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PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication.
Hui X, Cao L, Xu T, Zhao L, Huang K, Zou Z, Ren P, Mao H, Yang Y, Gao S, Sun X, Lin X, Jin M. Hui X, et al. J Virol. 2022 Aug 10;96(15):e0078622. doi: 10.1128/jvi.00786-22. Epub 2022 Jul 21. J Virol. 2022. PMID: 35861516 Free PMC article.
Mechanistically, PSMD12 promoted M1-M2 virus-like particle (VLP) release, and an M1-K102 mutation disrupted the formation of supernatant M1-M2 VLPs. ...PSMD12 promoted M1-M2 VLP egress, and an M1-K102 mutation affected the M1-M2 VLP formation. ...
Mechanistically, PSMD12 promoted M1-M2 virus-like particle (VLP) release, and an M1-K102 mutation disrupted the formation of supernat …
PSMD12 promotes hepatocellular carcinoma progression by stabilizing CDK1.
Peng X, Liu Z, Luo C, Sun R, Zhang Y, Li B, Zou Y, Zhu J, Yuan R. Peng X, et al. Front Immunol. 2025 Jun 4;16:1581398. doi: 10.3389/fimmu.2025.1581398. eCollection 2025. Front Immunol. 2025. PMID: 40534847 Free PMC article.
Proteasome 26S subunit non-ATPase 12 (PSMD12), a critical subunit of the proteasome system, is essential for maintaining protein homeostasis. ...In contrast, PSMD12 overexpression promoted these malignant behaviors. Mechanistically, PSMD12 interacts with cycl …
Proteasome 26S subunit non-ATPase 12 (PSMD12), a critical subunit of the proteasome system, is essential for maintaining protein home …
PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway.
Lv J, Ma S, Wang X, Dang J, Ma F. Lv J, et al. Genes Genomics. 2024 Mar;46(3):263-277. doi: 10.1007/s13258-023-01484-5. Epub 2024 Jan 19. Genes Genomics. 2024. PMID: 38243044
PSMD12 knockdown significantly suppressed malignant behaviors of NSCLC cells, including cell growth, invasion, and migration, while PSMD12 overexpression presented the opposite effects. Interestingly, we found that PSMD12 upregulated the tumor-promoting facto …
PSMD12 knockdown significantly suppressed malignant behaviors of NSCLC cells, including cell growth, invasion, and migration, while …
PSMD12 interacts with CDKN3 and facilitates pancreatic cancer progression.
Ma J, Zhou W, Yuan Y, Wang B, Meng X. Ma J, et al. Cancer Gene Ther. 2023 Aug;30(8):1072-1083. doi: 10.1038/s41417-023-00609-y. Epub 2023 Apr 10. Cancer Gene Ther. 2023. PMID: 37037907
Proteasome 26S subunit, non-ATPase 12 (PSMD12) genes have been implicated in several types of malignancies but the role of PSMD12 in pancreatic cancer (PC) remains elusive. ...PSMD12 knockdown promoted cell apoptosis. The results of xenografts in nude mice co …
Proteasome 26S subunit, non-ATPase 12 (PSMD12) genes have been implicated in several types of malignancies but the role of PSMD12 …
Integrating multi-omics to unveil PSMD12 as a critical gene in promoting brain metastases of lung adenocarcinoma.
Li X, Zhang J, Zhang M, Jiang W, Jia D, Wang R, Li H, Wang Z, Liu Y, Tang L, Deng J, Zhao W, Yu Y, Liu S, Qi L. Li X, et al. J Transl Med. 2025 Jun 17;23(1):668. doi: 10.1186/s12967-025-06680-3. J Transl Med. 2025. PMID: 40528170 Free PMC article.
We also developed an in vitro blood-brain barrier (BBB) model to investigate the disruption of PSMD12 on the barrier. Mechanistically, we developed an algorithm to construct an upstream regulator network of PSMD12 overexpression. ...Functional experiments revealed t …
We also developed an in vitro blood-brain barrier (BBB) model to investigate the disruption of PSMD12 on the barrier. Mechanistically …
PSMD12 promotes breast cancer growth via inhibiting the expression of pro-apoptotic genes.
