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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 7
1984 15
1985 16
1986 23
1987 33
1988 30
1989 52
1990 48
1991 45
1992 42
1993 35
1994 56
1995 35
1996 40
1997 35
1998 32
1999 39
2000 50
2001 34
2002 45
2003 39
2004 61
2005 40
2006 48
2007 64
2008 66
2009 58
2010 56
2011 46
2012 66
2013 48
2014 69
2015 68
2016 57
2017 55
2018 47
2019 39
2020 52
2021 56
2022 42
2023 34
2024 13

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1,657 results

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Page 1
MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial.
Brown RB, Tozer DJ, Loubière L, Harshfield EL, Hong YT, Fryer TD, Williams GB, Graves MJ, Aigbirhio FI, O'Brien JT, Markus HS. Brown RB, et al. Alzheimers Dement. 2024 Apr 17. doi: 10.1002/alz.13830. Online ahead of print. Alzheimers Dement. 2024. PMID: 38629936
Co-primary outcomes were microglial signal (determined using (11)C-PK11195 positron emission tomography) and BBB permeability (using dynamic contrast-enhanced MRI). ...Serum inflammatory markers were not affected. DISCUSSION: (11)C-PK11195 binding and increased BBB …
Co-primary outcomes were microglial signal (determined using (11)C-PK11195 positron emission tomography) and BBB permeability (using …
Are central and systemic inflammation associated with fatigue in cerebral small vessel disease?
Jolly AA, Brown RB, Tozer DJ, Hong YT, Fryer TD, Aigbirhio FI, O'Brien JT, Markus HS. Jolly AA, et al. Int J Stroke. 2024 Apr 12:17474930241245613. doi: 10.1177/17474930241245613. Online ahead of print. Int J Stroke. 2024. PMID: 38533609 Free article.
Microglial signal was taken as a proxy for neuroinflammation, assessed with radioligand (11)C-PK11195. Of these, 30 subjects had full PET datasets for analysis. We assessed global (11)C-PK11195 binding and hotspots of (11)C-PK11195 binding in the normal-appea …
Microglial signal was taken as a proxy for neuroinflammation, assessed with radioligand (11)C-PK11195. Of these, 30 subjects had full …
Microglial Activation and Progression of Nigrostriatal Dysfunction in Isolated REM Sleep Behavior Disorder.
Staer K, Iranzo A, Stokholm MG, Hvingelby VS, Danielsen EH, Østergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Santamaria J, Møller A, Gaig C, Brooks DJ, Borghammer P, Tolosa E, Pavese N. Staer K, et al. Mov Disord. 2024 Mar 13. doi: 10.1002/mds.29767. Online ahead of print. Mov Disord. 2024. PMID: 38477376
BACKGROUND: Using (11) C-(R)-PK11195-PET, we found increased microglia activation in isolated REM sleep behavior disorder (iRBD) patients. ...CONCLUSIONS: Subjects with increased baseline (11) C-(R)-PK11195 binding have greater changes in nigrostriatal function, sug …
BACKGROUND: Using (11) C-(R)-PK11195-PET, we found increased microglia activation in isolated REM sleep behavior disorder (iRBD) pati …
Sex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals.
Laaksonen S, Saraste M, Nylund M, Hinz R, Snellman A, Rinne J, Matilainen M, Airas L. Laaksonen S, et al. Front Neurol. 2024 Feb 20;15:1352116. doi: 10.3389/fneur.2024.1352116. eCollection 2024. Front Neurol. 2024. PMID: 38445263 Free PMC article.
TSPO-expressing microglia were measured using the TSPO-binding radioligand [(11)C](R)-PK11195 and brain positron emission tomography (PET). TSPO-binding was quantified as distribution volume ratio (DVR) in normal-appearing white matter (NAWM), thalamus, whole brain and cor …
TSPO-expressing microglia were measured using the TSPO-binding radioligand [(11)C](R)-PK11195 and brain positron emission tomography …
Pulmonary inflammation decreases with ultra-protective ventilation in experimental ARDS under VV-ECMO: a positron emission tomography study.
