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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
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1993 3
1994 14
1995 23
1996 20
1997 29
1998 12
1999 22
2000 16
2001 19
2002 22
2003 24
2004 18
2005 11
2006 15
2007 14
2008 23
2009 20
2010 16
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2012 30
2013 34
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764 results

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Page 1
Paroxysmal nocturnal hemoglobinuria.
Brodsky RA. Brodsky RA. Blood. 2014 Oct 30;124(18):2804-11. doi: 10.1182/blood-2014-02-522128. Epub 2014 Sep 18. Blood. 2014. PMID: 25237200 Free PMC article. Review.
GPI anchor protein deficiency is almost always due to somatic mutations in phosphatidylinositol glycan class A (PIGA), a gene involved in the first step of GPI anchor biosynthesis; however, alternative mutations that cause PNH have recently been discovered. In addit …
GPI anchor protein deficiency is almost always due to somatic mutations in phosphatidylinositol glycan class A (PIGA), a gene
Paroxysmal nocturnal haemoglobinuria.
Hill A, DeZern AE, Kinoshita T, Brodsky RA. Hill A, et al. Nat Rev Dis Primers. 2017 May 18;3:17028. doi: 10.1038/nrdp.2017.28. Nat Rev Dis Primers. 2017. PMID: 28516949 Free PMC article. Review.
The gene product of PIGA is required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; thus, PIGA mutations lead to a deficiency of GPI-anchored proteins, such as complement decay-accelerating factor (also known as CD55) and CD59 glycoprotei …
The gene product of PIGA is required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; thus, PIGA mut …
Paroxysmal Nocturnal Hemoglobinuria: Biology and Treatment.
Bravo-Perez C, Guarnera L, Williams ND, Visconte V. Bravo-Perez C, et al. Medicina (Kaunas). 2023 Sep 6;59(9):1612. doi: 10.3390/medicina59091612. Medicina (Kaunas). 2023. PMID: 37763731 Free PMC article. Review.
Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal hematopoietic disorder characterized by the lack of glycosylphosphatidylinositol-anchored proteins (GPI-APs) as a consequence of somatic mutations in the phosphatidylinositol glycan anchor biosynthesis class A ( …
Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal hematopoietic disorder characterized by the lack of glycosylphosphatidyli …
Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria.
Colden MA, Kumar S, Munkhbileg B, Babushok DV. Colden MA, et al. Front Immunol. 2022 Jan 28;12:830172. doi: 10.3389/fimmu.2021.830172. eCollection 2021. Front Immunol. 2022. PMID: 35154088 Free PMC article. Review.
PNH patients develop somatic loss-of-function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene (PIGA), required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. ...The loss of two GPI-anchored surface proteins, CD55 …
PNH patients develop somatic loss-of-function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene (PI
Gut microbiota alternation under the intestinal epithelium-specific knockout of mouse Piga gene.
Jangid A, Fukuda S, Seki M, Suzuki Y, Taylor TD, Ohno H, Prakash T. Jangid A, et al. Sci Rep. 2022 Jun 25;12(1):10812. doi: 10.1038/s41598-022-15150-5. Sci Rep. 2022. PMID: 35752737 Free PMC article.
Properly polarised epithelial cells are essential for the establishment of the barrier function of gut epithelia. The Piga gene is one among seven genes that encode for an enzyme which is involved in the first step of GPI-anchor biosynthesis. This is the firs …
Properly polarised epithelial cells are essential for the establishment of the barrier function of gut epithelia. The Piga gene
Simple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene.
Karnan S, Konishi Y, Ota A, Takahashi M, Damdindorj L, Hosokawa Y, Konishi H. Karnan S, et al. PLoS One. 2012;7(10):e47389. doi: 10.1371/journal.pone.0047389. Epub 2012 Oct 8. PLoS One. 2012. PMID: 23056640 Free PMC article.
Using this PIGA-based reporter system, we successfully detected adeno-associated virus (AAV)-mediated gene targeting events both with and without promoter-trap enrichment of gene-targeted cell population. ...Thus, our PIGA-based system is useful for mo …
Using this PIGA-based reporter system, we successfully detected adeno-associated virus (AAV)-mediated gene targeting events bo …
Drosophila models of PIGA-CDG mirror patient phenotypes.
Thorpe HJ, Owings KG, Aziz MC, Haller M, Coelho E, Chow CY. Thorpe HJ, et al. bioRxiv [Preprint]. 2023 Oct 27:2023.10.27.564441. doi: 10.1101/2023.10.27.564441. bioRxiv. 2023. PMID: 37961693 Free PMC article. Updated. Preprint.
Mutations in the phosphatidylinositol glycan biosynthesis class A (PIGA) gene cause a rare, X-linked recessive congenital disorder of glycosylation (CDG). ...The PIGA gene encodes an enzyme involved in the first step of GPI anchor biosynthesis. ...
Mutations in the phosphatidylinositol glycan biosynthesis class A (PIGA) gene cause a rare, X-linked recessive congenital diso …
Pig-a gene mutation database.
Shemansky JM, McDaniel LP, Klimas C, Dertinger SD, Dobrovolsky VN, Kimoto T, Horibata K, Polli JE, Heflich RH. Shemansky JM, et al. Environ Mol Mutagen. 2019 Oct;60(8):759-762. doi: 10.1002/em.22298. Epub 2019 Jun 7. Environ Mol Mutagen. 2019. PMID: 31090953
Mutations in the X-linked phosphatidylinositol glycan, class A gene (Pig-a) lead to loss of glycosylphosphatidylinositol (GPI) anchors and GPI-anchored proteins from the surface of erythrocytes and other mammalian cells. The Pig-a gene mutation assay quantifies in v …
Mutations in the X-linked phosphatidylinositol glycan, class A gene (Pig-a) lead to loss of glycosylphosphatidylinositol (GPI) anchor …
The correlation between multiple congenital anomalies hypotonia seizures syndrome 2 and PIGA: a case of novel PIGA germline variant and literature review.
Liu X, Meng J, Ma J, Shu J, Gu C, Chen X, Li D, Cai C. Liu X, et al. Mol Biol Rep. 2022 Nov;49(11):10469-10477. doi: 10.1007/s11033-022-07614-8. Epub 2022 Sep 18. Mol Biol Rep. 2022. PMID: 36116096 Review.
BACKGROUND: PIGA (PIG class A) gene codes for the PIG-A protein, which is a catalytic subunit of GPI-GlcNAc transferase. GPI-anchored proteins play an important role in the metabolism of mammals. Somatic variants of PIGA genes in bone marrow hematopoie …
BACKGROUND: PIGA (PIG class A) gene codes for the PIG-A protein, which is a catalytic subunit of GPI-GlcNAc transferase. GPI-a …
Integrated Analysis of Transcriptome Changes in Osteoarthritis: Gene Expression, Pathways and Alternative Splicing.
Li C, Wei P, Wang L, Wang Q, Wang H, Zhang Y. Li C, et al. Cartilage. 2023 Jun;14(2):235-246. doi: 10.1177/19476035231154511. Epub 2023 Feb 17. Cartilage. 2023. PMID: 36799242 Free PMC article.
DESIGN: By analyzing RNA-seq data, we found the molecular changes at the transcriptome level such as alternative splicing, gene expression, and molecular pathways in OA knees cartilage. RESULTS: Expression analysis have identified 457 differential expressed genes in …
DESIGN: By analyzing RNA-seq data, we found the molecular changes at the transcriptome level such as alternative splicing, gene expre …
764 results