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Page 1
Diagnosis of mast cell activation syndrome: a global "consensus-2".
Afrin LB, Ackerley MB, Bluestein LS, Brewer JH, Brook JB, Buchanan AD, Cuni JR, Davey WP, Dempsey TT, Dorff SR, Dubravec MS, Guggenheim AG, Hindman KJ, Hoffman B, Kaufman DL, Kratzer SJ, Lee TM, Marantz MS, Maxwell AJ, McCann KK, McKee DL, Menk Otto L, Pace LA, Perkins DD, Radovsky L, Raleigh MS, Rapaport SA, Reinhold EJ, Renneker ML, Robinson WA, Roland AM, Rosenbloom ES, Rowe PC, Ruhoy IS, Saperstein DS, Schlosser DA, Schofield JR, Settle JE, Weinstock LB, Wengenroth M, Westaway M, Xi SC, Molderings GJ. Afrin LB, et al. Diagnosis (Berl). 2020 Apr 22;8(2):137-152. doi: 10.1515/dx-2020-0005. Print 2021 May 26. Diagnosis (Berl). 2020. PMID: 32324159 Review.
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast …
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs …
The Relationship Between Hypermobile Ehlers-Danlos Syndrome (hEDS), Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS).
Kucharik AH, Chang C. Kucharik AH, et al. Clin Rev Allergy Immunol. 2020 Jun;58(3):273-297. doi: 10.1007/s12016-019-08755-8. Clin Rev Allergy Immunol. 2020. PMID: 31267471 Review.
In recent years, an association between hypermobile Ehlers-Danlos syndrome (hEDS), mast cell activation syndrome (MCAS), and postural orthostatic tachycardia syndrome (POTS) has garnered attention and patients are increasingly presenting with this tria …
In recent years, an association between hypermobile Ehlers-Danlos syndrome (hEDS), mast cell activation syndrome (MCAS) …
Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities.
Blitshteyn S. Blitshteyn S. Curr Neurol Neurosci Rep. 2023 Nov;23(11):769-776. doi: 10.1007/s11910-023-01307-w. Epub 2023 Oct 17. Curr Neurol Neurosci Rep. 2023. PMID: 37847487 Review.
The most common autonomic disorders are postural orthostatic tachycardia syndrome (POTS), neurocardiogenic syncope (NCS), and orthostatic hypotension (OH), which may be encountered in clinical practice as part of a triad of dysautonomia, hypermobility spectrum disorders (H …
The most common autonomic disorders are postural orthostatic tachycardia syndrome (POTS), neurocardiogenic syncope (NCS), and orthost …
The relationship between mast cell activation syndrome, postural tachycardia syndrome, and Ehlers-Danlos syndrome.
Wang E, Ganti T, Vaou E, Hohler A. Wang E, et al. Allergy Asthma Proc. 2021 May 1;42(3):243-246. doi: 10.2500/aap.2021.42.210022. Allergy Asthma Proc. 2021. PMID: 33980338
Background: Postural tachycardia syndrome (POTS), hypermobile Ehlers-Danlos syndrome (EDS), and mast cell activation syndrome (MCAS) can occur in the same patient. ...The demographics of the patients and diagnoses of POTS, EDS, or MCAS were reco …
Background: Postural tachycardia syndrome (POTS), hypermobile Ehlers-Danlos syndrome (EDS), and mast cell activation …
Neuropsychiatric Manifestations of Mast Cell Activation Syndrome and Response to Mast-Cell-Directed Treatment: A Case Series.
Weinstock LB, Nelson RM, Blitshteyn S. Weinstock LB, et al. J Pers Med. 2023 Oct 31;13(11):1562. doi: 10.3390/jpm13111562. J Pers Med. 2023. PMID: 38003876 Free PMC article.
Mast cell activation syndrome (MCAS) is an immune disease with an estimated prevalence of 17%. Mast cell chemical mediators lead to heterogeneous multisystemic inflammatory and allergic manifestations. ...
Mast cell activation syndrome (MCAS) is an immune disease with an estimated prevalence of 17%. Mast cell …
Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association.
Kohno R, Cannom DS, Olshansky B, Xi SC, Krishnappa D, Adkisson WO, Norby FL, Fedorowski A, Benditt DG. Kohno R, et al. J Am Heart Assoc. 2021 Sep 7;10(17):e021002. doi: 10.1161/JAHA.121.021002. Epub 2021 Aug 16. J Am Heart Assoc. 2021. PMID: 34398691 Free PMC article.
Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findi …
Background Recently there has been increased interest in a possible association between mast cell activation (MCA) diso …
The Clinical Relevance of Mast Cell Activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Rohrhofer J, Ebner L, Schweighardt J, Stingl M, Untersmayr E. Rohrhofer J, et al. Diagnostics (Basel). 2025 Nov 7;15(22):2828. doi: 10.3390/diagnostics15222828. Diagnostics (Basel). 2025. PMID: 41300853 Free PMC article.
Background/Objectives: Growing evidence suggests that mast cell activation (MCA) may contribute to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating disorder characterized by persistent fatigue and post-exertional malaise (PEM). ...R …
Background/Objectives: Growing evidence suggests that mast cell activation (MCA) may contribute to Myalgic Encephalomye …
Dysautonomia in the Ehlers-Danlos syndromes and hypermobility spectrum disorders-With a focus on the postural tachycardia syndrome.
Mathias CJ, Owens A, Iodice V, Hakim A. Mathias CJ, et al. Am J Med Genet C Semin Med Genet. 2021 Dec;187(4):510-519. doi: 10.1002/ajmg.c.31951. Epub 2021 Nov 12. Am J Med Genet C Semin Med Genet. 2021. PMID: 34766441 Review.
In some, the mast cell activation syndrome may be contributary, especially if it causes vasodilatation. This paper reviews neurocardiovascular dysautonomia with an emphasis on PoTS, its characteristics, associations, pathophysiology, investigation, and …
In some, the mast cell activation syndrome may be contributary, especially if it causes vasodilatation. This paper revi …
Prevalence of mast cell activation disorders and hereditary alpha tryptasemia among patients with postural orthostatic tachycardia syndrome and Ehlers-Danlos syndrome: A systematic review.
Farley M, Estrada-Mendizabal RJ, Gansert EA, Voelker D, Marks LA, Gonzalez-Estrada A. Farley M, et al. Ann Allergy Asthma Immunol. 2025 Jul;135(1):97-102. doi: 10.1016/j.anai.2025.03.022. Epub 2025 Apr 2. Ann Allergy Asthma Immunol. 2025. PMID: 40185471
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndrome (EDS) are often reported to occur concurrently with mast cell activation disorders (MCADs) and hereditary alpha tryptasemia (HAT). ...However, it must be mentioned …
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndrome (EDS) are often reported to occur concurrentl …
59 results