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1,214 results

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Page 1
Targeted disruption of PRC1.1 complex enhances bone remodeling.
Xing L, Xu J, Gong M, Liu Y, Li X, Meng L, Du R, Zhou Y, Ouyang Z, Liu X, Tao S, Cao Y, Liu C, Gao F, Han R, Shen H, Dong Y, Xu Y, Li T, Chen H, Zhao Y, Fan B, Sui L, Feng S, Liu J, Liu D, Wu X. Xing L, et al. Nat Commun. 2025 May 8;16(1):4294. doi: 10.1038/s41467-025-59638-w. Nat Commun. 2025. PMID: 40341537 Free PMC article.
Here in aging osteoblasts, we found marked activation of PRC1.1 complex, with KDM2B acting as a chromatin-binding factor and BCOR and PCGF1 enabling histone H2A monoubiquitylation (H2AK119ub1). ...Therefore, our findings identify PRC1.1 as a critical epigenet …
Here in aging osteoblasts, we found marked activation of PRC1.1 complex, with KDM2B acting as a chromatin-binding factor and B …
PRC1 complex diversity: where is it taking us?
Gil J, O'Loghlen A. Gil J, et al. Trends Cell Biol. 2014 Nov;24(11):632-41. doi: 10.1016/j.tcb.2014.06.005. Epub 2014 Jul 22. Trends Cell Biol. 2014. PMID: 25065329 Review.
Recent reports have found that the composition of mammalian Polycomb repressive complex 1 (PRC1) is far more varied than previously thought. PRC1 diversity largely depends on the presence of CBX proteins, dividing them into canonical and non-canonical, the ex …
Recent reports have found that the composition of mammalian Polycomb repressive complex 1 (PRC1) is far more varied than previ …
The Polycomb complex PRC2 and its mark in life.
Margueron R, Reinberg D. Margueron R, et al. Nature. 2011 Jan 20;469(7330):343-9. doi: 10.1038/nature09784. Nature. 2011. PMID: 21248841 Free PMC article. Review.
Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). …
Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin …
The molecular principles of gene regulation by Polycomb repressive complexes.
Blackledge NP, Klose RJ. Blackledge NP, et al. Nat Rev Mol Cell Biol. 2021 Dec;22(12):815-833. doi: 10.1038/s41580-021-00398-y. Epub 2021 Aug 16. Nat Rev Mol Cell Biol. 2021. PMID: 34400841 Free PMC article. Review.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the activity of the transcription machinery to genes, it has also become clear that chromatin and histone post-translational modification have fundamental roles in gene regulation. Polycomb r …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the activity of the transcription machinery to gene …
PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing.
Rodríguez TC, Yurkovetskiy L, Nagalekshmi K, Lam CHO, Jazbec E, Maitland SA, Wolfe SA, Sontheimer EJ, Luban J. Rodríguez TC, et al. bioRxiv [Preprint]. 2024 Jul 13:2024.07.12.603173. doi: 10.1101/2024.07.12.603173. bioRxiv. 2024. PMID: 39026796 Free PMC article. Preprint.
A forward genetic screen confirmed that PRC1.6 components L3MBTL2 and MGA contribute to HUSH complex-mediated silencing. PRC1.6 was then shown to silence HUSH-sensitive proviruses in a promoter-specific manner. Genome wide profiling showed striking colocaliza …
A forward genetic screen confirmed that PRC1.6 components L3MBTL2 and MGA contribute to HUSH complex-mediated silencing. PR …
Polycomb Repressor Complex 1 (PRC1) in ovarian cancer: A scoping literature review.
Floyd J, DeSanto K, Bitler BG, Brubaker LW. Floyd J, et al. Crit Rev Oncol Hematol. 2024 Oct;202:104456. doi: 10.1016/j.critrevonc.2024.104456. Epub 2024 Jul 19. Crit Rev Oncol Hematol. 2024. PMID: 39033867
The mechanism of this chemoresistance is not fully elucidated, but it is partly attributed to the ability of HGSC to maintain a stem-like phenotype that enables development of resistance to current therapies. Polycomb Repressor Complexes 1 and 2 (PRC1/2) have been i …
The mechanism of this chemoresistance is not fully elucidated, but it is partly attributed to the ability of HGSC to maintain a stem-like ph …
[Controlling the spatiotemporal expression of germ line specific genes by PRC1.6 complex].
Sun XW, Li HY, Wang J, Cheng B. Sun XW, et al. Yi Chuan. 2019 Apr 20;41(4):271-284. doi: 10.16288/j.yczz.18-332. Yi Chuan. 2019. PMID: 30992249 Review. Chinese.
Polycomb repressive complex 1 (PRC1) is a class of epigenetic regulatory complexes that normally represses gene expression by catalyzing and/or recognizing chromatin modifications. ...Mammalian PRC1 complexes are divided into six subtypes based …
Polycomb repressive complex 1 (PRC1) is a class of epigenetic regulatory complexes that normally represses gene express …
The polycomb complex PRC1: composition and function in plants.
Molitor A, Shen WH. Molitor A, et al. J Genet Genomics. 2013 May 20;40(5):231-8. doi: 10.1016/j.jgg.2012.12.005. Epub 2013 Jan 3. J Genet Genomics. 2013. PMID: 23706298 Review.
Polycomb group (PcG) proteins are crucial epigenetic regulators conferring transcriptional memory to cell lineages. They assemble into multi-protein complexes, e.g., Polycomb Repressive Complex 1 and 2 (PRC1, PRC2), which are thought to act in a sequential ma …
Polycomb group (PcG) proteins are crucial epigenetic regulators conferring transcriptional memory to cell lineages. They assemble into multi …
BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation.
Conway E, Rossi F, Fernandez-Perez D, Ponzo E, Ferrari KJ, Zanotti M, Manganaro D, Rodighiero S, Tamburri S, Pasini D. Conway E, et al. Mol Cell. 2021 Sep 2;81(17):3526-3541.e8. doi: 10.1016/j.molcel.2021.06.020. Epub 2021 Jun 28. Mol Cell. 2021. PMID: 34186021 Free PMC article.
It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcriptional repression. ...Loss of BAP1 results in a broad increase in H2AK119ub1 levels that is primarily dependent on PCGF3/5-PRC1 co …
It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcrip …
Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation.
Li T, Zhao Y, Li Q, Sun Z, Wang N, Xing L, Tang N, Mao R, Wang Y, Su J, Huo D, Dong F, Zhao X, Cao L, Kong Y, Gong M, Liu Z, Li W, Lv X, Ning H, Hu D, Zhou Y, Li B, Feng X, Helin K, Chen FX, Wu X. Li T, et al. Mol Cell. 2025 Jul 3;85(13):2517-2534.e6. doi: 10.1016/j.molcel.2025.05.029. Epub 2025 Jun 16. Mol Cell. 2025. PMID: 40527320
Mechanistically, PRC1.1 deposits H2AK119 monoubiquitylation (H2AK119ub1) at active promoters, enabling rather than repressing transcriptional activation of aTreg programs. ...Therefore, our study underscores H2AK119ub1 as a dual-function epigenetic mark and PRC1.1 a …
Mechanistically, PRC1.1 deposits H2AK119 monoubiquitylation (H2AK119ub1) at active promoters, enabling rather than repressing transcr …
1,214 results