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Year Number of Results
1979 2
1980 1
1982 1
1986 1
1988 3
1989 3
1990 2
1991 3
1992 2
1993 1
1995 1
1997 2
1998 1
1999 1
2002 1
2004 1
2005 2
2007 2
2008 1
2009 1
2010 5
2011 5
2012 2
2013 3
2014 3
2015 3
2016 3
2017 4
2018 1
2019 6
2020 3
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2022 4
2023 6
2024 3

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78 results

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Page 1
PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.
Funk CR, Wang S, Chen KZ, Waller A, Sharma A, Edgar CL, Gupta VA, Chandrakasan S, Zoine JT, Fedanov A, Raikar SS, Koff JL, Flowers CR, Coma S, Pachter JA, Ravindranathan S, Spencer HT, Shanmugam M, Waller EK. Funk CR, et al. Among authors: pachter ja. Blood. 2022 Jan 27;139(4):523-537. doi: 10.1182/blood.2021011597. Blood. 2022. PMID: 35084470 Free PMC article.
High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma.
Arang N, Lubrano S, Ceribelli M, Rigiracciolo DC, Saddawi-Konefka R, Faraji F, Ramirez SI, Kim D, Tosto FA, Stevenson E, Zhou Y, Wang Z, Bogomolovas J, Molinolo AA, Swaney DL, Krogan NJ, Yang J, Coma S, Pachter JA, Aplin AE, Alessi DR, Thomas CJ, Gutkind JS. Arang N, et al. Among authors: pachter ja. Cell Rep Med. 2023 Nov 21;4(11):101244. doi: 10.1016/j.xcrm.2023.101244. Epub 2023 Oct 18. Cell Rep Med. 2023. PMID: 37858338 Free PMC article.
Preclinical efficacy of RAF/MEK clamp avutometinib in combination with FAK inhibition in low grade serous ovarian cancer.
McNamara B, Demirkiran C, Hartwich TMP, Bellone S, Manavella D, Mutlu L, Greenman M, Zipponi M, Yang-Hartwich Y, Yang K, Ratner E, Schwartz PE, Coma S, Pachter JA, Santin AD. McNamara B, et al. Among authors: pachter ja. Gynecol Oncol. 2024 Apr;183:133-140. doi: 10.1016/j.ygyno.2024.01.028. Epub 2024 Mar 15. Gynecol Oncol. 2024. PMID: 38493021
Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy.
Liu X, Baer JM, Stone ML, Knolhoff BL, Hogg GD, Turner MC, Kao YL, Weinstein AG, Ahmad F, Chen J, Schmidt AD, Klomp JA, Coho H, Coho KS, Coma S, Pachter JA, Bryant KL, Kang LI, Lim KH, Beatty GL, DeNardo DG. Liu X, et al. Among authors: pachter ja. Sci Transl Med. 2024 Oct 23;16(770):eado2402. doi: 10.1126/scitranslmed.ado2402. Epub 2024 Oct 23. Sci Transl Med. 2024. PMID: 39441902
Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy.
Blair AB, Wang J, Davelaar J, Baker A, Li K, Niu N, Wang J, Shao Y, Funes V, Li P, Pachter JA, Maneval DC, Dezem F, Plummer J, Chan KS, Gong J, Hendifar AE, Pandol SJ, Burkhart R, Zhang Y, Zheng L, Osipov A. Blair AB, et al. Among authors: pachter ja. Gastroenterology. 2022 Nov;163(5):1267-1280.e7. doi: 10.1053/j.gastro.2022.06.027. Epub 2022 Jun 17. Gastroenterology. 2022. PMID: 35718227 Free PMC article.
Early path dominance as a principle for neurodevelopment.
Razban RM, Pachter JA, Dill KA, Mujica-Parodi LR. Razban RM, et al. Among authors: pachter ja. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2218007120. doi: 10.1073/pnas.2218007120. Epub 2023 Apr 13. Proc Natl Acad Sci U S A. 2023. PMID: 37053187 Free PMC article.
Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis.
Ozmadenci D, Shankara Narayanan JS, Andrew J, Ojalill M, Barrie AM, Jiang S, Iyer S, Chen XL, Rose M, Estrada V, Molinolo A, Bertotto T, Mikulski Z, McHale MC, White RR, Connolly DC, Pachter JA, Kuchroo VK, Stupack DG, Schlaepfer DD. Ozmadenci D, et al. Among authors: pachter ja. Proc Natl Acad Sci U S A. 2022 Apr 26;119(17):e2117065119. doi: 10.1073/pnas.2117065119. Epub 2022 Apr 25. Proc Natl Acad Sci U S A. 2022. PMID: 35467979 Free PMC article.
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.
Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Gomes F, Arang N, Tiago M, Coma S, Lubrano S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS. Paradis JS, et al. Among authors: pachter ja. Clin Cancer Res. 2021 Jun 1;27(11):3190-3200. doi: 10.1158/1078-0432.CCR-20-3363. Epub 2021 Feb 10. Clin Cancer Res. 2021. PMID: 33568347 Free PMC article.
Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model.
Chen SS, Barrientos JC, Ferrer G, King-Richards M, Chen YJ, Ravichandran P, Ibrahim M, Kieso Y, Waters S, Kutok JL, Peluso M, Sharma S, Weaver DT, Pachter JA, Rai KR, Chiorazzi N. Chen SS, et al. Among authors: pachter ja. Clin Cancer Res. 2023 May 15;29(10):1984-1995. doi: 10.1158/1078-0432.CCR-22-2386. Clin Cancer Res. 2023. PMID: 37071496 Free PMC article.
78 results