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2003 1
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26 results

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Page 1
PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis.
Li C, Li SZ, Huang XC, Chen J, Liu W, Zhang XD, Song XM, Du RL. Li C, et al. Genes Dis. 2020 Aug 25;8(6):838-848. doi: 10.1016/j.gendis.2020.08.001. eCollection 2021 Nov. Genes Dis. 2020. PMID: 34522712 Free PMC article.
Protein tyrosine phosphatase non-receptor type 18 (PTPN18) is often highly expressed in colorectal cancer (CRC), but its role in this disease remains unclear. ...Moreover, a xenograft assay showed that PTPN18 deficiency significantly inhibited tumorigenesis i …
Protein tyrosine phosphatase non-receptor type 18 (PTPN18) is often highly expressed in colorectal cancer (CRC), but its role …
Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin beta2.
Wang T, Ba X, Zhang X, Zhang N, Wang G, Bai B, Li T, Zhao J, Zhao Y, Yu Y, Wang B. Wang T, et al. Cell Death Dis. 2022 Aug 18;13(8):720. doi: 10.1038/s41419-022-05167-z. Cell Death Dis. 2022. PMID: 35982039 Free PMC article.
Ectopic expression of PTPN18 inhibits breast cancer cell metastasis. PTPN18 is translocated from the cytoplasm to the nucleus by MVP and importin beta2 in breast cancer. ...Our data highlight PTPN18 as a suppressor of breast cancer metast …
Ectopic expression of PTPN18 inhibits breast cancer cell metastasis. PTPN18 is translocated from the cytoplasm to the n …
PTPN18 Stimulates the Development of Ovarian Cancer by Activating the PI3K/AKT Signaling.
Mao N, Li H, Yang H, Su J, Liang Z, He G. Mao N, et al. Evid Based Complement Alternat Med. 2022 Mar 11;2022:1091042. doi: 10.1155/2022/1091042. eCollection 2022. Evid Based Complement Alternat Med. 2022. Retraction in: Evid Based Complement Alternat Med. 2023 Jul 19;2023:9846528. doi: 10.1155/2023/9846528. PMID: 35310041 Free PMC article. Retracted.
Nude mice with ovarian cancer were used to uncover the effects of PTPN18 on ovarian cancer growth in vivo. RESULTS: PTPN18 was significantly upregulated in ovarian cancer samples and linked to pathological staging and metastasis rate. PTPN18 …
Nude mice with ovarian cancer were used to uncover the effects of PTPN18 on ovarian cancer growth in vivo. RESULTS: …
Silencing of PTPN18 Induced Ferroptosis in Endometrial Cancer Cells Through p-P38-Mediated GPX4/xCT Down-Regulation.
Wang H, Peng S, Cai J, Bao S. Wang H, et al. Cancer Manag Res. 2021 Feb 19;13:1757-1765. doi: 10.2147/CMAR.S278728. eCollection 2021. Cancer Manag Res. 2021. PMID: 33642877 Free PMC article.
PTPN18 is a member of the protein tyrosine phosphatases (PTP) family, which is associated with the occurrence and progression of various human cancers. PTPN18 was up-regulated in endometrial cancer tissues and high level of PTPN18 promoted proli …
PTPN18 is a member of the protein tyrosine phosphatases (PTP) family, which is associated with the occurrence and progression of vari …
PTPN18 functions as a tumor suppressor in breast cancer by negatively regulating cyclin E.
Zhang N, Wang T, Bai B, Zhang X, Xu W, Chen W, Yu Y, Wang B. Zhang N, et al. Int J Oncol. 2026 Mar;68(3):30. doi: 10.3892/ijo.2025.5843. Epub 2026 Jan 2. Int J Oncol. 2026. PMID: 41480706 Free PMC article.
Protein tyrosine phosphatase non-receptor 18 (PTPN18) is widely expressed in breast cancer (BC) cell lines. Additionally, high levels of PTPN18 facilitate an improved overall survival and prognosis in patients with BC. However, the effects and mechanisms of …
Protein tyrosine phosphatase non-receptor 18 (PTPN18) is widely expressed in breast cancer (BC) cell lines. Additionally, high …
Downregulation of PTPN18 can inhibit proliferation and metastasis and promote apoptosis of endometrial cancer.
Cai J, Huang S, Yi Y, Bao S. Cai J, et al. Clin Exp Pharmacol Physiol. 2019 Aug;46(8):734-742. doi: 10.1111/1440-1681.13098. Epub 2019 May 30. Clin Exp Pharmacol Physiol. 2019. PMID: 31034093
In our results, we found that PTPN18 was overexpressed in endometrial cancer tissue compared to paracancerous tissue by immunohistochemistry. ...Although the exact function of PTPN18 in endometrial cancer is unclear, the targeted therapy drugs enhancin …
In our results, we found that PTPN18 was overexpressed in endometrial cancer tissue compared to paracancerous tissue by immuno …
The R451 site is critical for PTPN18 to exert tumor suppressive effects in breast cancer through the negative regulatory interacting protein fibrillarin.
Zhang N, Wang T, Bai B, Zhang X, Xu W, Chen W, Yu Y, Wang B. Zhang N, et al. Cell Death Dis. 2026 Jan 20;17(1):168. doi: 10.1038/s41419-025-08395-1. Cell Death Dis. 2026. PMID: 41559020 Free PMC article.
As a result, the interaction between PTPN18 and FBL affects the proliferation and apoptosis of breast cancer cells, thus inhibiting tumor growth. This study reveals a novel mechanism through which PTPN18 inhibits breast cancer progression and further r …
As a result, the interaction between PTPN18 and FBL affects the proliferation and apoptosis of breast cancer cells, thus inhib …
Mechanism of PTPN18 for regulating the migration and invasion of endometrial cancer cells via the MYC/PI3K/AKT pathway.
Suo S, Chen S, Zhou L, Xu R, Li J, Li W. Suo S, et al. Histol Histopathol. 2025 Feb;40(2):215-223. doi: 10.14670/HH-18-767. Epub 2024 May 27. Histol Histopathol. 2025. PMID: 38855855
OBJECTIVE: Endometrial cancer (EC) is a prevalent gynecologic malignancy. The critical role of PTPN18 in EC has been reported, while its role in the aerobic glycolysis of EC cells remains unclear. ...RESULTS: Expression of PTPN18 in EC cells was up-regulated …
OBJECTIVE: Endometrial cancer (EC) is a prevalent gynecologic malignancy. The critical role of PTPN18 in EC has been reported, …
PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression.
Wang T, Yu Y, Ba X, Zhang X, Zhang N, Wang G, Bai B, Li T, Zhao J, Zhao Y, Wang B. Wang T, et al. Oxid Med Cell Longev. 2023 Feb 15;2023:2994316. doi: 10.1155/2023/2994316. eCollection 2023. Oxid Med Cell Longev. 2023. PMID: 36846716 Free PMC article.
Glioblastoma is characterized as one of the deadliest cancers in humans. The survival time is not improved by standard treatment. Although immunotherapy has revolutionized cancer treatment, the current therapy targets for glioblastoma patients are not satisfied. ... …
Glioblastoma is characterized as one of the deadliest cancers in humans. The survival time is not improved by standard treatment. Alt …
26 results