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Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.
Gangjee A, Li W, Kisliuk RL, Cody V, Pace J, Piraino J, Makin J. Gangjee A, et al. Among authors: pace j. J Med Chem. 2009 Aug 13;52(15):4892-902. doi: 10.1021/jm900490a. J Med Chem. 2009. PMID: 19719239 Free PMC article.
Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
Shah K, Lin X, Queener SF, Cody V, Pace J, Gangjee A. Shah K, et al. Among authors: pace j. Bioorg Med Chem. 2018 May 15;26(9):2640-2650. doi: 10.1016/j.bmc.2018.04.032. Epub 2018 Apr 17. Bioorg Med Chem. 2018. PMID: 29691153 Free PMC article.
Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine.
Cody V, Pace J, Rosowsky A. Cody V, et al. Among authors: pace j. Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):977-84. doi: 10.1107/S0907444908022348. Epub 2008 Aug 13. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18703847 Free PMC article.
Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.
Cody V, Piraino J, Pace J, Li W, Gangjee A. Cody V, et al. Among authors: pace j. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1271-7. doi: 10.1107/S0907444910035808. Epub 2010 Nov 16. Acta Crystallogr D Biol Crystallogr. 2010. PMID: 21123866 Free PMC article.
529 results