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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 1
2001 4
2002 4
2003 21
2004 36
2005 30
2006 30
2007 36
2008 43
2009 52
2010 59
2011 43
2012 58
2013 58
2014 45
2015 49
2016 36
2017 43
2018 42
2019 35
2020 37
2021 37
2022 28
2023 23
2024 9

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760 results

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Page 1
Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease.
Chen J, Ruan X, Sun Y, Lu S, Hu S, Yuan S, Li X. Chen J, et al. EBioMedicine. 2024 Jan;99:104934. doi: 10.1016/j.ebiom.2023.104934. Epub 2023 Dec 16. EBioMedicine. 2024. PMID: 38103512 Free PMC article.
FINDINGS: After integrating the multi-omics data between mQTL-eQTL and eQTL-pQTL, we identified two mitochondrial genes, i.e., PARK7 and ACADM, with tier 1 evidence for their associations with IBD and ulcerative colitis (UC). ...INTERPRETATION: We found that the mit …
FINDINGS: After integrating the multi-omics data between mQTL-eQTL and eQTL-pQTL, we identified two mitochondrial genes, i.e., PAR
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite.
Heremans IP, Caligiore F, Gerin I, Bury M, Lutz M, Graff J, Stroobant V, Vertommen D, Teleman AA, Van Schaftingen E, Bommer GT. Heremans IP, et al. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2111338119. doi: 10.1073/pnas.2111338119. Proc Natl Acad Sci U S A. 2022. PMID: 35046029 Free PMC article.
As a consequence, inactivation of PARK7 (or its orthologs) in human cell lines, mouse brain, and Drosophila melanogaster leads to the accumulation of these damaged compounds, most of which have not been described before. Our work demonstrates that PARK7 function rep …
As a consequence, inactivation of PARK7 (or its orthologs) in human cell lines, mouse brain, and Drosophila melanogaster leads to the …
Juvenile parkinsonism: Differential diagnosis, genetics, and treatment.
Niemann N, Jankovic J. Niemann N, et al. Parkinsonism Relat Disord. 2019 Oct;67:74-89. doi: 10.1016/j.parkreldis.2019.06.025. Epub 2019 Jun 30. Parkinsonism Relat Disord. 2019. PMID: 31272925 Review.
Levodopa-responsive juvenile parkinsonism that is consistent with diagnostic criteria for Parkinson's disease is most often caused by mutations in the PARK-Parkin, PARK-PINK1, or PARK-DJ1 genes. However, many other genetic and acquired parkinsonian disorders presenting in …
Levodopa-responsive juvenile parkinsonism that is consistent with diagnostic criteria for Parkinson's disease is most often caused by mutati …
DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy.
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, Eggermont K, Madeiro RF, Sue C, Verfaillie C, Vandenberghe W. Imberechts D, et al. Brain. 2022 Dec 19;145(12):4368-4384. doi: 10.1093/brain/awac313. Brain. 2022. PMID: 36039535 Free PMC article.
Loss-of-function mutations in the PRKN, PINK1 and PARK7 genes (encoding parkin, PINK1 and DJ-1, respectively) cause autosomal recessive forms of Parkinson's disease. ...Here, we investigated PINK1/parkin-mediated mitophagy in cultured human fibroblasts and induced p …
Loss-of-function mutations in the PRKN, PINK1 and PARK7 genes (encoding parkin, PINK1 and DJ-1, respectively) cause autosomal …
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing.
Danileviciute E, Zeng N, Capelle CM, Paczia N, Gillespie MA, Kurniawan H, Benzarti M, Merz MP, Coowar D, Fritah S, Vogt Weisenhorn DM, Gomez Giro G, Grusdat M, Baron A, Guerin C, Franchina DG, Léonard C, Domingues O, Delhalle S, Wurst W, Turner JD, Schwamborn JC, Meiser J, Krüger R, Ranish J, Brenner D, Linster CL, Balling R, Ollert M, Hefeng FQ. Danileviciute E, et al. Nat Metab. 2022 May;4(5):589-607. doi: 10.1038/s42255-022-00576-y. Epub 2022 May 26. Nat Metab. 2022. PMID: 35618940
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson's disease gene) is a pacemaker regulating PDH activity in CD4(+) regulatory T cells (T(reg) …
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded b …
Pathogenesis of DJ-1/PARK7-Mediated Parkinson's Disease.
Skou LD, Johansen SK, Okarmus J, Meyer M. Skou LD, et al. Cells. 2024 Feb 6;13(4):296. doi: 10.3390/cells13040296. Cells. 2024. PMID: 38391909 Free PMC article. Review.
Parkinson's disease (PD) is a common movement disorder associated with the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mutations in the PD-associated gene PARK7 alter the structure and function of the encoded protein DJ-1, and the res …
Parkinson's disease (PD) is a common movement disorder associated with the degeneration of dopaminergic neurons in the substantia nigra pars …
Gene-based burden analysis of damaging private variants in PRKN, PARK7 and PINK1 in Parkinson's disease cohorts of European descent.
Hu J, Waters CH, Spiegelman D, Fon EA, Yu E, Asayesh F, Krohn L, Saini P, Alcalay RN, Hassin-Baer S, Gan-Or Z, Krainc D, Zhang B, Bustos BI, Lubbe SJ; International Parkinson's Disease Genomics Consortium (IPDGC). Hu J, et al. Neurobiol Aging. 2022 Nov;119:136-138. doi: 10.1016/j.neurobiolaging.2022.07.012. Epub 2022 Jul 31. Neurobiol Aging. 2022. PMID: 36305379
Recessive mutations in PRKN, PARK7, and PINK1 are established causes of early-onset Parkinson's disease (EOPD). ...Here, we assessed heterozygous private PRKN, PARK7 and PINK1 variants in PD risk in four large-scale PD case-control datasets by performing gene
Recessive mutations in PRKN, PARK7, and PINK1 are established causes of early-onset Parkinson's disease (EOPD). ...Here, we assessed …
DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders.
Hijioka M, Inden M, Yanagisawa D, Kitamura Y. Hijioka M, et al. Biol Pharm Bull. 2017;40(5):548-552. doi: 10.1248/bpb.b16-01006. Biol Pharm Bull. 2017. PMID: 28458339 Free article. Review.
DJ-1, encoded in a causative gene of familial Parkinson's disease (PARK7), has multiple functions: it works as an antioxidant, in transcriptional regulation, as a molecular chaperone and in protein degradation. ...
DJ-1, encoded in a causative gene of familial Parkinson's disease (PARK7), has multiple functions: it works as an antioxidant, …
Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.
Chin HY, Lardelli M, Collins-Praino L, Barthelson K. Chin HY, et al. Mol Brain. 2021 May 24;14(1):83. doi: 10.1186/s13041-021-00792-9. Mol Brain. 2021. PMID: 34030724 Free PMC article.
Mutation of the gene PARK7 (DJ1) causes monogenic autosomal recessive Parkinson's disease (PD) in humans. ...Homozygous mutants for the PARK7-orthologous genes in zebrafish, park7, show changes to gene expression in the oxidative phosphor …
Mutation of the gene PARK7 (DJ1) causes monogenic autosomal recessive Parkinson's disease (PD) in humans. ...Homozygous mutant …
760 results