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71 results

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Page 1
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Mar PL, Raj SR. Mar PL, et al. Annu Rev Med. 2020 Jan 27;71:235-248. doi: 10.1146/annurev-med-041818-011630. Epub 2019 Aug 14. Annu Rev Med. 2020. PMID: 31412221 Review.
The approach to the treatment of POTS centers on treating the underlying pathophysiologic mechanism. Stockings, abdominal binders, and vasoconstrictors are used to enhance venous return in partial neuropathic POTS. Exercise and volume expansion are the main treatmen …
The approach to the treatment of POTS centers on treating the underlying pathophysiologic mechanism. Stockings, abdominal binders, an …
Pathophysiology and management of postural orthostatic tachycardia syndrome (POTS): A literature review.
Ghazal M, Akkawi AR, Fancher A, Oundo E, Tanzeem H, Sajjad L, Briasoulis A. Ghazal M, et al. Curr Probl Cardiol. 2025 Mar;50(3):102977. doi: 10.1016/j.cpcardiol.2024.102977. Epub 2024 Dec 18. Curr Probl Cardiol. 2025. PMID: 39706392 Review.
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tailored management strategies. ...In hyperadrenergic POTS, excessive norepinephrine production or impaired reuptake leads to symp …
Recent studies have identified three primary POTS phenotypes-hyperadrenergic, neuropathic, and hypovolemic-each requiring tail …
Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome.
Taub PR, Zadourian A, Lo HC, Ormiston CK, Golshan S, Hsu JC. Taub PR, et al. J Am Coll Cardiol. 2021 Feb 23;77(7):861-871. doi: 10.1016/j.jacc.2020.12.029. J Am Coll Cardiol. 2021. PMID: 33602468 Free article. Clinical Trial.
OBJECTIVES: This study investigated the effect of ivabradine (selective blocker of the I(funny) channel in the sinoatrial node) on heart rate, quality of life (QOL), and plasma norepinephrine (NE) levels in patients with hyperadrenergic POTS defined by plasma NE &gt …
OBJECTIVES: This study investigated the effect of ivabradine (selective blocker of the I(funny) channel in the sinoatrial node) on heart rat …
Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine.
Okamoto LE, Urechie V, Rigo S, Abner JJ, Giesecke M, Muldowney JAS, Furlan R, Shibao CA, Shirey-Rice JK, Pulley JM, Diedrich A, Biaggioni I. Okamoto LE, et al. Hypertension. 2024 Nov;81(11):2237-2247. doi: 10.1161/HYPERTENSIONAHA.124.23035. Epub 2024 Aug 7. Hypertension. 2024. PMID: 39109428 Free PMC article.
BACKGROUND: A subset of patients with postural tachycardia syndrome (POTS) are thought to have a primary hyperadrenergic cause. We assessed clinical biomarkers to identify those that would benefit from sympatholytic therapy. METHODS: We measured sympathetic function …
BACKGROUND: A subset of patients with postural tachycardia syndrome (POTS) are thought to have a primary hyperadrenergic cause …
Postural tachycardia syndrome (POTS).
Low PA, Sandroni P, Joyner M, Shen WK. Low PA, et al. J Cardiovasc Electrophysiol. 2009 Mar;20(3):352-8. doi: 10.1111/j.1540-8167.2008.01407.x. Epub 2009 Jan 16. J Cardiovasc Electrophysiol. 2009. PMID: 19207771 Free PMC article. Review.
Prolonged deconditioning may also interact with these mechanisms to exacerbate symptoms. The evaluation of POTS requires a focused history and examination, followed by tests that should include HUT, some estimation of volume status and preferably some evaluation of periphe …
Prolonged deconditioning may also interact with these mechanisms to exacerbate symptoms. The evaluation of POTS requires a focused hi …
Complete remission with histamine blocker in a patient with intractable hyperadrenergic postural orthostatic tachycardia syndrome secondary to long coronavirus disease syndrome.
