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Page 1
Diagnosis of mast cell activation syndrome: a global "consensus-2".
Afrin LB, Ackerley MB, Bluestein LS, Brewer JH, Brook JB, Buchanan AD, Cuni JR, Davey WP, Dempsey TT, Dorff SR, Dubravec MS, Guggenheim AG, Hindman KJ, Hoffman B, Kaufman DL, Kratzer SJ, Lee TM, Marantz MS, Maxwell AJ, McCann KK, McKee DL, Menk Otto L, Pace LA, Perkins DD, Radovsky L, Raleigh MS, Rapaport SA, Reinhold EJ, Renneker ML, Robinson WA, Roland AM, Rosenbloom ES, Rowe PC, Ruhoy IS, Saperstein DS, Schlosser DA, Schofield JR, Settle JE, Weinstock LB, Wengenroth M, Westaway M, Xi SC, Molderings GJ. Afrin LB, et al. Diagnosis (Berl). 2020 Apr 22;8(2):137-152. doi: 10.1515/dx-2020-0005. Print 2021 May 26. Diagnosis (Berl). 2020. PMID: 32324159 Review.
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" (MC …
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross …
Postural Orthostatic Tachycardia Syndrome (POTS): A critical assessment.
Olshansky B, Cannom D, Fedorowski A, Stewart J, Gibbons C, Sutton R, Shen WK, Muldowney J, Chung TH, Feigofsky S, Nayak H, Calkins H, Benditt DG. Olshansky B, et al. Prog Cardiovasc Dis. 2020 May-Jun;63(3):263-270. doi: 10.1016/j.pcad.2020.03.010. Epub 2020 Mar 25. Prog Cardiovasc Dis. 2020. PMID: 32222376 Free PMC article. Review.
Although diagnostic criteria have been developed characterizing postural orthostatic tachycardia syndrome (POTS), no single set of criteria is universally accepted. ...Here we address critical issues regarding the pathophysiology and diagnosis o …
Although diagnostic criteria have been developed characterizing postural orthostatic tachycardia syndrome (POTS), no si …
Postural Orthostatic Tachycardia Syndrome: A State-of-the-Art Review.
Lau DH, Fedorowski A, Raj SR, Schild C, Pace LA, Blitshteyn S, Raj V, Boris JR, Kavi L, Seeley MC, Gallagher C. Lau DH, et al. Heart Lung Circ. 2026 Feb;35(2):171-185. doi: 10.1016/j.hlc.2025.09.004. Epub 2026 Jan 9. Heart Lung Circ. 2026. PMID: 41519610 Free article. Review.
Although the diagnostic criteria require an orthostatic challenge test, the associated symptom burden can be broad and is often missed by treating healthcare professionals, resulting in significant diagnostic delay. ...There is an urgent need to provide servi …
Although the diagnostic criteria require an orthostatic challenge test, the associated symptom burden can be broad and is ofte …
Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J. Rocha EA, et al. Arq Bras Cardiol. 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. Arq Bras Cardiol. 2021. PMID: 33886735 Free PMC article. English, Portuguese.
Chronic Fatigue Syndrome represents a form of Dysautonomia and has been renamed as a systemic disease of exercise intolerance, with new diagnostic criteria: 1 - Unexplained fatigue, leading to occupational disability for more than 6 months; 2 - Feeling ill after exe …
Chronic Fatigue Syndrome represents a form of Dysautonomia and has been renamed as a systemic disease of exercise intolerance, with new d …
Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities.
Blitshteyn S. Blitshteyn S. Curr Neurol Neurosci Rep. 2023 Nov;23(11):769-776. doi: 10.1007/s11910-023-01307-w. Epub 2023 Oct 17. Curr Neurol Neurosci Rep. 2023. PMID: 37847487 Review.
