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Page 1
PDE isoenzymes as targets for anti-asthma drugs.
Schudt C, Tenor H, Hatzelmann A. Schudt C, et al. Eur Respir J. 1995 Jul;8(7):1179-83. doi: 10.1183/09031936.95.08071179. Eur Respir J. 1995. PMID: 7589403 Free article. Review.
Lymphocytes, alveolar macrophages and endothelial cells contain PDE IV and PDE III, and in addition, PDE I is measured in macrophages and PDE II in endothelial cells. These basal cell-specific PDE isoenzyme profiles appear to be modified by: 1) substra …
Lymphocytes, alveolar macrophages and endothelial cells contain PDE IV and PDE III, and in addition, PDE I is measured in macr …
Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. I. Identification and characterization.
Truss MC, Uckert S, Stief CG, Kuczyk M, Jonas U. Truss MC, et al. Urol Res. 1996;24(3):123-8. doi: 10.1007/BF00304074. Urol Res. 1996. PMID: 8839478
All five presently known PDE isoenzyme families were identified: one high-affinity, low-Km calcium/calmodulin-stimulated PDE I with a slight preference for cGMP over cAMP, one cGMP-stimulated PDE II, one cGMP-inhibited PDE III, one cAMP-specific PDE IV …
All five presently known PDE isoenzyme families were identified: one high-affinity, low-Km calcium/calmodulin-stimulated PDE I …
Cyclic adenosine 3':5'-monophosphate phosphodiesterase and its role in learning in Drosophila.
Shotwell SL. Shotwell SL. J Neurosci. 1983 Apr;3(4):739-47. doi: 10.1523/JNEUROSCI.03-04-00739.1983. J Neurosci. 1983. PMID: 6300356 Free PMC article.
A micro-assay technique is described that allows the separate measurement of PDE I and PDE II in crude extracts, based on specific inhibition of PDE I [3H]cAMP hydrolysis by cGMP. ...Biochemical and genetic experiments fail to reveal any …
A micro-assay technique is described that allows the separate measurement of PDE I and PDE II in crude extracts, …
Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation.
Meskini N, Némoz G, Okyayuz-Baklouti I, Lagarde M, Prigent AF. Meskini N, et al. Biochem Pharmacol. 1994 Mar 2;47(5):781-8. doi: 10.1016/0006-2952(94)90477-4. Biochem Pharmacol. 1994. PMID: 8135854
HPLC on a Mono Q ion-exchange column resolved four separate cyclic nucleotide PDE activities: a calmodulin-activated fraction (PDE I), a cGMP-stimulated fraction (PDE II), a cAMP-specific rolipram-sensitive fraction (PDE IV) and a cGMP-inhibited fracti …
HPLC on a Mono Q ion-exchange column resolved four separate cyclic nucleotide PDE activities: a calmodulin-activated fraction (PDE …
Cyclic nucleotide phosphodiesterase isoenzyme activities in human alveolar macrophages.
Tenor H, Hatzelmann A, Kupferschmidt R, Stanciu L, Djukanović R, Schudt C, Wendel A, Church MK, Shute JK. Tenor H, et al. Clin Exp Allergy. 1995 Jul;25(7):625-33. doi: 10.1111/j.1365-2222.1995.tb01110.x. Clin Exp Allergy. 1995. PMID: 8521181
PDE isoenzyme activity profiles were investigated using isoenzyme selective inhibitors and activators. RESULTS: In macrophages substantial PDE I activity, which was significantly higher than PDE III-V activity was detected and PDE II was absent. PDE II …
PDE isoenzyme activity profiles were investigated using isoenzyme selective inhibitors and activators. RESULTS: In macrophages substantial …
Zardaverine as a selective inhibitor of phosphodiesterase isozymes.
Schudt C, Winder S, Müller B, Ukena D. Schudt C, et al. Biochem Pharmacol. 1991 Jun 21;42(1):153-62. doi: 10.1016/0006-2952(91)90694-z. Biochem Pharmacol. 1991. PMID: 1648920
The pyridazinone derivative affected the calmodulin-stimulated PDE I, the cyclic GMP-stimulated PDE II and the cyclic GMP-specific PDE V only marginally at concentrations up to 100 microM. ...
The pyridazinone derivative affected the calmodulin-stimulated PDE I, the cyclic GMP-stimulated PDE II and the c …
Study of the interaction between different phosphodiesterases and yessotoxin using a resonant mirror biosensor.
Pazos MJ, Alfonso A, Vieytes MR, Yasumoto T, Botana LM. Pazos MJ, et al. Chem Res Toxicol. 2006 Jun;19(6):794-800. doi: 10.1021/tx0503303. Chem Res Toxicol. 2006. PMID: 16780358
We use aminosilane cuvettes, where exonuclease Phosphodiesterase I from Crotalus atrox (PDE I), exonuclease Phosphodiesterase II from bovine spleen (PDE II), or phosphodiesterase 3',5'-cyclic-nucleotide-specific from bovine brain (PDEs) are immobilized …
We use aminosilane cuvettes, where exonuclease Phosphodiesterase I from Crotalus atrox (PDE I), exonuclease Phosphodiesterase …
Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue.
Price B, Pyne NJ, Houslay MD. Price B, et al. Biochem Pharmacol. 1987 Dec 1;36(23):4047-54. doi: 10.1016/0006-2952(87)90560-0. Biochem Pharmacol. 1987. PMID: 2825712
The relative ratio of cyclic AMP phosphodiesterase activity exhibited by these three peaks was 1:0.65:0.82 and of cyclic GMP phosphodiesterase activity was 1:0.52:0.05 for PDE-I, PDE-II and PDE-III respectively. PDE-II and PDE-III were fu …
The relative ratio of cyclic AMP phosphodiesterase activity exhibited by these three peaks was 1:0.65:0.82 and of cyclic GMP phosphodiestera …
Comparison of cyclic nucleotide phosphodiesterase isoenzymes in rat and rabbit ventricular myocardium: positive inotropic and phosphodiesterase inhibitory effects of Org 30029, milrinone and rolipram.
Shahid M, Nicholson CD. Shahid M, et al. Naunyn Schmiedebergs Arch Pharmacol. 1990 Dec;342(6):698-705. doi: 10.1007/BF00175715. Naunyn Schmiedebergs Arch Pharmacol. 1990. PMID: 1710786
In rabbit papillary muscles, the positive inotropic action of milrinone was markedly potentiated by rolipram. Four main types of PDE (I, II, III, IV) isoenzymes were resolved, by DEAE-sepharose or Mono-Q ion-exchange chromatography, from both rat and rabbit cardiac …
In rabbit papillary muscles, the positive inotropic action of milrinone was markedly potentiated by rolipram. Four main types of PDE …
Formation of reactive oxygen metabolites in glomeruli is suppressed by inhibition of cAMP phosphodiesterase isozyme type IV.
Chini CC, Chini EN, Williams JM, Matousovic K, Dousa TP. Chini CC, et al. Kidney Int. 1994 Jul;46(1):28-36. doi: 10.1038/ki.1994.241. Kidney Int. 1994. PMID: 7933846 Free article.
Glomeruli have the capacity to hydrolyze cAMP by isozymes PDE-II, PDE-III and PDE-IV, whereas cGMP is hydrolyzed by PDE-I and PDE-V. Inhibitor of PDE-IV rolipram inhibited significantly (cca 40 to 50%) ROM generation in response to stimulation by phorb …
Glomeruli have the capacity to hydrolyze cAMP by isozymes PDE-II, PDE-III and PDE-IV, whereas cGMP is hydrolyzed by PDE …
49 results