Deniel G, Dhelft F, Lancelot S, Orkisz M, Roux E, Mouton W, Benzerdjeb N, Richard JC, Bitker L. Deniel G, et al. Front Med (Lausanne). 2024 Feb 20;11:1338602. doi: 10.3389/fmed.2024.1338602. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38444415 Free PMC article.
Pharmacokinetic multicompartment models were used to quantify regional [(11)C](R)-PK11195 lung uptake. [(11)C](R)-PK11195 lung uptake and CT-derived respiratory variables were studied regionally across eight lung regions distributed along the antero-posterior axis. …
Pharmacokinetic multicompartment models were used to quantify regional [(11)C](R)-PK11195 lung uptake. [(11)C](R)-PK11195 lung …
PET Imaging to Measure Neuroinflammation In Vivo.
Malpetti M, Franzmeier N, Brendel M. Malpetti M, et al. Methods Mol Biol. 2024;2785:177-193. doi: 10.1007/978-1-0716-3774-6_12. Methods Mol Biol. 2024. PMID: 38427195
We discuss the development and application of several PET radioligands, including first-generation ligands like PK11195 and Ro5-4864, as well as second- and third-generation ligands such as [11C]PBR28, [18F]DPA-714, [18F]GE-180, and [11C]ER176. ...
We discuss the development and application of several PET radioligands, including first-generation ligands like PK11195 and Ro5-4864, …
Cognitive dysfunction in early experimental metabolic dysfunction-associated steatotic liver disease is associated with systemic inflammation and neuroinflammation.
Kjærgaard K, Daugaard Mikkelsen AC, Landau AM, Eriksen PL, Hamilton-Dutoit S, Magnusson NE, Thomsen MB, Chen F, Vilstrup H, Mookerjee RP, Bay-Richter C, Thomsen KL. Kjærgaard K, et al. JHEP Rep. 2023 Dec 21;6(3):100992. doi: 10.1016/j.jhepr.2023.100992. eCollection 2024 Mar. JHEP Rep. 2023. PMID: 38415019 Free PMC article.
In the prefrontal brain cortex, we observed a 19% increase in microglial activation confirmed by Iba1 immunohistochemistry (p = 0.03) and (3)H-PK11195 autoradiography (p <0.01). In parallel, synaptic density was reduced to 92%, assessed by (3)H-UCB-J autoradiography (p …
In the prefrontal brain cortex, we observed a 19% increase in microglial activation confirmed by Iba1 immunohistochemistry (p = 0.03) and (3 …
Evaluation of Non-Invasive Methods for (R)-[(11)C]PK11195 PET Image Quantification in Multiple Sclerosis.
Mantovani DBA, Pitombeira MS, Schuck PN, de Araújo AS, Buchpiguel CA, de Paula Faria D, M da Silva AM. Mantovani DBA, et al. J Imaging. 2024 Jan 31;10(2):39. doi: 10.3390/jimaging10020039. J Imaging. 2024. PMID: 38392087 Free PMC article.
This study aims to evaluate non-invasive PET quantification methods for (R)-[(11)C]PK11195 uptake measurement in multiple sclerosis (MS) patients and healthy controls (HC) in comparison with arterial input function (AIF) using dynamic (R)-[(11)C]PK11195 PET and magn …
This study aims to evaluate non-invasive PET quantification methods for (R)-[(11)C]PK11195 uptake measurement in multiple sclerosis ( …
Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury.
Song J, Yu W, Chen S, Huang J, Zhou C, Liang H. Song J, et al. Eur J Pharmacol. 2024 Mar 5;966:176342. doi: 10.1016/j.ejphar.2024.176342. Epub 2024 Jan 28. Eur J Pharmacol. 2024. PMID: 38290569
Finally, remimazolam treatment impaired the activation of bone marrow-derived fibroblasts and blunted the transformation of macrophages to myofibroblasts in FA nephropathy. Additionally, the benzodiazepine receptor antagonist PK-11195 partially reversed the protecti …
Finally, remimazolam treatment impaired the activation of bone marrow-derived fibroblasts and blunted the transformation of macrophages to m …
1,657 results