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Page 1
PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine).
[No authors listed] [No authors listed] IARC Monogr Eval Carcinog Risks Hum. 1993;56:229-42. IARC Monogr Eval Carcinog Risks Hum. 1993. PMID: 8411623 Free PMC article. Review. No abstract available.
PhIP exposure in rodents produces neuropathology potentially relevant to Alzheimer's disease.
Syeda T, Foguth RM, Llewellyn E, Cannon JR. Syeda T, et al. Toxicology. 2020 May 15;437:152436. doi: 10.1016/j.tox.2020.152436. Epub 2020 Mar 10. Toxicology. 2020. PMID: 32169473 Free PMC article.
Given the mechanistic and pathological overlap between AD and dopaminergic disorders we investigated whether exposure to 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP), a prevalent dietary HAA …
Given the mechanistic and pathological overlap between AD and dopaminergic disorders we investigated whether exposure to 2-amino …
Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development.
Zhang P, Li T, Liu C, Sindi M, Cheng X, Qi S, Liu X, Yan Y, Bao Y, Brand-Saberi B, Yang W, Wang G, Yang X. Zhang P, et al. Ann Anat. 2021 Jan;233:151617. doi: 10.1016/j.aanat.2020.151617. Epub 2020 Oct 21. Ann Anat. 2021. PMID: 33098981
BACKGROUND: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyrimidine (PhIP), one of the most abundant heterocyclic aromatic amines (HAA) formed by cooking meat at high temperatures, may modify humans and rodents through the metabolic process prior to affecting nervous system deve …
BACKGROUND: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyrimidine (PhIP), one of the most abundant heterocyclic aromatic amines (HAA) for …
A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP.
Nakagama H, Ochiai M, Ubagai T, Tajima R, Fujiwara K, Sugimura T, Nagao M. Nakagama H, et al. Mutat Res. 2002 Sep 30;506-507:137-44. doi: 10.1016/s0027-5107(02)00160-4. Mutat Res. 2002. PMID: 12351153 Review.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is one of the most abundant heterocyclic amines contained in cooked meat and fish, and induces aberrant crypt foci (ACF), putative preneoplastic les …
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is one o …
Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP-DNA adduct formation.
Lin DX, Thompson PA, Teitel C, Chen JS, Kadlubar FF. Lin DX, et al. Mutat Res. 2003 Feb-Mar;523-524:193-200. doi: 10.1016/s0027-5107(02)00335-4. Mutat Res. 2003. PMID: 12628517 Review.
The chemopreventive effect of tea against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adduct formation and its mechanism were studied. ...Rats pre-treated with tea and given PhIP 20 …
The chemopreventive effect of tea against 2-amino-1-methyl-6-phenylimidazo[4,5-b …
Metabolism of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat and other rodents.
Alexander J, Fossum BH, Reistad R, Holme JA. Alexander J, et al. Princess Takamatsu Symp. 1995;23:113-22. Princess Takamatsu Symp. 1995. PMID: 8844802 Review.
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant compound of the amino-imidazoazaarens (AIA) group of muta-/carcinogens isolated from the crust of fried meat. ...The major prod …
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the m …
Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Gooderham NJ, Zhu H, Lauber S, Boyce A, Creton S. Gooderham NJ, et al. Mutat Res. 2002 Sep 30;506-507:91-9. doi: 10.1016/s0027-5107(02)00155-0. Mutat Res. 2002. PMID: 12351148 Review.
The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), formed when meat containing food is cooked, induces cancer of the colon, prostate and mammary gland of rats, tumours that ar …
The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine …
Metabolites of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) in human urine after consumption of charbroiled or fried beef.
Strickland PT, Qian Z, Friesen MD, Rothman N, Sinha R. Strickland PT, et al. Mutat Res. 2002 Sep 30;506-507:163-73. doi: 10.1016/s0027-5107(02)00163-x. Mutat Res. 2002. PMID: 12351156 Review.
The major metabolites of PhIP detected in human urine are N(2)-OH-PhIP-N(2)-glucuronide, PhIP-N(2)-glucuronide, N(2)-OH-PhIP-N(3)-glucuronide, and 4'-PhIP-sulphate. ...Following cessation of broiled meat consumption, urinary PhIP declined …
The major metabolites of PhIP detected in human urine are N(2)-OH-PhIP-N(2)-glucuronide, PhIP-N(2)-glucuronide, N(2)-OH …
Detection of heterocyclic amine (PhIP) by fluorescently labelled cucurbit[7]uril.
Sun L, Wang Z, Hou J, Fang G, Liu J, Wang S. Sun L, et al. Analyst. 2022 May 30;147(11):2477-2483. doi: 10.1039/d2an00495j. Analyst. 2022. PMID: 35535597
In this study, inspired by the "host-guest" interaction mechanism, a new technique for detecting 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) was developed, taking advantage of the molecular …
In this study, inspired by the "host-guest" interaction mechanism, a new technique for detecting 2-amino-1-methyl …
Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP.
Nakagama H, Nakanishi M, Ochiai M. Nakagama H, et al. Cancer Sci. 2005 Oct;96(10):627-36. doi: 10.1111/j.1349-7006.2005.00107.x. Cancer Sci. 2005. PMID: 16232193 Free PMC article. Review.
In rats, several models have been established using chemical carcinogens, including azoxymethane and 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP). The former is a representative colon carcinog …
In rats, several models have been established using chemical carcinogens, including azoxymethane and 2-amino-1-methy …
2,086 results