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1962 2
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1989 5
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1996 2
1997 3
1998 5
1999 1
2000 3
2002 1
2003 1
2004 1
2006 3
2007 4
2009 1
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314 results

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Page 1
Strategies for the Syntheses of Pactamycin and Jogyamycin.
Gerstner NC, Nicastri KA, Schomaker JM. Gerstner NC, et al. Angew Chem Int Ed Engl. 2021 Jun 21;60(26):14252-14271. doi: 10.1002/anie.202004560. Epub 2021 Jan 18. Angew Chem Int Ed Engl. 2021. PMID: 32392399 Free PMC article. Review.
Pactamycin and jogyamycin are aminocyclopentitol natural products, where each core carbon bears a stereodefined alcohol or amine moiety. ...Interestingly, bioengineered analogues display differences in selectivity and toxicity towards mammalian cells, spurring efforts to d …
Pactamycin and jogyamycin are aminocyclopentitol natural products, where each core carbon bears a stereodefined alcohol or amine moie …
Pactamycin resistance mutations in functional sites of 16 S rRNA.
Mankin AS. Mankin AS. J Mol Biol. 1997 Nov 21;274(1):8-15. doi: 10.1006/jmbi.1997.1387. J Mol Biol. 1997. PMID: 9398510 Review.
Mutants of an archaeon Halobacterium halobium, resistant to the universal inhibitor of translation, pactamycin, were isolated. Pactamycin resistance correlated with the presence of mutations in the 16 S rRNA gene of H. halobium single rRNA operon. ...Pactamycin …
Mutants of an archaeon Halobacterium halobium, resistant to the universal inhibitor of translation, pactamycin, were isolated. Pac …
The secondary metabolite pactamycin with potential for pharmaceutical applications: biosynthesis and regulation.
Eida AA, Mahmud T. Eida AA, et al. Appl Microbiol Biotechnol. 2019 Jun;103(11):4337-4345. doi: 10.1007/s00253-019-09831-x. Epub 2019 Apr 25. Appl Microbiol Biotechnol. 2019. PMID: 31025074 Free PMC article. Review.
The antitumor antibiotic pactamycin is a highly substituted aminocyclopentitol-derived secondary metabolite produced by the soil bacterium Streptomyces pactum. ...However, a detailed understanding of its biosynthesis and how the biosynthesis is regulated has made it possib …
The antitumor antibiotic pactamycin is a highly substituted aminocyclopentitol-derived secondary metabolite produced by the soil bact …
Pactamycin.
WHITE FR. WHITE FR. Cancer Chemother Rep. 1962 Nov;24:75-8. Cancer Chemother Rep. 1962. PMID: 14000310 No abstract available.
Chemistry. Pactamycin made easy.
Codelli JA, Reisman SE. Codelli JA, et al. Science. 2013 Apr 12;340(6129):152-3. doi: 10.1126/science.1236882. Science. 2013. PMID: 23580517 No abstract available.
Pactamycin production by Streptomyces pactum.
BHUYAN BK. BHUYAN BK. Appl Microbiol. 1962 Jul;10(4):302-4. doi: 10.1128/am.10.4.302-304.1962. Appl Microbiol. 1962. PMID: 13868850 Free PMC article.
The optimal fermentation conditions for the production of pactamycin, a new antitumor antibiotic, by Streptomyces pactum var. pactum were investigated. ...Analysis of the biochemical changes during fermentation indicated that pactamycin was produced during the later …
The optimal fermentation conditions for the production of pactamycin, a new antitumor antibiotic, by Streptomyces pactum var. pactum …
Chemical Modification of Pactamycin Leads to New Compounds with Retained Antimicrobial Activity and Reduced Toxicity.
Tsirogianni A, Ntinou N, Karampatsou K, Dinos G, Kournoutou GG, Athanassopoulos CM. Tsirogianni A, et al. Molecules. 2024 Sep 3;29(17):4169. doi: 10.3390/molecules29174169. Molecules. 2024. PMID: 39275017 Free PMC article.
Pactamycin targets the small ribosomal subunit and inhibits protein synthesis in bacteria, archaea, and eukaryotes, but due to its toxicity is used only as a tool for biochemical research. Prompted by the successful and well-established procedure for the derivatization of …
Pactamycin targets the small ribosomal subunit and inhibits protein synthesis in bacteria, archaea, and eukaryotes, but due to its to …
Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues.
Ito T, Roongsawang N, Shirasaka N, Lu W, Flatt PM, Kasanah N, Miranda C, Mahmud T. Ito T, et al. Chembiochem. 2009 Sep 4;10(13):2253-65. doi: 10.1002/cbic.200900339. Chembiochem. 2009. PMID: 19670201
Pactamycin is an aminocyclopentitol-derived natural product that has potent antibacterial and antitumor activities. ...In vivo inactivation of ptmQ in S. pactum impaired pactamycin and pactamycate production but led to production of two new pactamycin analogu …
Pactamycin is an aminocyclopentitol-derived natural product that has potent antibacterial and antitumor activities. ...In vivo inacti …
Modifications of Acyl Carrier Protein-Bound Glycosylated Polyketides in Pactamycin Biosynthesis.
Eida AA, Samadi A, Tsunoda T, Mahmud T. Eida AA, et al. Chemistry. 2023 Jun 13;29(33):e202301056. doi: 10.1002/chem.202301056. Epub 2023 Apr 26. Chemistry. 2023. PMID: 37015882 Free PMC article.
The potent antitumor antibiotic pactamycin is an aminocyclopentitol-containing natural product produced by the soil bacterium Streptomyces pactum. ...
The potent antitumor antibiotic pactamycin is an aminocyclopentitol-containing natural product produced by the soil bacterium Strepto …
Synthetic Studies on Pactamycin: A Synthesis of Johnson's Intermediate.
Miura Y, Ouchi H, Inai M, Osawa T, Yoshimura F, Kanazawa J, Uchiyama M, Kondo M, Kan T. Miura Y, et al. Org Lett. 2020 May 1;22(9):3515-3518. doi: 10.1021/acs.orglett.0c00959. Epub 2020 Apr 22. Org Lett. 2020. PMID: 32319784
A formal total synthesis of pactamycin (1) has been accomplished by face-selective and regioselective nitroso Diels-Alder (NDA) reaction of acyl nitroso compound 14, which contains a camphorsultam chiral auxiliary, and chiral cyclopentadiene 12. ...
A formal total synthesis of pactamycin (1) has been accomplished by face-selective and regioselective nitroso Diels-Alder (NDA) react …
314 results