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228 results

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Page 1
Identification of PROK2 gene polymorphisms as predictors of methamphetamine use disorder risk and indicators of craving scale in the Chinese Han population.
Jiang Z, Zhang T, Han W, Xiao J, Zhang W, Wang X, Liu J, Yang Y, Yang C, Guan F, Li T, Rice JP. Jiang Z, et al. Front Pharmacol. 2023 Jul 6;14:1217382. doi: 10.3389/fphar.2023.1217382. eCollection 2023. Front Pharmacol. 2023. PMID: 37484015 Free PMC article.
The aim of our study was to evaluate the correlation between the PROK2 gene and both MUD risk susceptibility and craving scale in the Chinese Han population. Methods: A total of 5,282 participants (1,796 MUD patients and 3,486 controls) were recruited. Seven tag SNP …
The aim of our study was to evaluate the correlation between the PROK2 gene and both MUD risk susceptibility and craving scale …
Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency.
Balasubramanian R, Crowley WF Jr. Balasubramanian R, et al. 2007 May 23 [updated 2022 May 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2007 May 23 [updated 2022 May 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301509 Free Books & Documents. Review.
DIAGNOSIS/TESTING: IGD is typically diagnosed in adolescents presenting with absent or partial puberty using biochemical testing that reveals low serum testosterone or estradiol (hypogonadism) that results from complete or partial absence of GnRH-mediated release of LH and FSH (h …
DIAGNOSIS/TESTING: IGD is typically diagnosed in adolescents presenting with absent or partial puberty using biochemical testing that reveal …
Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.
Bao Z, Liu Y, Chen B, Miao Z, Tu Y, Li C, Chao H, Ye Y, Xu X, Sun G, Zhao P, Liu N, Liu Y, Wang X, Lam SM, Kagan VE, Bayır H, Ji J. Bao Z, et al. Nat Commun. 2021 Jul 9;12(1):4220. doi: 10.1038/s41467-021-24469-y. Nat Commun. 2021. PMID: 34244497 Free PMC article.
Prokineticin-2 (Prok2) is an important secreted protein likely involved in the pathogenesis of several acute and chronic neurological diseases through currently unidentified regulatory mechanisms. ...Our study shows that Prok2 mediates neuronal cell deaths in trauma …
Prokineticin-2 (Prok2) is an important secreted protein likely involved in the pathogenesis of several acute and chronic neurological …
Prokineticin 2 (PROK2) is an important factor for angiogenesis in colorectal cancer.
Kurebayashi H, Goi T, Shimada M, Tagai N, Naruse T, Nakazawa T, Kimura Y, Hirono Y, Yamaguchi A. Kurebayashi H, et al. Oncotarget. 2015 Sep 22;6(28):26242-51. doi: 10.18632/oncotarget.4385. Oncotarget. 2015. PMID: 26317645 Free PMC article.
For investigating angiogenesis and tumor growth in mice, the PROK2 gene was transfected into colorectal cancer cell lines having low PROK2 mRNA expression. ...When the PROK2 gene was transfected into the colorectal cancer cell line with low P …
For investigating angiogenesis and tumor growth in mice, the PROK2 gene was transfected into colorectal cancer cell lines havi …
Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes: pathophysiology and genotype-phenotype correlations.
Sarfati J, Dodé C, Young J. Sarfati J, et al. Front Horm Res. 2010;39:121-132. doi: 10.1159/000312698. Epub 2010 Apr 8. Front Horm Res. 2010. PMID: 20389090 Review.
Prok2 and prokr2 gene knockout mice both have agenesis or hypoplasia of the olfactory bulbs, associated with hypogonadotropic hypogonadism linked to abnormal GnRH neuron migration. Prok2-/- and prokr2-/- mice are the first murine models of this human disease. …
Prok2 and prokr2 gene knockout mice both have agenesis or hypoplasia of the olfactory bulbs, associated with hypogonadotropic …
Silencing PROK2 Inhibits Invasion of Human Cervical Cancer Cells by Targeting MMP15 Expression.
Wu MH, Wu PR, Hsieh YH, Lin CL, Liu CJ, Ying TH. Wu MH, et al. Int J Mol Sci. 2020 Sep 2;21(17):6391. doi: 10.3390/ijms21176391. Int J Mol Sci. 2020. PMID: 32887509 Free PMC article.
Our results indicate that PROK2 is overexpressed in the human cervical cancer. Cervical cancer patients with high PROK2 expression have a shorter overall survival rate (OS) and disease-free survival rate (DFS). ...High expression of MMP15 is confirmed in the human c …
Our results indicate that PROK2 is overexpressed in the human cervical cancer. Cervical cancer patients with high PROK2 expres …
Inferring circadian gene regulatory relationships from gene expression data with a hybrid framework.
Hu S, Jing Y, Li T, Wang YG, Liu Z, Gao J, Tian YC. Hu S, et al. BMC Bioinformatics. 2023 Sep 26;24(1):362. doi: 10.1186/s12859-023-05458-y. BMC Bioinformatics. 2023. PMID: 37752445 Free PMC article.
Through this approach, we efficiently identify the clusters of genes related to the target gene. To determine the significance of genes within a specific cluster, we employ the Wilcoxon signed-rank test. ...The results show that genes Pde10a, Atp7b, …
Through this approach, we efficiently identify the clusters of genes related to the target gene. To determine the significance …
Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data.
Zhan C, Zhou Z, Huang Y, Huang S, Lin Z, He F, Song Z. Zhan C, et al. Gastroenterol Rep (Oxf). 2023 Jul 14;11:goad041. doi: 10.1093/gastro/goad041. eCollection 2023. Gastroenterol Rep (Oxf). 2023. PMID: 37456714 Free PMC article.
The immune response is the common feature of the two conditions, but the more precise mechanisms remain unclear. METHODS: Differential expressed genes (DEGs) analysis and weighted gene co-expression network analysis (WGCNA) were performed on PD and Crohn's disease ( …
The immune response is the common feature of the two conditions, but the more precise mechanisms remain unclear. METHODS: Differential expre …
The novel function of miR-3195 for mutant PROK2 (c.223-4C>A) degradation.
Zhou S, Li P. Zhou S, et al. Cell Biol Int. 2021 Feb;45(2):404-410. doi: 10.1002/cbin.11496. Epub 2020 Nov 10. Cell Biol Int. 2021. PMID: 33140874
Kallmann syndrome (KS) is a rare human genetic disorder characterized by hypogonadotropic hypogonadism with the reduction or absence of olfactory sense. Mutations in multiple genes, including chemokine prokineticin-2 (PROK2), are considered to contribute to the abno …
Kallmann syndrome (KS) is a rare human genetic disorder characterized by hypogonadotropic hypogonadism with the reduction or absence of olfa …
ANALYSIS AND IDENTIFICATION OF FERROPTOSIS-RELATED GENE SIGNATURE FOR ACUTE LUNG INJURY.
Wang J, Yue XQ, Li YT, Jiang M, Liu JC, Zhao ZG, Niu CY. Wang J, et al. Shock. 2024 May 1;61(5):728-739. doi: 10.1097/SHK.0000000000002247. Epub 2023 Oct 2. Shock. 2024. PMID: 37878471
The current study analyzed and identified a ferroptosis-related gene signature for ALI. Methods: Key genes associated with ferroptosis in ALI were identified by bioinformatics analysis. ...We intersected nine signature genes with WGCNA module genes and …
The current study analyzed and identified a ferroptosis-related gene signature for ALI. Methods: Key genes associated with fer …
228 results