González-Alvarez F, Estañol B, González-Hermosillo JA, Gómez-Pérez FJ, Tamez-Torres KM, Peña E, Cantú C, Chiquete E, Sifuentes-Osornio J, Alba-Lorenzo MDC, Celestino-Montelongo DA, Salazar-Calderón GE, Aceves Buendia JJ. González-Alvarez F, et al. J Hypertens. 2024 May 1;42(5):928-932. doi: 10.1097/HJH.0000000000003669. Epub 2024 Mar 8. J Hypertens. 2024. PMID: 38526146 Free PMC article.
A subtype of POTS, hyperadrenergic POTS, has been widely studied because of its association with mast cell activation syndrome (MCAS). Although a causative relationship between PCC, hyperadrenergic POTS, and MCAS remains unrevealed, these syndro …
A subtype of POTS, hyperadrenergic POTS, has been widely studied because of its association with mast cell activation s …
Evaluation of postural tachycardia syndrome (POTS).
Goodman BP. Goodman BP. Auton Neurosci. 2018 Dec;215:12-19. doi: 10.1016/j.autneu.2018.04.004. Epub 2018 Apr 22. Auton Neurosci. 2018. PMID: 29705015 Review.
The diagnostic evaluation of a patient with suspected postural tachycardia syndrome (POTS) requires a thoughtful diagnostic approach utilizing a careful clinical history and examination, laboratory, and autonomic testing. ...The purpose of autonomic testing is to confirm a …
The diagnostic evaluation of a patient with suspected postural tachycardia syndrome (POTS) requires a thoughtful diagnostic approach …
Clinical features of hyperadrenergic postural tachycardia syndrome in children.
Zhang Q, Chen X, Li J, Du J. Zhang Q, et al. Pediatr Int. 2014 Dec;56(6):813-816. doi: 10.1111/ped.12392. Epub 2014 Oct 15. Pediatr Int. 2014. PMID: 24862636
BACKGROUND: Hyperadrenergic postural tachycardia syndrome (POTS) is the main phenotype of POTS. The aim of this study was to present our single-center experience of hyperadrenergic POTS in children and adolescents. ...CONCLUSION: Patients with …
BACKGROUND: Hyperadrenergic postural tachycardia syndrome (POTS) is the main phenotype of POTS. The aim of this study w …
Long-Term Outcomes of Hyperadrenergic Orthostatic Hypotension.
Castro RA, Vernetti PM, Biaggioni I, Raj SR, Kaufmann H, Shibao CA. Castro RA, et al. Res Sq [Preprint]. 2023 Sep 11:rs.3.rs-3318273. doi: 10.21203/rs.3.rs-3318273/v1. Res Sq. 2023. Update in: Clin Auton Res. 2026 May 15. doi: 10.1007/s10286-026-01211-6. PMID: 37790494 Free PMC article. Updated. Preprint.
PURPOSE: Hyperadrenergic orthostatic hypotension is a subtype of orthostatic hypotension associated with elevated norepinephrine levels upon standing. ...Patients with hyperadrenergic orthostatic hypotension require careful monitoring, given that this condition may …
PURPOSE: Hyperadrenergic orthostatic hypotension is a subtype of orthostatic hypotension associated with elevated norepinephrine leve …
Carbidopa: beyond Parkinson's disease.
Lenka A, Vernino S. Lenka A, et al. Clin Auton Res. 2025 Jun;35(3):347-352. doi: 10.1007/s10286-025-01122-y. Epub 2025 Mar 8. Clin Auton Res. 2025. PMID: 40056295 Review.
Our literature search revealed the use of carbidopa in three primary autonomic diseases to treat either nausea or symptoms of sympathetic hyperactivity: (1) familial dysautonomia, (2) hyperadrenergic postural orthostatic tachycardia syndrome (POTS), and (3) afferent …
Our literature search revealed the use of carbidopa in three primary autonomic diseases to treat either nausea or symptoms of sympathetic hy …
71 results