Abstract
A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Autoantigens / chemistry*
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Burns / metabolism*
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Complement C4 / genetics
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Complement System Proteins / metabolism*
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Homeodomain Proteins / genetics
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Immunoglobulin M / chemistry
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Inflammation
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Peptides / chemistry
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Wound Healing*
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Wound Infection
Substances
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Autoantigens
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Complement C4
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Homeodomain Proteins
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Immunoglobulin M
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Peptides
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RAG-1 protein
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Complement System Proteins