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Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Hurez V, et al. Among authors: padron a. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. Aging Cell. 2015. PMID: 26315673 Free PMC article.
Immunotherapy for ovarian cancer.
Drerup JM, Liu Y, Padron AS, Murthy K, Hurez V, Zhang B, Curiel TJ. Drerup JM, et al. Curr Treat Options Oncol. 2015 Jan;16(1):317. doi: 10.1007/s11864-014-0317-1. Curr Treat Options Oncol. 2015. PMID: 25648541 Free PMC article. Review.
Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.
Clark CA, Gupta HB, Sareddy G, Pandeswara S, Lao S, Yuan B, Drerup JM, Padron A, Conejo-Garcia J, Murthy K, Liu Y, Turk MJ, Thedieck K, Hurez V, Li R, Vadlamudi R, Curiel TJ. Clark CA, et al. Among authors: padron a. Cancer Res. 2016 Dec 1;76(23):6964-6974. doi: 10.1158/0008-5472.CAN-16-0258. Epub 2016 Sep 26. Cancer Res. 2016. PMID: 27671674 Free PMC article.
Considerations for successful cancer immunotherapy in aged hosts.
Hurez V, Padrón ÁS, Svatek RS, Curiel TJ. Hurez V, et al. Among authors: padron as. Clin Exp Immunol. 2017 Jan;187(1):53-63. doi: 10.1111/cei.12875. Epub 2016 Nov 7. Clin Exp Immunol. 2017. PMID: 27690272 Free PMC article. Review.
Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment.
Liu Y, Pandeswara S, Dao V, Padrón Á, Drerup JM, Lao S, Liu A, Hurez V, Curiel TJ. Liu Y, et al. Among authors: padron a. Cancer Res. 2017 Jan 15;77(2):520-531. doi: 10.1158/0008-5472.CAN-16-1140. Epub 2016 Oct 13. Cancer Res. 2017. PMID: 27737881 Free PMC article.
CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade.
Drerup JM, Deng Y, Pandeswara SL, Padrón ÁS, Reyes RM, Zhang X, Mendez J, Liu A, Clark CA, Chen W, Conejo-Garcia JR, Hurez V, Gupta H, Curiel TJ. Drerup JM, et al. Among authors: padron as. Cancer Res. 2020 Nov 15;80(22):5063-5075. doi: 10.1158/0008-5472.CAN-20-0002. Epub 2020 Sep 18. Cancer Res. 2020. PMID: 32948605 Free PMC article.
Bladder cancer cell-intrinsic PD-L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy.
Zhang D, Reyes RM, Osta E, Kari S, Gupta HB, Padron AS, Kornepati AVR, Kancharla A, Sun X, Deng Y, Wu B, Vadlamudi R, Li R, Svatek RS, Curiel TJ. Zhang D, et al. Among authors: padron as. Cancer Med. 2021 Mar;10(6):2137-2152. doi: 10.1002/cam4.3739. Epub 2021 Feb 24. Cancer Med. 2021. PMID: 33626233 Free PMC article.
87 results