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Page 1
Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice.
Lama A, Pirozzi C, Severi I, Morgese MG, Senzacqua M, Annunziata C, Comella F, Del Piano F, Schiavone S, Petrosino S, Mollica MP, Diano S, Trabace L, Calignano A, Giordano A, Mattace Raso G, Meli R. Lama A, et al. Brain Behav Immun. 2022 May;102:110-123. doi: 10.1016/j.bbi.2022.02.008. Epub 2022 Feb 14. Brain Behav Immun. 2022. PMID: 35176443 Free PMC article.
In the amygdala, PEA increased dopamine turnover, as well as GABA levels. PEA also counteracted the overactivation of HPA axis, reducing the expression of hypothalamic corticotropin-releasing hormone and its type 1 receptor. ...This finding, together with the reduce …
In the amygdala, PEA increased dopamine turnover, as well as GABA levels. PEA also counteracted the overactivation of HPA axis …
Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity.
Petrosino S, Schiano Moriello A, Verde R, Allarà M, Imperatore R, Ligresti A, Mahmoud AM, Peritore AF, Iannotti FA, Di Marzo V. Petrosino S, et al. J Neuroinflammation. 2019 Dec 26;16(1):274. doi: 10.1186/s12974-019-1671-5. J Neuroinflammation. 2019. PMID: 31878942 Free PMC article.
Here, we report novel molecular mechanisms through which PEA controls mast cell degranulation and substance P (SP)-induced histamine release in rat basophilic leukemia (RBL-2H3) cells, a mast cell model. ...CONCLUSIONS: Activation of CB2 …
Here, we report novel molecular mechanisms through which PEA controls mast cell degranulation and substance P (SP)-indu …
Impaired Duodenal Palmitoylethanolamide Release Underlies Acid-Induced Mast Cell Activation in Functional Dyspepsia.
Sarnelli G, Pesce M, Seguella L, Lu J, Efficie E, Tack J, Elisa De Palma FD, D'Alessandro A, Esposito G. Sarnelli G, et al. Cell Mol Gastroenterol Hepatol. 2021;11(3):841-855. doi: 10.1016/j.jcmgh.2020.10.001. Epub 2020 Oct 14. Cell Mol Gastroenterol Hepatol. 2021. PMID: 33065341 Free PMC article.
METHODS: Duodenal biopsy specimens from FD and control subjects, and peroxisome proliferator-activated receptor-alpha (PPARalpha) null mice were cultured at a pH of 3.0 and 7.4. Mast cell (MC) number, the release of their mediators, and the expression of transient r …
METHODS: Duodenal biopsy specimens from FD and control subjects, and peroxisome proliferator-activated receptor-alpha (PPARalpha) null mice …
Palmitoylethanolamide regulates development of intestinal radiation injury in a mast cell-dependent manner.
Wang J, Zheng J, Kulkarni A, Wang W, Garg S, Prather PL, Hauer-Jensen M. Wang J, et al. Dig Dis Sci. 2014 Nov;59(11):2693-703. doi: 10.1007/s10620-014-3212-5. Epub 2014 May 22. Dig Dis Sci. 2014. PMID: 24848354 Free PMC article.
AIM: Because endocannabinoids (eCB) regulate intestinal inflammation, we investigated the effect of the cannabimimetic, palmitoylethanolamide (PEA), in a mast competent (+/+) and mast cell-deficient (Ws/Ws) rat model. ...CONCLUSIONS: These data …
AIM: Because endocannabinoids (eCB) regulate intestinal inflammation, we investigated the effect of the cannabimimetic, palmitoylethanola …
PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia.
