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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1998 15
1999 21
2000 39
2001 40
2002 32
2003 64
2004 83
2005 75
2006 90
2007 100
2008 129
2009 138
2010 125
2011 145
2012 123
2013 183
2014 210
2015 191
2016 147
2017 162
2018 152
2019 174
2020 206
2021 218
2022 163
2023 37
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2,729 results
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Page 1
PTEN: Tumor Suppressor and Metabolic Regulator.
Chen CY, Chen J, He L, Stiles BL. Chen CY, et al. Front Endocrinol (Lausanne). 2018 Jul 9;9:338. doi: 10.3389/fendo.2018.00338. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30038596 Free PMC article. Review.
In this review, we introduced the discovery of PTEN, the PTEN-regulated canonical and nuclear signals, and PTEN regulation. We then focused on the role of PTEN and PTEN-regulated signals in metabolic regulation. This included the role of PTEN …
In this review, we introduced the discovery of PTEN, the PTEN-regulated canonical and nuclear signals, and PTEN regulat …
PTEN in Autism and Neurodevelopmental Disorders.
Rademacher S, Eickholt BJ. Rademacher S, et al. Cold Spring Harb Perspect Med. 2019 Nov 1;9(11):a036780. doi: 10.1101/cshperspect.a036780. Cold Spring Harb Perspect Med. 2019. PMID: 31427284 Free PMC article. Review.
Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes phosphatidylinositol 3-phosphate kinase (PI3K)/AKT signaling. ...To investigate PTEN's role during neurodevelopment and its implication for autism, several conditional Pten …
Phosphatase and tensin homolog (PTEN) is a classical tumor suppressor that antagonizes phosphatidylinositol 3-phosphate kinase (PI3K) …
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Pilarski R, et al. J Natl Cancer Inst. 2013 Nov 6;105(21):1607-16. doi: 10.1093/jnci/djt277. Epub 2013 Oct 17. J Natl Cancer Inst. 2013. PMID: 24136893 Review.
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (PTEN) gene. Diagnostic criteria for Cowden syndrome, the principal PTEN-related disorder, were first established in 1 …
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin …
MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review).
Hu M, Zhu S, Xiong S, Xue X, Zhou X. Hu M, et al. Oncol Rep. 2019 Mar;41(3):1439-1454. doi: 10.3892/or.2019.6962. Epub 2019 Jan 10. Oncol Rep. 2019. PMID: 30628706 Review.
Therefore, in the present review, the disorder and function of miRNAs and PTEN/PI3K/Akt signaling in GC are discussed. Additionally, how miRNAs transduce their effects by regulating this pathway, particularly in GC stem cells and the tumor microenvironment, and two novel h …
Therefore, in the present review, the disorder and function of miRNAs and PTEN/PI3K/Akt signaling in GC are discussed. Additionally, …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects.
Lee YR, Chen M, Pandolfi PP. Lee YR, et al. Nat Rev Mol Cell Biol. 2018 Sep;19(9):547-562. doi: 10.1038/s41580-018-0015-0. Nat Rev Mol Cell Biol. 2018. PMID: 29858604 Review.
Regulation of PTEN has therefore emerged as a subject of intense research in tumour biology. Recent discoveries, including the existence of distinct PTEN isoforms and the ability of PTEN to form dimers, have brought to light new modes of PTEN function …
Regulation of PTEN has therefore emerged as a subject of intense research in tumour biology. Recent discoveries, including the existe …
PTEN, Insulin Resistance and Cancer.
Li A, Qiu M, Zhou H, Wang T, Guo W. Li A, et al. Curr Pharm Des. 2017;23(25):3667-3676. doi: 10.2174/1381612823666170704124611. Curr Pharm Des. 2017. PMID: 28677502 Review.
BACKGROUND: The tumor suppressor PTEN serves as a negative regulator of PI3K/PTEN/Akt signaling pathway that regulates cellular functions such as cell growth, differentiation, proliferation and migration. ...Selective disruption of PTEN in pancreatic alpha-ce …
BACKGROUND: The tumor suppressor PTEN serves as a negative regulator of PI3K/PTEN/Akt signaling pathway that regulates cellula …
PTEN.
Worby CA, Dixon JE. Worby CA, et al. Annu Rev Biochem. 2014;83:641-69. doi: 10.1146/annurev-biochem-082411-113907. Annu Rev Biochem. 2014. PMID: 24905788 Review.
The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid phosphatase activity, which opposes PI3K/AKT activation. ...
The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppress …
Mechanisms of PTEN loss in cancer: It's all about diversity.
Álvarez-Garcia V, Tawil Y, Wise HM, Leslie NR. Álvarez-Garcia V, et al. Semin Cancer Biol. 2019 Dec;59:66-79. doi: 10.1016/j.semcancer.2019.02.001. Epub 2019 Feb 7. Semin Cancer Biol. 2019. PMID: 30738865 Review.
Although the mechanisms by which PTEN function is disrupted are diverse, the most frequently observed events are deletion of a single gene copy of PTEN and gene silencing, usually observed in tumours with little or no PTEN protein detectable by immunohistoche …
Although the mechanisms by which PTEN function is disrupted are diverse, the most frequently observed events are deletion of a single …
The Clinical Spectrum of PTEN Mutations.
Yehia L, Keel E, Eng C. Yehia L, et al. Annu Rev Med. 2020 Jan 27;71:103-116. doi: 10.1146/annurev-med-052218-125823. Epub 2019 Aug 21. Annu Rev Med. 2020. PMID: 31433956 Review.
PTEN is a tumor suppressor gene that classically dampens the PI3K/AKT/mTOR growth-promoting signaling cascade. PTEN dysfunction causes dysregulation of this and other pathways, resulting in overgrowth. ...
PTEN is a tumor suppressor gene that classically dampens the PI3K/AKT/mTOR growth-promoting signaling cascade. PTEN dysfunctio …
Prostate cancer, PI3K, PTEN and prognosis.
Wise HM, Hermida MA, Leslie NR. Wise HM, et al. Clin Sci (Lond). 2017 Feb 1;131(3):197-210. doi: 10.1042/CS20160026. Clin Sci (Lond). 2017. PMID: 28057891 Review.
The observed mechanisms of PTEN loss are diverse, but both homozygous and heterozygous genomic deletions including PTEN are frequent, and often accompanied by loss of detectable protein as assessed by immunohistochemistry (IHC). The occurrence of PTEN loss is …
The observed mechanisms of PTEN loss are diverse, but both homozygous and heterozygous genomic deletions including PTEN are fr …
2,729 results