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Whole genome methylation and transcriptome analyses to identify risk for cerebral palsy (CP) in extremely low gestational age neonates (ELGAN).
Massaro AN, Bammler TK, MacDonald JW, Perez KM, Comstock B, Juul SE. Massaro AN, et al. Sci Rep. 2021 Mar 5;11(1):5305. doi: 10.1038/s41598-021-84214-9. Sci Rep. 2021. PMID: 33674671 Free PMC article.
We evaluated peripheral blood cell specimens collected during a randomized trial of erythropoietin for neuroprotection in the ELGAN (PENUT Trial, NCT# 01378273). DNA methylation data were generated from 94 PENUT subjects (n = 47 CP vs. n = 47 Control) on day 1 and 1 …
We evaluated peripheral blood cell specimens collected during a randomized trial of erythropoietin for neuroprotection in the ELGAN (PENU
Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial.
Vu PT, Ohls RK, Mayock DE, German KR, Comstock BA, Heagerty PJ, Juul SE; PENUT Consortium. Vu PT, et al. Pediatr Res. 2021 Jan 11:1-8. doi: 10.1038/s41390-020-01273-w. Online ahead of print. Pediatr Res. 2021. PMID: 33432157 Free PMC article.
We investigated the impact of transfusions on neurodevelopmental outcome in the Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial population. METHODS: This is a post hoc analysis of 936 infants 24-0/6 to 27-6/7 weeks' gestation enrolled in the PENUT Trial. …
We investigated the impact of transfusions on neurodevelopmental outcome in the Preterm Erythropoietin (Epo) Neuroprotection (PENUT) …
High-Dose Erythropoietin in Extremely Low Gestational Age Neonates Does Not Alter Risk of Retinopathy of Prematurity.
Mayock DE, Xie Z, Comstock BA, Heagerty PJ, Juul SE; Preterm Epo Neuroprotection (PENUT) Trial Consortium. Mayock DE, et al. Neonatology. 2020;117(5):650-657. doi: 10.1159/000511262. Epub 2020 Oct 28. Neonatology. 2020. PMID: 33113526
INTRODUCTION: The Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial sought to determine the safety and efficacy of early high-dose Epo as a potential neuroprotective treatment. ...METHODS: A total of 941 infants born between 24-0/7 and 27-6/7 weeks' gestation were …
INTRODUCTION: The Preterm Erythropoietin (Epo) Neuroprotection (PENUT) Trial sought to determine the safety and efficacy of early hig …
Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial.
Juul SE, Vu PT, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, O'Shea M, Rao R, Fahim N, Lampland A, Frantz ID 3rd, Khan J, Weiss M, Gilmore MM, Ohls R, Srinivasan N, Perez JE, McKay V, Heagerty PJ; Preterm Erythropoietin Neuroprotection Trial Consortium. Juul SE, et al. JAMA Pediatr. 2020 Oct 1;174(10):933-943. doi: 10.1001/jamapediatrics.2020.2271. JAMA Pediatr. 2020. PMID: 32804205 Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: The Preterm Erythropoietin Neuroprotection Trial (PENUT) is a randomized, double-masked clinical trial with participants enrolled at 19 sites consisting of 30 neonatal intensive care units across the United States. ...CONCLUSIONS AND RELE …
DESIGN, SETTING, AND PARTICIPANTS: The Preterm Erythropoietin Neuroprotection Trial (PENUT) is a randomized, double-masked clinical t …
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.
Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz Iii ID, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O'Shea TM, Hartman AL, Heagerty PJ; PENUT Trial Consortium. Juul SE, et al. N Engl J Med. 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423. N Engl J Med. 2020. PMID: 31940698 Free PMC article. Clinical Trial.
(Funded by the National Institute of Neurological Disorders and Stroke; PENUT ClinicalTrials.gov number, NCT01378273.)....
(Funded by the National Institute of Neurological Disorders and Stroke; PENUT ClinicalTrials.gov number, NCT01378273.)....
Informed consent for a neonatal clinical trial: parental experiences and perspectives.
Shah AR, Wilfond BS, Silvia A, Hancuch K, Woodrum D, Heagerty P, Ohls RK, Courtney SE, Frantz ID, Gogcu S, Bishop CE, Ahmad KA, Kathen C, Juul S; PENUT Neonatal Informed Consent Working Group. Shah AR, et al. J Perinatol. 2018 Jul;38(7):865-872. doi: 10.1038/s41372-018-0119-6. Epub 2018 May 25. J Perinatol. 2018. PMID: 29795451
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