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Headache disorders in patients with Ehlers-Danlos syndromes and hypermobility spectrum disorders.
Mehta D, Simmonds L, Hakim AJ, Matharu M. Mehta D, et al. Front Neurol. 2024 Nov 8;15:1460352. doi: 10.3389/fneur.2024.1460352. eCollection 2024. Front Neurol. 2024. PMID: 39582682 Free PMC article. Review.
Orthostatic headache is an important presentation, and should raise suspicion of an underlying spinal cerebrospinal fluid leak, dysautonomia, and craniocervical pathology, which are all associated with heritable connective tissue disorders (HCTD) including EDS. ...This is …
Orthostatic headache is an important presentation, and should raise suspicion of an underlying spinal cerebrospinal fluid leak, dysautonomia …
Hyperventilation during rest and exercise in orthostatic intolerance and Spiky-Leaky Syndrome.
Hashemizad A, Dela Cruz J, Narayan A, Maxwell AJ. Hashemizad A, et al. Front Neurol. 2025 Apr 17;16:1512671. doi: 10.3389/fneur.2025.1512671. eCollection 2025. Front Neurol. 2025. PMID: 40313612 Free PMC article.
This hyperventilation appears to be a key characteristic in a newly described subset of patients with OIDS who also exhibit craniocervical instability, mast cell activation syndrome (MCAS), hypermobility spectrum disorder (HSD), and the phenomenon of alternating int …
This hyperventilation appears to be a key characteristic in a newly described subset of patients with OIDS who also exhibit craniocervica …
Postural orthostatic tachycardia syndrome: when dysautonomia misleads: a mechanistic argument for compensatory orthostatic tachycardia.
Chopra P. Chopra P. Front Neurol. 2026 Apr 10;17:1806502. doi: 10.3389/fneur.2026.1806502. eCollection 2026. Front Neurol. 2026. PMID: 42037722 Free PMC article. Review.
Postural orthostatic tachycardia syndrome (POTS) is defined by chronic orthostatic intolerance accompanied by an excessive increment in sinus heart rate on standing in the absence of significant orthostatic hypotension. ...This reframing does not minimize the severity of …
Postural orthostatic tachycardia syndrome (POTS) is defined by chronic orthostatic intolerance accompanied by an excessive increment …
Characterizing a new clinical phenotype: the co-existence of cerebral venous outflow and connective tissue disorders.
Midtlien JP, Curry BP, Chang E, Kiritsis NR, Aldridge JB, Fargen KM. Midtlien JP, et al. Front Neurol. 2024 Jan 10;14:1305972. doi: 10.3389/fneur.2023.1305972. eCollection 2023. Front Neurol. 2024. PMID: 38269002 Free PMC article.
Aside from CVD and IIH, the most common associated conditions were postural orthostatic tachycardia syndrome (POTS; 55.8%), cerebrospinal fluid (CSF) leaks (51.2%), dysautonomia (45.3%), cranio-cervical instability (37.2%), mast cell activation syndrome (25.6%), and …
Aside from CVD and IIH, the most common associated conditions were postural orthostatic tachycardia syndrome (POTS; 55.8%), cerebrosp …