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Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.
Bae J, Choi SP, Isono K, Lee JY, Park SW, Choi CY, Han J, Kim SH, Lee HH, Park K, Jin HY, Lee SJ, Park CG, Koseki H, Lee YS, Chun T. Bae J, et al. Nat Commun. 2019 Aug 2;10(1):3496. doi: 10.1038/s41467-019-11386-4. Nat Commun. 2019. PMID: 31375680 Free PMC article.
Here, we identify an epigenetic regulator, Phc2, as a critical modulator of HSPC trafficking. The genetic ablation of Phc2 in mice causes a severe defect in HSPC mobilization through the derepression of Vcam1 in bone marrow stromal cells (BMSCs), ultimately leading …
Here, we identify an epigenetic regulator, Phc2, as a critical modulator of HSPC trafficking. The genetic ablation of Phc2 in …
Topology and enzymatic properties of a canonical Polycomb repressive complex 1 isoform.
Colombo M, Pessey O, Marcia M. Colombo M, et al. FEBS Lett. 2019 Jul;593(14):1837-1848. doi: 10.1002/1873-3468.13442. Epub 2019 May 29. FEBS Lett. 2019. PMID: 31093962 Free PMC article.
Here, we have purified a PRC1 isoform comprising subunits RING1B, PCGF2, CBX2 and PHC2, two stable subcomplexes (RING1B-PCGF2 and RING1B-PHC2) and the catalytic subunit RING1B in isolation. ...Biochemical, biophysical, and enzymatic data suggest that CBX2 and PHC …
Here, we have purified a PRC1 isoform comprising subunits RING1B, PCGF2, CBX2 and PHC2, two stable subcomplexes (RING1B-PCGF2 and RIN …
Construct ceRNA Network and Risk Model of Breast Cancer Using Machine Learning Methods under the Mechanism of Cuproptosis.
Deng J, Fu F, Zhang F, Xia Y, Zhou Y. Deng J, et al. Diagnostics (Basel). 2023 Mar 22;13(6):1203. doi: 10.3390/diagnostics13061203. Diagnostics (Basel). 2023. PMID: 36980514 Free PMC article.
Breast cancer (BRCA) has an undesirable prognosis and is the second most common cancer among women after lung cancer. ...To this date, no studies have used machine learning methods to screen for characteristic genes to explore the role of cuproptosis-related …
Breast cancer (BRCA) has an undesirable prognosis and is the second most common cancer among women after lung cancer. . …
Androgen-induced Epigenetic Profiles of Polycomb and Trithorax Genes in Prostate Cancer Cells.
Wang S, Tailor K, Kwabi-Addo B. Wang S, et al. Anticancer Res. 2020 May;40(5):2559-2565. doi: 10.21873/anticanres.14226. Anticancer Res. 2020. PMID: 32366400 Free PMC article.
BACKGROUND/AIM: Androgens are essential for the growth of most prostate cancers (PCa). As a result, androgen ablation is the mainstay of the treatment of PCa. ...MATERIALS AND METHODS: We interrogated epigenetic changes of a 24-gene panel corresponding to polycomb and trit …
BACKGROUND/AIM: Androgens are essential for the growth of most prostate cancers (PCa). As a result, androgen ablation is the mainstay …
BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization.
Gray F, Cho HJ, Shukla S, He S, Harris A, Boytsov B, Jaremko Ł, Jaremko M, Demeler B, Lawlor ER, Grembecka J, Cierpicki T. Gray F, et al. Nat Commun. 2016 Nov 9;7:13343. doi: 10.1038/ncomms13343. Nat Commun. 2016. PMID: 27827373 Free PMC article.
Here, we present the structure of BMI1 bound to the polyhomeotic protein PHC2 illustrating that the central domain of BMI1 adopts an ubiquitin-like (UBL) fold and binds PHC2 in a beta-hairpin conformation. ...Here, we also emphasize need for joint application of NMR …
Here, we present the structure of BMI1 bound to the polyhomeotic protein PHC2 illustrating that the central domain of BMI1 adopts an …
Untying the Gordian knot of composite hemangioendothelioma: Discovery of novel fusions.
Linos K, Dermawan JK, Pulitzer M, Hameed M, Agaram NP, Agaimy A, Antonescu CR. Linos K, et al. Genes Chromosomes Cancer. 2024 Jan;63(1):e23198. doi: 10.1002/gcc.23198. Epub 2023 Sep 2. Genes Chromosomes Cancer. 2024. PMID: 37658696 Free PMC article.
Recently, a number of gene fusions including YAP1::MAML2, PTBP1::MAML2, and EPC1::PHC2 have been detected in a small subset of cases with or without neuroendocrine expression. ...
Recently, a number of gene fusions including YAP1::MAML2, PTBP1::MAML2, and EPC1::PHC2 have been detected in a small subset of cases …
Altered expression of polycomb group genes in glioblastoma multiforme.
Li G, Warden C, Zou Z, Neman J, Krueger JS, Jain A, Jandial R, Chen M. Li G, et al. PLoS One. 2013 Nov 15;8(11):e80970. doi: 10.1371/journal.pone.0080970. eCollection 2013. PLoS One. 2013. PMID: 24260522 Free PMC article.
The Polycomb group (PcG) proteins play a critical role in histone mediated epigenetics which has been implicated in the malignant evolution of glioblastoma multiforme (GBM). By systematically interrogating The Cancer Genome Atlas (TCGA), we discovered widespread aberrant e …
The Polycomb group (PcG) proteins play a critical role in histone mediated epigenetics which has been implicated in the malignant evolution …
Nicotine dose-dependent epigenomic-wide DNA methylation changes in the mice with long-term electronic cigarette exposure.
Peng G, Xi Y, Bellini C, Pham K, Zhuang ZW, Yan Q, Jia M, Wang G, Lu L, Tang MS, Zhao H, Wang H. Peng G, et al. Am J Cancer Res. 2022 Aug 15;12(8):3679-3692. eCollection 2022. Am J Cancer Res. 2022. PMID: 36119846 Free PMC article.
The other two CpGs are close to/associated with the Phc2 gene that was recently linked to smoking in a transcriptome-wide associations study. ...
The other two CpGs are close to/associated with the Phc2 gene that was recently linked to smoking in a transcriptome-wide association …
Composite hemangioendothelioma with neuroendocrine marker expression: an aggressive variant.
Perry KD, Al-Lbraheemi A, Rubin BP, Jen J, Ren H, Jang JS, Nair A, Davila J, Pambuccian S, Horvai A, Sukov W, Tazelaar HD, Folpe AL. Perry KD, et al. Mod Pathol. 2017 Nov;30(11):1589-1602. doi: 10.1038/modpathol.2017.83. Epub 2017 Jul 21. Mod Pathol. 2017. PMID: 28731049 Free article.
Aberrant expression of neuroendocrine markers is extremely rare in endothelial neoplasms, with only a single report describing three cases. Although originally classified as conventional angiosarcoma, further assessment of these tumors revealed a strikingly composite morph …
Aberrant expression of neuroendocrine markers is extremely rare in endothelial neoplasms, with only a single report describing three …
12 results