Lin CT, Lin LY, Hsu JM, Wu YC, Pan CL. Chen LT, et al. Dev Cell. 2021 Jun 21;56(12):1770-1785.e12. doi: 10.1016/j.devcel.2021.04.021. Epub 2021 May 12. Dev Cell. 2021. PMID: 33984269

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Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.

Nowicka U, Chroscicki P, Stroobants K, Sladowska M, Turek M, Uszczynska-Ratajczak B, Kundra R, Goral T, Perni M, Dobson CM, Vendruscolo M, Chacinska A. Nowicka U, et al. Elife. 2021 Jul 20;10:e65484. doi: 10.7554/eLife.65484. Elife. 2021. PMID: 34292154 Free PMC article.

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