Parrella E, Porrini V, Iorio R, Benarese M, Lanzillotta A, Mota M, Fusco M, Tonin P, Spano P, Pizzi M. Parrella E, et al. Brain Res. 2016 Oct 1;1648(Pt A):409-417. doi: 10.1016/j.brainres.2016.07.014. Epub 2016 Jul 14. Brain Res. 2016. PMID: 27423516
PEA and luteolin pre-treatment synergistically prevented the OGD-induced degranulation of mast cells and reduced the neurotoxic potential of MC/9 cells conditioned medium. Finally, the association of the two drugs promoted a direct synergistic neuropro …
PEA and luteolin pre-treatment synergistically prevented the OGD-induced degranulation of mast cells and reduced the ne …
Neuroprotective, anti-inflammatory, and analgesic activity of palmitoylethanolamide in sickle cell mice.
Argueta DA, Avalos B, Goel Y, Tran H, Fotio Y, Piomelli D, DiPatrizio NV, Gupta K. Argueta DA, et al. Blood Adv. 2025 Jun 24;9(12):3056-3068. doi: 10.1182/bloodadvances.2024015439. Blood Adv. 2025. PMID: 40085960 Free PMC article.
PEA is a paracannabinoid lipid mediator that acts as a putative mast cell stabilizer and has been evaluated clinically for mechanical, cold, and joint pain, which are all features of SCD pain. Increased p38-MAPK activity in the spinal cord and dorsal root gan …
PEA is a paracannabinoid lipid mediator that acts as a putative mast cell stabilizer and has been evaluated clinically …
Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator.
Skaper SD, Facci L, Giusti P. Skaper SD, et al. Mol Neurobiol. 2013 Oct;48(2):340-52. doi: 10.1007/s12035-013-8487-6. Epub 2013 Jun 28. Mol Neurobiol. 2013. PMID: 23813098 Review.
Besides releasing glial and neuronal signaling molecules directed to cellular homeostasis, glia respond also to pro-inflammatory signals released from immune-related cells, with the mast cell being of particular interest. A proposed mast cell-gl …
Besides releasing glial and neuronal signaling molecules directed to cellular homeostasis, glia respond also to pro-inflammatory signals rel …
Mechanisms and clinical applications of palmitoylethanolamide (PEA) in the treatment of neuropathic pain.
Das A, Balakrishnan P. Das A, et al. Inflammopharmacology. 2025 Jan;33(1):121-133. doi: 10.1007/s10787-024-01623-8. Epub 2024 Dec 23. Inflammopharmacology. 2025. PMID: 39714723 Review.
Palmitoylethanolamide (PEA) is emerging as a promising therapeutic agent for neuropathic and other pain-related conditions. ...PEA primarily exerts its effects through interaction with its primary receptor PPAR alpha, this interaction influences pain signalli …
Palmitoylethanolamide (PEA) is emerging as a promising therapeutic agent for neuropathic and other pain-related conditions. .. …
Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats.
De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T. De Filippis D, et al. Mol Pain. 2011 Jan 10;7:3. doi: 10.1186/1744-8069-7-3. Mol Pain. 2011. PMID: 21219627 Free PMC article.
The aim of this study was to obtain evidences of a possible analgesic role for palmitoylethanolamide (PEA) in chronic granulomatous inflammation sustained by mast cell (MC) activation in rats at 96 hours. PEA (200-400-800 mug/mL), locally admini …
The aim of this study was to obtain evidences of a possible analgesic role for palmitoylethanolamide (PEA) in chronic granulom …
Palmitoylethanolamide: A Multifunctional Molecule for Neuroprotection, Chronic Pain, and Immune Modulation.
Di Stefano V, Steardo L Jr, D'Angelo M, Monaco F, Steardo L. Di Stefano V, et al. Biomedicines. 2025 May 22;13(6):1271. doi: 10.3390/biomedicines13061271. Biomedicines. 2025. PMID: 40563990 Free PMC article.
Palmitoylethanolamide (PEA) is an endogenous lipid mediator belonging to the N-acyl-ethanolamine family, widely recognized for its multifaceted effects on neuroprotection, chronic pain management, and immune modulation. ...Preclinical and clinical studies have demon …
Palmitoylethanolamide (PEA) is an endogenous lipid mediator belonging to the N-acyl-ethanolamine family, widely recognized for …
69 results