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pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysis.
Russo G, Claudio PP, Fu Y, Stiegler P, Yu Z, Macaluso M, Giordano A. Russo G, et al. Oncogene. 2003 Oct 9;22(44):6959-69. doi: 10.1038/sj.onc.1206866. Oncogene. 2003. PMID: 14534545
Previous data demonstrated an independent role for the reduction or loss of pRb2/p130 expression in the formation and/or progression of lung carcinoma. Rb2/p130 is mutated in a human cell line of lung small cell carcinoma as well as in primary lung tumors. To identify pote …
Previous data demonstrated an independent role for the reduction or loss of pRb2/p130 expression in the formation and/or progression …
Simian virus 40-like DNA sequences and large-T antigen-retinoblastoma family protein pRb2/p130 interaction in human mesothelioma.
Mutti L, De Luca A, Claudio PP, Convertino G, Carbone M, Giordano A. Mutti L, et al. Dev Biol Stand. 1998;94:47-53. Dev Biol Stand. 1998. PMID: 9776225
We have also demonstrated that the SV40 Tag detected in human mesothelioma binds the retinoblastoma family protein pRb2/p130 in 5/5 specimens studied. We submit that the tumorigenic potential of SV40 Tag in some human mesotheliomas may arise from its ability to interact wi …
We have also demonstrated that the SV40 Tag detected in human mesothelioma binds the retinoblastoma family protein pRb2/p130 in 5/5 s …
Differential expression of Rb2/p130 and p107 in normal human tissues and in primary lung cancer.
Baldi A, Esposito V, De Luca A, Fu Y, Meoli I, Giordano GG, Caputi M, Baldi F, Giordano A. Baldi A, et al. Clin Cancer Res. 1997 Oct;3(10):1691-7. Clin Cancer Res. 1997. PMID: 9815552
Two proteins, p107 and pRb2/p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "po …
Two proteins, p107 and pRb2/p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb), we …
Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer.
Claudio PP, Howard CM, Pacilio C, Cinti C, Romano G, Minimo C, Maraldi NM, Minna JD, Gelbert L, Leoncini L, Tosi GM, Hicheli P, Caputi M, Giordano GG, Giordano A. Claudio PP, et al. Cancer Res. 2000 Jan 15;60(2):372-82. Cancer Res. 2000. PMID: 10667590
The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistochemical studies of the retinoblastoma family of proteins in 235 specimens of lung cancer show the tightest inverse association between the h …
The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistoc …
The RB2/p130 gene: the latest weapon in the war against lung cancer?
Claudio PP, Caputi M, Giordano A. Claudio PP, et al. Clin Cancer Res. 2000 Mar;6(3):754-64. Clin Cancer Res. 2000. PMID: 10741694 Review.
It is important then to detect lung cancer at an earlier stage, studying and identifying genetic lesions that could indicate a new target(s) for gene therapy. The retinoblastoma-related gene pRb2/p130, a new tumor suppressor gene cloned in 1993, is emerging as one of the c …
It is important then to detect lung cancer at an earlier stage, studying and identifying genetic lesions that could indicate a new target(s) …
RB family members as predictive and prognostic factors in human cancer.
Scambia G, Lovergine S, Masciullo V. Scambia G, et al. Oncogene. 2006 Aug 28;25(38):5302-8. doi: 10.1038/sj.onc.1209620. Oncogene. 2006. PMID: 16936751
The retinoblastoma family members--pRb, pRb2/p130 and p107--are tumor suppressor genes involved in controlling four major cellular processes: growth arrest, apoptosis, differentiation and angiogenesis. ...
The retinoblastoma family members--pRb, pRb2/p130 and p107--are tumor suppressor genes involved in controlling four major cellular pr …
Tumor-specific exon 1 mutations could be the 'hit event' predisposing Rb2/p130 gene to epigenetic silencing in lung cancer.
Cinti C, Macaluso M, Giordano A. Cinti C, et al. Oncogene. 2005 Sep 1;24(38):5821-6. doi: 10.1038/sj.onc.1208880. Oncogene. 2005. PMID: 16044156
Genetic alterations in Rb2/p130 gene have been reported in several tumors, but till now there are insufficient and conflicting data linking the loss of pRb2/p130 expression with the mutational status of this gene in lung cancer. We recently reported that loss or lowering o …
Genetic alterations in Rb2/p130 gene have been reported in several tumors, but till now there are insufficient and conflicting data linking …