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101 results
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Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.
Paine MF, Oberlies NH. Paine MF, et al. Expert Opin Drug Metab Toxicol. 2007 Feb;3(1):67-80. doi: 10.1517/17425255.3.1.67. Expert Opin Drug Metab Toxicol. 2007. PMID: 17269895 Review.
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.
Thummel KE, O'Shea D, Paine MF, Shen DD, Kunze KL, Perkins JD, Wilkinson GR. Thummel KE, et al. Among authors: paine mf. Clin Pharmacol Ther. 1996 May;59(5):491-502. doi: 10.1016/S0009-9236(96)90177-0. Clin Pharmacol Ther. 1996. PMID: 8646820 Clinical Trial.
Immunochemical identification of UGT isoforms in human small bowel and in caco-2 cell monolayers.
Paine MF, Fisher MB. Paine MF, et al. Biochem Biophys Res Commun. 2000 Jul 14;273(3):1053-7. doi: 10.1006/bbrc.2000.3064. Biochem Biophys Res Commun. 2000. PMID: 10891370
Can oral midazolam predict oral cyclosporine disposition?
Paine MF, Davis CL, Shen DD, Marsh CL, Raisys VA, Thummel KE. Paine MF, et al. Eur J Pharm Sci. 2000 Nov;12(1):51-62. doi: 10.1016/s0928-0987(00)00139-1. Eur J Pharm Sci. 2000. PMID: 11121733
Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion.
Paine MF, Leung LY, Lim HK, Liao K, Oganesian A, Zhang MY, Thummel KE, Watkins PB. Paine MF, et al. J Pharmacol Exp Ther. 2002 Apr;301(1):174-86. doi: 10.1124/jpet.301.1.174. J Pharmacol Exp Ther. 2002. PMID: 11907172
Contributions of CYP3A4, P-glycoprotein, and serum protein binding to the intestinal first-pass extraction of saquinavir.
Mouly SJ, Paine MF, Watkins PB. Mouly SJ, et al. Among authors: paine mf. J Pharmacol Exp Ther. 2004 Mar;308(3):941-8. doi: 10.1124/jpet.103.056390. Epub 2004 Jan 8. J Pharmacol Exp Ther. 2004. PMID: 14718607
Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties.
Paine MF, Criss AB, Watkins PB. Paine MF, et al. Drug Metab Dispos. 2004 Oct;32(10):1146-53. doi: 10.1124/dmd.104.000547. Epub 2004 Jul 21. Drug Metab Dispos. 2004. PMID: 15269184
New insights into drug absorption: studies with sirolimus.
Paine MF, Leung LY, Watkins PB. Paine MF, et al. Ther Drug Monit. 2004 Oct;26(5):463-7. doi: 10.1097/00007691-200410000-00001. Ther Drug Monit. 2004. PMID: 15385826 Review.
Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition.
Paine MF, Criss AB, Watkins PB. Paine MF, et al. J Pharmacol Exp Ther. 2005 Mar;312(3):1151-60. doi: 10.1124/jpet.104.076836. Epub 2004 Oct 14. J Pharmacol Exp Ther. 2005. PMID: 15485894
Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?
Paine MF, Ludington SS, Chen ML, Stewart PW, Huang SM, Watkins PB. Paine MF, et al. Drug Metab Dispos. 2005 Mar;33(3):426-33. doi: 10.1124/dmd.104.002469. Epub 2004 Dec 17. Drug Metab Dispos. 2005. PMID: 15608139
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