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3,679 results

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Page 1
Patient-Derived Variants Define Constraints for Ligand Binding at the PDZ Domain of CASK.
Tibbe D, Hönck HH, Bhatia N, Truong T, Proskauer L, Ortiz-Gonzalez X, Maguire JA, Pak C, Kreienkamp HJ. Tibbe D, et al. J Neurochem. 2025 Dec;169(12):e70303. doi: 10.1111/jnc.70303. J Neurochem. 2025. PMID: 41321276 Free PMC article.
Structural analyses of related MAGUKs indicate that the canonical SH3 and GK domains combine with the PDZ domain to form the so-called PSG supramodule. Conserved aromatic residues (Y723 and W914) flanking the GK domain contribute to the formation of a …
Structural analyses of related MAGUKs indicate that the canonical SH3 and GK domains combine with the PDZ domain to for …
Three Binding Conformations of BIO124 in the Pocket of the PICK1 PDZ Domain.
Stevens AO, Luo S, He Y. Stevens AO, et al. Cells. 2022 Aug 7;11(15):2451. doi: 10.3390/cells11152451. Cells. 2022. PMID: 35954295 Free PMC article.
The PICK1 PDZ domain has been proposed as a possible drug target because the interactions between the PICK1 PDZ domain and the GluA2 subunit of the AMPA receptor have been shown to progress neurodegenerative diseases. ...We propose that a physically la …
The PICK1 PDZ domain has been proposed as a possible drug target because the interactions between the PICK1 PDZ doma …
The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins.
Cha B, Donowitz M. Cha B, et al. Clin Exp Pharmacol Physiol. 2008 Aug;35(8):863-71. doi: 10.1111/j.1440-1681.2008.04931.x. Epub 2008 Apr 21. Clin Exp Pharmacol Physiol. 2008. PMID: 18430067 Review.
In addition, NHE3 binds indirectly to ezrin. The PDZ domain-containing proteins Na(+)/H(+) exchanger regulatory factor (NHERF) 1 and NHERF2, as intermediates in linking NHE3 to ezrin, are necessary for many aspects of NHE3 regulation. The binding of NH …
In addition, NHE3 binds indirectly to ezrin. The PDZ domain-containing proteins Na(+)/H(+) exchanger regulatory factor …
A class III ligand oscillates between internal and terminal binding modes as it engages with the Dishevelled PDZ domain.
Kumar J, Micka M, Komárek J, Klumpler T, Bystrý V, Sprangers R, Bařinka C, Bryja V, Tripsianes K. Kumar J, et al. Structure. 2025 Aug 7;33(8):1362-1373.e5. doi: 10.1016/j.str.2025.05.012. Epub 2025 Jun 13. Structure. 2025. PMID: 40516532
One of the largest domain-motif interactomes in human involves PSD-95/Discs-large/ZO-1 (PDZ) domains. The framework for understanding the PDZ interactome is well established; however the functional dynamics associated with PDZ-ligand interaction …
One of the largest domain-motif interactomes in human involves PSD-95/Discs-large/ZO-1 (PDZ) domains. The framework for …
Phosphoinositides and PDZ domain scaffolds.
Wawrzyniak AM, Kashyap R, Zimmermann P. Wawrzyniak AM, et al. Adv Exp Med Biol. 2013;991:41-57. doi: 10.1007/978-94-007-6331-9_4. Adv Exp Med Biol. 2013. PMID: 23775690 Review.
Confirmatory studies and a series of functional follow-ups established PDZ domains as dual specificity modules displaying both peptide and lipid binding, and prompted a rethinking of the mode of action of PDZ domains in the control of cell signa …
Confirmatory studies and a series of functional follow-ups established PDZ domains as dual specificity modules displaying both …
Tight junction formation by a claudin mutant lacking the COOH-terminal PDZ domain-binding motif.
Fujiwara S, Nguyen TP, Furuse K, Fukazawa Y, Otani T, Furuse M. Fujiwara S, et al. Ann N Y Acad Sci. 2022 Oct;1516(1):85-94. doi: 10.1111/nyas.14881. Epub 2022 Aug 9. Ann N Y Acad Sci. 2022. PMID: 35945631 Free PMC article.
To address the role of the ZO proteins binding to claudins at TJs, a COOH-terminal PDZ domain binding motif-deleted claudin-3 mutant, which lacks the ZO protein binding, was stably expressed in claudin-deficient MDCK cells. ...
To address the role of the ZO proteins binding to claudins at TJs, a COOH-terminal PDZ domain binding motif-dele …
Binding of PICK1 PDZ domain with calcineurin B regulates osteoclast differentiation.
Kamano Y, Watanabe J, Iida T, Kondo T, Okawa H, Yatani H, Saeki M, Egusa H. Kamano Y, et al. Biochem Biophys Res Commun. 2018 Jan 29;496(1):83-88. doi: 10.1016/j.bbrc.2017.12.173. Epub 2018 Jan 3. Biochem Biophys Res Commun. 2018. PMID: 29305867
The interaction of PICK1 with calcineurin B in BMMs was confirmed by co-immunoprecipitation. An inhibitor of the PICK1 PDZ domain significantly decreased osteoclastogenesis marker gene expression and the number of TRAP-positive multinucleated cells among RAW264.7 os …
The interaction of PICK1 with calcineurin B in BMMs was confirmed by co-immunoprecipitation. An inhibitor of the PICK1 PDZ domain …
Structural basis for NHERF1 PDZ domain binding.
Mamonova T, Kurnikova M, Friedman PA. Mamonova T, et al. Biochemistry. 2012 Apr 10;51(14):3110-20. doi: 10.1021/bi201213w. Epub 2012 Mar 27. Biochemistry. 2012. PMID: 22429102 Free PMC article.
The Na(+)/H(+) exchange regulatory factor-1 (NHERF1) is a scaffolding protein that possesses two tandem PDZ domains and a carboxy-terminal ezrin-binding domain (EBD). The parathyroid hormone receptor (PTHR), type II sodium-dependent phosphate cotranspo …
The Na(+)/H(+) exchange regulatory factor-1 (NHERF1) is a scaffolding protein that possesses two tandem PDZ domains and a carb …
Computational Design of PDZ-Peptide Binding.
Panel N, Villa F, Opuu V, Mignon D, Simonson T. Panel N, et al. Methods Mol Biol. 2021;2256:237-255. doi: 10.1007/978-1-0716-1166-1_14. Methods Mol Biol. 2021. PMID: 34014526
This chapter describes two computational methods for PDZ-peptide binding: high-throughput computational protein design (CPD) and a medium-throughput approach combining molecular dynamics for conformational sampling with a Poisson-Boltzmann (PB) Linear Interaction En …
This chapter describes two computational methods for PDZ-peptide binding: high-throughput computational protein design (CPD) a …
PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.
Sotelo NS, Schepens JT, Valiente M, Hendriks WJ, Pulido R. Sotelo NS, et al. Methods. 2015 May;77-78:147-56. doi: 10.1016/j.ymeth.2014.10.017. Epub 2014 Oct 22. Methods. 2015. PMID: 25448478
The tumor suppressor PTEN possesses a C-terminal PDZ-binding motif (PDZ-BM) that is recognized by a specific set of PDZ domains from scaffolding and regulatory proteins. Here, we review the current knowledge on PTEN-PDZ domain inte …
The tumor suppressor PTEN possesses a C-terminal PDZ-binding motif (PDZ-BM) that is recognized by a specific set of …
3,679 results