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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 5
1999 16
2000 29
2001 44
2002 48
2003 37
2004 57
2005 62
2006 77
2007 86
2008 79
2009 68
2010 78
2011 72
2012 78
2013 89
2014 111
2015 97
2016 76
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2022 69
2023 16
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1,479 results
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Page 1
Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions.
Tu T, Chen J, Chen L, Stiles BL. Tu T, et al. Cold Spring Harb Perspect Med. 2020 Jan 2;10(1):a036301. doi: 10.1101/cshperspect.a036301. Cold Spring Harb Perspect Med. 2020. PMID: 31548229 Free PMC article. Review.
Crystal structure analysis of PTEN has revealed a C2 domain that binds to phospholipids in membranes and a phosphatase domain that displays dual-specific activity toward both tyrosine (Y), serine (S)/threonine (T), as well as lipid substrates in vitro. …
Crystal structure analysis of PTEN has revealed a C2 domain that binds to phospholipids in membranes and a phosphatase domain …
PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling.
Liu B, Gao TT, Fu XY, Xu ZH, Ren H, Zhao P, Qi ZT, Qin ZL. Liu B, et al. Virol Sin. 2021 Jun;36(3):412-423. doi: 10.1007/s12250-020-00291-6. Epub 2020 Oct 12. Virol Sin. 2021. PMID: 33044659 Free PMC article.
In this study, we reveal a novel role for phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in LDs-mediated DENV infection. ...PTEN lipid phosphatase activity was found to decrease cellular LDs area and number through Akt/FoxO1/Maf1 …
In this study, we reveal a novel role for phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in LDs-mediated DENV …
PTEN.
Worby CA, Dixon JE. Worby CA, et al. Annu Rev Biochem. 2014;83:641-69. doi: 10.1146/annurev-biochem-082411-113907. Annu Rev Biochem. 2014. PMID: 24905788 Review.
The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid phosphatase activity, which opposes PI3K/AKT activation. ...
The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppress …
Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.
Eng C. Eng C. Ann N Y Acad Sci. 2002 Jun;968:213-21. doi: 10.1111/j.1749-6632.2002.tb04337.x. Ann N Y Acad Sci. 2002. PMID: 12119278 Review.
Both benign and malignant thyroid disease are well-established components of Cowden syndrome (CS), an autosomal dominant disorder characterized by multiple hamartomas and breast cancer that may be considered a phakomatosis. The susceptibility gene for CS is PTEN, a tumor s …
Both benign and malignant thyroid disease are well-established components of Cowden syndrome (CS), an autosomal dominant disorder characteri …
Pharmacological inhibition of the lipid phosphatase PTEN ameliorates heart damage and adipose tissue inflammation in stressed rats with metabolic syndrome.
Ashikawa S, Komatsu Y, Kawai Y, Aoyama K, Nakano S, Cui X, Hayakawa M, Sakabe N, Furukawa N, Ikeda K, Murohara T, Nagata K. Ashikawa S, et al. Physiol Rep. 2022 Jan;10(1):e15165. doi: 10.14814/phy2.15165. Physiol Rep. 2022. PMID: 35005845 Free PMC article.
Phosphatidylinositol 3-kinase (PI3K) signaling promotes the differentiation and proliferation of regulatory B (Breg) cells, and the lipid phosphatase phosphatase and tensin homolog deleted on chromosome 10 (PTEN) antagonizes the PI3K-Akt signaling path …
Phosphatidylinositol 3-kinase (PI3K) signaling promotes the differentiation and proliferation of regulatory B (Breg) cells, and the lipid …
Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.
Stumpf M, den Hertog J. Stumpf M, et al. PLoS One. 2016 Feb 5;11(2):e0148508. doi: 10.1371/journal.pone.0148508. eCollection 2016. PLoS One. 2016. PMID: 26848951 Free PMC article.
The lipid- and protein phosphatase PTEN is one of the most frequently mutated tumor suppressor genes in human cancers and many mutations found in tumor samples directly affect PTEN phosphatase activity. ...We propose that the role of Pten …
The lipid- and protein phosphatase PTEN is one of the most frequently mutated tumor suppressor genes in human cancers a …
Assays to Measure PTEN Lipid Phosphatase Activity In Vitro from Purified Enzyme or Immunoprecipitates.
Spinelli L, Leslie NR. Spinelli L, et al. Methods Mol Biol. 2016;1447:95-105. doi: 10.1007/978-1-4939-3746-2_6. Methods Mol Biol. 2016. PMID: 27514802
Sensitive phosphatase assays are employed to study the catalytic activity of PTEN against phospholipid substrates. Here we describe protocols to assay PTEN lipid phosphatase activity using either purified enzyme (purified PTEN lipid …
Sensitive phosphatase assays are employed to study the catalytic activity of PTEN against phospholipid substrates. Here we des …
PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate.
Wise HM, Harris A, Kriplani N, Schofield A, Caldwell H, Arends MJ, Overton IM, Leslie NR. Wise HM, et al. Biomolecules. 2022 Oct 19;12(10):1511. doi: 10.3390/biom12101511. Biomolecules. 2022. PMID: 36291720 Free PMC article.
Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid phosphatase which opposes the activation of the oncogenic PI3K-AKT signalling network. However, PTEN also has additional p …
Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid …
The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasiveness.
Kotelevets L, van Hengel J, Bruyneel E, Mareel M, van Roy F, Chastre E. Kotelevets L, et al. J Cell Biol. 2001 Dec 24;155(7):1129-35. doi: 10.1083/jcb.200105109. Epub 2001 Dec 24. J Cell Biol. 2001. PMID: 11756467 Free PMC article.
We demonstrate that ectopic expression of wild-type PTEN in MDCKts-src cells, but not expression of PTEN mutants deficient in either the lipid or both the lipid and protein phosphatase activities, reverted the morphological transformation, induc …
We demonstrate that ectopic expression of wild-type PTEN in MDCKts-src cells, but not expression of PTEN mutants deficient in …
Biophysical methods for the characterization of PTEN/lipid bilayer interactions.
Harishchandra RK, Neumann BM, Gericke A, Ross AH. Harishchandra RK, et al. Methods. 2015 May;77-78:125-35. doi: 10.1016/j.ymeth.2015.02.004. Epub 2015 Feb 16. Methods. 2015. PMID: 25697761 Free PMC article. Review.
Upon membrane association PTEN interacts with at least three different lipid entities: An anionic lipid that is present in sufficiently high concentration to create a negative potential that allows PTEN to interact electrostatically with the membrane, …
Upon membrane association PTEN interacts with at least three different lipid entities: An anionic lipid that is present …
1,479 results