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Year Number of Results
2005 1
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91 results

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Page 1
The role of Pcdh10 in neurological disease and cancer.
Zhen Y, Pavez M, Li X. Zhen Y, et al. J Cancer Res Clin Oncol. 2023 Aug;149(10):8153-8164. doi: 10.1007/s00432-023-04743-w. Epub 2023 Apr 14. J Cancer Res Clin Oncol. 2023. PMID: 37058252 Free PMC article. Review.
Protocadherin 10 plays a critical role in the central nervous system including in cell adhesion, formation and maintenance of neural circuits and synapses, regulation of actin assembly, cognitive function and tumor suppression. Additionally, Pcdh10 can serve as a non-invas …
Protocadherin 10 plays a critical role in the central nervous system including in cell adhesion, formation and maintenance of neural circuit …
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P. Qu Y, et al. Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Clin Chim Acta. 2013. PMID: 23669186 Free article. Review.
Gastric cancer is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide. ...Aberrant DNA methylation in the promoter regions of gene, which leads to inactivation of tumor suppressor and other cancer-related …
Gastric cancer is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide. …
PCDH10 exerts tumor-suppressor functions through modulation of EGFR/AKT axis in colorectal cancer.
Jao TM, Fang WH, Ciou SC, Yu SL, Hung YL, Weng WT, Lin TY, Tsai MH, Yang YC. Jao TM, et al. Cancer Lett. 2021 Feb 28;499:290-300. doi: 10.1016/j.canlet.2020.11.017. Epub 2020 Nov 30. Cancer Lett. 2021. PMID: 33271263
Protocadherin 10 (PCDH10) is identified as a tumor suppressor in multiple cancers. The molecular mechanisms that mediate the functions of PCDH10 have yet to be fully elucidated. Here, we demonstrated that ectopic expression of PCDH10 in colorectal c …
Protocadherin 10 (PCDH10) is identified as a tumor suppressor in multiple cancers. The molecular mechanisms that mediate the f …
Circular RNA PCDH10 regulates the tumorigenesis of pancreatic cancer through the miR-338-3p/hTERT axis.
Zhang S, Qiu M, Gao S, Tian T. Zhang S, et al. Am J Transl Res. 2021 Apr 15;13(4):2181-2197. eCollection 2021. Am J Transl Res. 2021. PMID: 34017382 Free PMC article.
Protocadherin-10 (PCDH10) was previously identified as a pancreatic cancer (PC) suppressor by reducing telomerase activity through binding with human telomerase reverse transcriptase (hTERT). However, we did not observe any effects of PCDH10 on hTERT mRNA or …
Protocadherin-10 (PCDH10) was previously identified as a pancreatic cancer (PC) suppressor by reducing telomerase activity thr …
E3 ubiquitin ligase RNF180 prevents excessive PCDH10 methylation to suppress the proliferation and metastasis of gastric cancer cells by promoting ubiquitination of DNMT1.
Zhang N, Gao X, Yuan Q, Fu X, Wang P, Cai F, Liu H, Zhang J, Liang H, Nie Y, Deng J. Zhang N, et al. Clin Epigenetics. 2023 May 5;15(1):77. doi: 10.1186/s13148-023-01492-y. Clin Epigenetics. 2023. PMID: 37147733 Free PMC article.
BACKGROUND: Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including gastric cancer (GC). Protocadherin 10 (PCDH …
BACKGROUND: Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contribute …
Role of PCDH10 and its hypermethylation in human gastric cancer.
Li Z, Chim JC, Yang M, Ye J, Wong BC, Qiao L. Li Z, et al. Biochim Biophys Acta. 2012 Feb;1823(2):298-305. doi: 10.1016/j.bbamcr.2011.11.011. Epub 2011 Dec 20. Biochim Biophys Acta. 2012. PMID: 22206871 Free article.
However, the role of PCDH10 in gastric cancer is largely unknown. In this study, we examined the expression and methylation status of PCDH10 in gastric cancer cells and tissues by real time PCR and methylation-specific PCR (MSP), and then investigated …
However, the role of PCDH10 in gastric cancer is largely unknown. In this study, we examined the expression and methylation st …
Prognostic Value of Protocadherin10 (PCDH10) Methylation in Serum of Prostate Cancer Patients.
Deng QK, Lei YG, Lin YL, Ma JG, Li WP. Deng QK, et al. Med Sci Monit. 2016 Feb 16;22:516-21. doi: 10.12659/msm.897179. Med Sci Monit. 2016. PMID: 26881880 Free PMC article.
Kaplan-Meier survival analysis and Cox analysis were used to evaluate the correlation between PCDH10 methylation and prognosis. RESULTS PCDH10 methylation occurred frequently in serum of prostate cancer patients. ...CONCLUSIONS PCDH10 methylation in se …
Kaplan-Meier survival analysis and Cox analysis were used to evaluate the correlation between PCDH10 methylation and prognosis. RESUL …
Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR-576-5p/PCDH10 axis.
Zhou J, Wang L, Sun Q, Chen R, Zhang C, Yang P, Tan Y, Peng C, Wang T, Jin C, Ji J, Jin K, Sun Y. Zhou J, et al. Clin Transl Med. 2021 Nov;11(11):e565. doi: 10.1002/ctm2.565. Clin Transl Med. 2021. PMID: 34841662 Free PMC article.
Moreover, the mechanistic study showed that hsa_circ_0001666, acting as 'ceRNA' of miR-576-5p, prevented PCDH10 downregulation, as well as suppressed EMT and stemness of CRC cells, and the Wnt/beta-catenin signalling pathway. Inhibiting miR-576-5p or overexpressing PCDH …
Moreover, the mechanistic study showed that hsa_circ_0001666, acting as 'ceRNA' of miR-576-5p, prevented PCDH10 downregulation, as we …
Angelica sinensis polysaccharide suppresses the Wnt/beta-catenin-mediated malignant biological behaviors of breast cancer cells via the miR-3187-3p/PCDH10 axis.
Cai Y, Wang Y, Su W, Zhou X, Lu C. Cai Y, et al. Biochem Pharmacol. 2024 Jul;225:116295. doi: 10.1016/j.bcp.2024.116295. Epub 2024 May 16. Biochem Pharmacol. 2024. PMID: 38762145
Breast cancer (BC) is one of the most common malignant tumors in women. Angelica sinensis polysaccharide (ASP) is one of the main components extracted from the traditional Chinese medicine Angelica sinensis. Research has shown that ASP affects the progression of various …
Breast cancer (BC) is one of the most common malignant tumors in women. Angelica sinensis polysaccharide (ASP) is one of the main com …
Epigenetic inactivation of PCDH10 in human prostate cancer cell lines.
Li Z, Li W, Xie J, Wang Y, Tang A, Li X, Ye J, Gui Y, Cai Z. Li Z, et al. Cell Biol Int. 2011 Jul;35(7):671-6. doi: 10.1042/CBI20100568. Cell Biol Int. 2011. PMID: 21314642
Here, we investigated the expression of PCDH10 in different normal adult tissues and in a panel of prostate cancer cell lines. ...Decreased PCDH10 expression was correlated with the methylation status of the PCDH10 promoter. Furthermore, the DNA demeth …
Here, we investigated the expression of PCDH10 in different normal adult tissues and in a panel of prostate cancer cell lines. …
91 results