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Year Number of Results
1966 1
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1982 1
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1986 2
1987 2
1988 2
1989 1
1991 3
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1993 2
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1998 3
1999 5
2000 4
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2005 14
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2007 20
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2009 21
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2011 14
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762 results

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Page 1
Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2alpha-Stat3 pathway in diabetic cardiomyopathy.
Liu C, Han Y, Gu X, Li M, Du Y, Feng N, Li J, Zhang S, Maslov LN, Wang G, Pei J, Fu F, Ding M. Liu C, et al. Redox Biol. 2021 Oct;46:102098. doi: 10.1016/j.redox.2021.102098. Epub 2021 Aug 10. Redox Biol. 2021. PMID: 34418601 Free PMC article.
This study aims to explore the effects of paeonol on mitochondrial disorderes in DCM and the underlying mechanisms. We showed that paeonol promoted Opa1-mediated mitochondrial fusion, inhibited mitochondrial oxidative stress, and preserved mitochondrial respiratory …
This study aims to explore the effects of paeonol on mitochondrial disorderes in DCM and the underlying mechanisms. We showed that …
Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway.
Li X, Shi H, Zhang D, Jing B, Chen Z, Zheng Y, Chang S, Gao L, Zhao G. Li X, et al. CNS Neurosci Ther. 2023 Sep;29(9):2666-2679. doi: 10.1111/cns.14211. Epub 2023 Apr 10. CNS Neurosci Ther. 2023. PMID: 37032648 Free PMC article.
The expression of iNOS, IL1beta, RhoA, and Rock1 was significantly increased in LPS-treated microglia, while paeonol decreased the expression of these proteins. Thermal hyperalgesia occurred after CCI surgery, and paeonol provided relief. ...Paeonol decreased …
The expression of iNOS, IL1beta, RhoA, and Rock1 was significantly increased in LPS-treated microglia, while paeonol decreased the ex …
Paeonol: pharmacological effects and mechanisms of action.
Zhang L, Li DC, Liu LF. Zhang L, et al. Int Immunopharmacol. 2019 Jul;72:413-421. doi: 10.1016/j.intimp.2019.04.033. Epub 2019 Apr 25. Int Immunopharmacol. 2019. PMID: 31030097 Review.
Paeonol injection has been successfully applied in China for nearly 50 years for inflammation/pain-related indications. ...So far, the clinical applications of paeonol are mainly focusing on the anti-inflammatory activity. Studies of other pharmacological activities …
Paeonol injection has been successfully applied in China for nearly 50 years for inflammation/pain-related indications. ...So far, th …
Paeonol Derivatives and Pharmacological Activities: A Review of Recent Progress.
Wang J, Wu G, Chu H, Wu Z, Sun J. Wang J, et al. Mini Rev Med Chem. 2020;20(6):466-482. doi: 10.2174/1389557519666191015204223. Mini Rev Med Chem. 2020. PMID: 31644406 Review.
Modern medical research has shown that paeonol has a wide range of pharmacological activities. In recent years, a large number of studies have been carried out on the structure modification of paeonol and the mechanism of action of paeonol derivatives has bee …
Modern medical research has shown that paeonol has a wide range of pharmacological activities. In recent years, a large number of stu …
Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKCepsilon-Stat3 pathway.
Ding M, Shi R, Fu F, Li M, De D, Du Y, Li Z. Ding M, et al. J Adv Res. 2023 May;47:151-162. doi: 10.1016/j.jare.2022.07.002. Epub 2022 Jul 14. J Adv Res. 2023. PMID: 35842187 Free PMC article.
OBJECTIVES: The objective of this study was to determine whether Paeonol (Pae) has the ability to protect against Dox-induced cardiotoxicity and if so, what are the underlying mechanisms involved. ...
OBJECTIVES: The objective of this study was to determine whether Paeonol (Pae) has the ability to protect against Dox-induced cardiot …
Paeonol repurposing for cancer therapy: From mechanism to clinical translation.
Wang Y, Li BS, Zhang ZH, Wang Z, Wan YT, Wu FW, Liu JC, Peng JX, Wang HY, Hong L. Wang Y, et al. Biomed Pharmacother. 2023 Sep;165:115277. doi: 10.1016/j.biopha.2023.115277. Epub 2023 Aug 4. Biomed Pharmacother. 2023. PMID: 37544285 Free article. Review.
Paeonol (PAE) is a natural phenolic monomer isolated from the root bark of Paeonia suffruticosa that has been widely used in the clinical treatment of some inflammatory-related diseases and cardiovascular diseases. ...
Paeonol (PAE) is a natural phenolic monomer isolated from the root bark of Paeonia suffruticosa that has been widely used in the clin …
Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview.
Wu M, Yu Z, Li X, Zhang X, Wang S, Yang S, Hu L, Liu L. Wu M, et al. Front Cardiovasc Med. 2021 Jul 21;8:690116. doi: 10.3389/fcvm.2021.690116. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34368250 Free PMC article. Review.
However, comprehensive reviews on the cardiovascular protective effects of paeonol have not been conducted. The current review summarizes studies reporting on the protective effects of paeonol on the cardiovascular system. ...Further studies should be conducted to e …
However, comprehensive reviews on the cardiovascular protective effects of paeonol have not been conducted. The current review summar …
Biological Activities of Paeonol in Cardiovascular Diseases: A Review.
Vellasamy S, Murugan D, Abas R, Alias A, Seng WY, Woon CK. Vellasamy S, et al. Molecules. 2021 Aug 17;26(16):4976. doi: 10.3390/molecules26164976. Molecules. 2021. PMID: 34443563 Free PMC article. Review.
Paeonol is a naturally existing bioactive compound found in the root bark of Paeonia suffruticosa and it is traditionally used in Chinese medicine for the prevention and management of cardiovascular diseases. To date, a great deal of studies has been reported on the pharma …
Paeonol is a naturally existing bioactive compound found in the root bark of Paeonia suffruticosa and it is traditionally used in Chi …
Protective mechanism of Paeonol on central nervous system.
Wu R, Liu Y, Zhang F, Dai S, Xue X, Peng C, Li Y, Li Y. Wu R, et al. Phytother Res. 2024 Feb;38(2):470-488. doi: 10.1002/ptr.8049. Epub 2023 Oct 23. Phytother Res. 2024. PMID: 37872838 Review.
The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical synthetic medicines. Paeonol is the main active component of traditional Chinese medicine Paeonia lactiflora Pall. It widely exists i …
The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical …
A review on therapeutical potential of paeonol in atherosclerosis.
Yu W, Ilyas I, Aktar N, Xu S. Yu W, et al. Front Pharmacol. 2022 Aug 4;13:950337. doi: 10.3389/fphar.2022.950337. eCollection 2022. Front Pharmacol. 2022. PMID: 35991897 Free PMC article. Review.
The pleiotropic effects of paeonol in atherosclerosis suggest that it can be a promising therapeutic agent for atherosclerosis and its complications. Large-scale randomized clinical trials are warranted to elucidate whether paeonol are effective in patients with ASC …
The pleiotropic effects of paeonol in atherosclerosis suggest that it can be a promising therapeutic agent for atherosclerosis and it …
762 results