Du X, Shen X, Dai L, Bi F, Zhang H, Lu C. Du X, et al. Biochem Biophys Res Commun. 2020 May 28;526(2):368-374. doi: 10.1016/j.bbrc.2020.03.095. Epub 2020 Mar 25. Biochem Biophys Res Commun. 2020. PMID: 32222279
Notably, the expression of PSMD12 increased in the nucleus. Cytological experiments revealed that PSMD12 knockdown inhibited cell growth and migration, and a genome-wide CRISPR-Cas9 knockout (GeCKO) screen also confirmed that PSMD12 is a crucial gene for the …
Notably, the expression of PSMD12 increased in the nucleus. Cytological experiments revealed that PSMD12 knockdown inhibited c …
PSMD12 promotes glioma progression by upregulating the expression of Nrf2.
Wang Z, Li Z, Xu H, Liao Y, Sun C, Chen Y, Sheng M, Lan Q, Wang Z. Wang Z, et al. Ann Transl Med. 2021 Apr;9(8):700. doi: 10.21037/atm-21-1481. Ann Transl Med. 2021. PMID: 33987398 Free PMC article.
PSMD12 upregulation was associated with poor prognosis in glioma patients. Knockdown of PSMD12 inhibited the growth of glioma cells in vitro and in vivo and decreased their invasion ability, whereas PSMD12 overexpression had the opposite effect. ...Similar to …
PSMD12 upregulation was associated with poor prognosis in glioma patients. Knockdown of PSMD12 inhibited the growth of glioma …
Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction and Subclinical Autoinflammation.
Yan K, Zhang J, Lee PY, Tao P, Wang J, Wang S, Zhou Q, Dong M. Yan K, et al. Arthritis Rheumatol. 2022 Jun;74(6):1083-1090. doi: 10.1002/art.42070. Epub 2022 Apr 23. Arthritis Rheumatol. 2022. PMID: 35080150 Free PMC article.
We performed functional studies to assess proteasome dysfunction and inflammatory signatures in patients, and single-cell RNA sequencing to further explore the spectrum of immune cell activation. RESULTS: A novel truncated variant in PSMD12 (c.865C>T, p.Arg289*) was ide …
We performed functional studies to assess proteasome dysfunction and inflammatory signatures in patients, and single-cell RNA sequencing to …
PSMD12 haploinsufficiency in a neurodevelopmental disorder with autistic features.
Khalil R, Kenny C, Hill RS, Mochida GH, Nasir R, Partlow JN, Barry BJ, Al-Saffar M, Egan C, Stevens CR, Gabriel SB, Barkovich AJ, Ellison JW, Al-Gazali L, Walsh CA, Chahrour MH. Khalil R, et al. Am J Med Genet B Neuropsychiatr Genet. 2018 Dec;177(8):736-745. doi: 10.1002/ajmg.b.32688. Epub 2018 Nov 13. Am J Med Genet B Neuropsychiatr Genet. 2018. PMID: 30421579 Free PMC article.
We identified an inherited heterozygous nonsense mutation in PSMD12 (NM_002816: c.367C>T: p.R123X) in the multiplex family and a de novo nonsense mutation in the same gene (NM_002816: c.601C>T: p.R201X) in the simplex family. PSMD12 encodes a non-ATPase regula …
We identified an inherited heterozygous nonsense mutation in PSMD12 (NM_002816: c.367C>T: p.R123X) in the multiplex family and a d …
PSMD12 Overexpression Promotes Lung Adenocarcinoma Progression via Ubiquitin-Proteasome Pathway Dysregulation.
Ono Y, Otsu H, Masuda T, Kosai K, Shibuta S, Hirose K, Ofuchi T, Ando Y, Kawata K, Tsuda Y, Yonemura Y, Tobo T, Takenaka T, Yoshizumi T, Mimori K. Ono Y, et al. Cancer Sci. 2026 Mar;117(3):644-656. doi: 10.1111/cas.70290. Epub 2026 Jan 6. Cancer Sci. 2026. PMID: 41496578 Free PMC article.
High PSMD12 expression was associated with poor prognosis and advanced pathological stages. ...Cycloheximide chase and MG132 assays confirmed that PSMD12 stabilized CDK1 by inhibiting proteasome-mediated degradation. In conclusion, we identified PSMD12 as a n …
High PSMD12 expression was associated with poor prognosis and advanced pathological stages. ...Cycloheximide chase and MG132 assays c …
53 results