Diagnostic criteria, pathophysiologic mechanisms, and therapeutic considerations in patients with migraine and comorbid dysautonomia, HSD, and MCAS are reviewed. ...In clinical setting, dysautonomia, HSD, and MCAS may present a diagnostic and therapeutic chal …
Diagnostic criteria, pathophysiologic mechanisms, and therapeutic considerations in patients with migraine and comorbid dysaut …
The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS).
Kucharik AH, Chang C. Kucharik AH, et al. Clin Rev Allergy Immunol. 2020 Jun;58(3):273-297. doi: 10.1007/s12016-019-08755-8. Clin Rev Allergy Immunol. 2020. PMID: 31267471 Review.
MCAS is a poorly defined clinical entity, and many studies do not adhere to the proposed criteria when establishing the diagnosis. Patients previously diagnosed with EDS hypermobility type may not meet the new, stricter criteria for hEDS but may for a less se …
MCAS is a poorly defined clinical entity, and many studies do not adhere to the proposed criteria when establishing the diagnosis …
Long COVID in pediatrics-epidemiology, diagnosis, and management.
Toepfner N, Brinkmann F, Augustin S, Stojanov S, Behrends U. Toepfner N, et al. Eur J Pediatr. 2024 Apr;183(4):1543-1553. doi: 10.1007/s00431-023-05360-y. Epub 2024 Jan 27. Eur J Pediatr. 2024. PMID: 38279014 Free PMC article. Review.
Some patients present with postural tachycardia syndrome (PoTS), and a small number of cases fulfill the clinical criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). To date, no diagnostic marker has been established, and differential …
Some patients present with postural tachycardia syndrome (PoTS), and a small number of cases fulfill the clinical criteria of …
AGA Clinical Practice Update on GI Manifestations and Autonomic or Immune Dysfunction in Hypermobile Ehlers-Danlos Syndrome: Expert Review.
Aziz Q, Harris LA, Goodman BP, Simrén M, Shin A. Aziz Q, et al. Clin Gastroenterol Hepatol. 2025 Jul;23(8):1291-1302. doi: 10.1016/j.cgh.2025.02.015. Epub 2025 May 19. Clin Gastroenterol Hepatol. 2025. PMID: 40387691 Review.
BEST PRACTICE ADVICE 2: Testing for POTS/MCAS should be targeted to patients presenting with clinical manifestations of POTS/MCAS, but universal testing for POTS/MCAS in all patients with hEDS/HSDs is not supported by the current evidence. ...BEST PRACTICE AD …
BEST PRACTICE ADVICE 2: Testing for POTS/MCAS should be targeted to patients presenting with clinical manifestations of POTS/M …
Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance.
Raj SR, Guzman JC, Harvey P, Richer L, Schondorf R, Seifer C, Thibodeau-Jarry N, Sheldon RS. Raj SR, et al. Can J Cardiol. 2020 Mar;36(3):357-372. doi: 10.1016/j.cjca.2019.12.024. Can J Cardiol. 2020. PMID: 32145864
Conventional POTS criteria require an excessive orthostatic tachycardia in the absence of substantial orthostatic hypotension, and predominant symptoms of orthostatic intolerance, worse with upright posture and better with recumbence. ...One identified problem was t …
Conventional POTS criteria require an excessive orthostatic tachycardia in the absence of substantial orthostatic hypotension, …
The Suggested Relationships Between Common GI Symptoms and Joint Hypermobility, POTS, and MCAS.
Quigley EMM, Noble O, Ansari U. Quigley EMM, et al. Gastroenterol Hepatol (N Y). 2024 Aug;20(8):479-489. Gastroenterol Hepatol (N Y). 2024. PMID: 39205953 Free PMC article.
This cluster is composed of diagnoses of hypermobility spectrum disorders (HSDs) such as joint hypermobility and hypermobile variant Ehlers-Danlos syndrome (hEDS), postural orthostatic tachycardia syndrome (POTS), and mast cell activation syndrome (MCAS). The diagnosis …
This cluster is composed of diagnoses of hypermobility spectrum disorders (HSDs) such as joint hypermobility and hypermobile variant Ehlers- …
150 results