Paine SW - Search Results

1

In silico human and rat Vss quantitative structure-activity relationship models.

Gleeson MP, Waters NJ, Paine SW, Davis AM. Gleeson MP, et al. Among authors: paine sw. J Med Chem. 2006 Mar 23;49(6):1953-63. doi: 10.1021/jm0510070. J Med Chem. 2006. PMID: 16539383

2

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action.

Stocks MJ, Alcaraz L, Bailey A, Bonnert R, Cadogan E, Christie J, Dixon J, Connolly S, Cook A, Fisher A, Flaherty A, Humphries A, Ingall A, Jordan S, Lawson M, Mullen A, Nicholls D, Paine S, Pairaudeau G, Young A. Stocks MJ, et al. ACS Med Chem Lett. 2014 Feb 8;5(4):416-21. doi: 10.1021/ml4005232. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900851 Free PMC article.

3

From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.

Alcaraz L, Bailey A, Cadogan E, Connolly S, Jewell R, Jordan S, Kindon N, Lister A, Lawson M, Mullen A, Dainty I, Nicholls D, Paine S, Pairaudeau G, Stocks MJ, Thorne P, Young A. Alcaraz L, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):689-95. doi: 10.1016/j.bmcl.2011.10.049. Epub 2011 Oct 20. Bioorg Med Chem Lett. 2012. PMID: 22079756

4

In silico prediction of acyl glucuronide reactivity.

Potter T, Lewis R, Luker T, Bonnert R, Bernstein MA, Birkinshaw TN, Thom S, Wenlock M, Paine S. Potter T, et al. J Comput Aided Mol Des. 2011 Nov;25(11):997-1005. doi: 10.1007/s10822-011-9479-0. Epub 2011 Oct 26. J Comput Aided Mol Des. 2011. PMID: 22042375

5

Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.

Luker T, Bonnert R, Brough S, Cook AR, Dickinson MR, Dougall I, Logan C, Mohammed RT, Paine S, Sanganee HJ, Sargent C, Schmidt JA, Teague S, Thom S. Luker T, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6288-92. doi: 10.1016/j.bmcl.2011.08.124. Epub 2011 Sep 5. Bioorg Med Chem Lett. 2011. PMID: 21944852

6

Design-driven LO: the discovery of new ultra long acting dibasic β2-adrenoceptor agonists.

Connolly S, Alcaraz L, Bailey A, Cadogan E, Christie J, Cook AR, Fisher AJ, Hill S, Humphries A, Ingall AH, Kane Z, Paine S, Pairaudeau G, Stocks MJ, Young A. Connolly S, et al. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4612-6. doi: 10.1016/j.bmcl.2011.05.097. Epub 2011 Jun 13. Bioorg Med Chem Lett. 2011. PMID: 21723724

7

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors.

Baxter A, Brough S, Cooper A, Floettmann E, Foster S, Harding C, Kettle J, McInally T, Martin C, Mobbs M, Needham M, Newham P, Paine S, St-Gallay S, Salter S, Unitt J, Xue Y. Baxter A, et al. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22. doi: 10.1016/j.bmcl.2004.03.058. Bioorg Med Chem Lett. 2004. PMID: 15125939

8

Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists.

Stocks MJ, Alcaraz L, Bailey A, Bonnert R, Cadogan E, Christie J, Connolly S, Cook A, Fisher A, Flaherty A, Hill S, Humphries A, Ingall A, Jordan S, Lawson M, Mullen A, Nicholls D, Paine S, Pairaudeau G, St-Gallay S, Young A. Stocks MJ, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4027-31. doi: 10.1016/j.bmcl.2011.04.135. Epub 2011 May 20. Bioorg Med Chem Lett. 2011. PMID: 21652207

9

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.

Luker T, Bonnert R, Schmidt J, Sargent C, Paine SW, Thom S, Pairaudeau G, Patel A, Mohammed R, Akam E, Dougall I, Davis AM, Abbott P, Brough S, Millichip I, McInally T. Luker T, et al. Among authors: paine sw. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3616-21. doi: 10.1016/j.bmcl.2011.04.101. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21592791

10

Zwitterionic CRTh2 antagonists.

Luker T, Bonnert R, Paine SW, Schmidt J, Sargent C, Cook AR, Cook A, Gardiner P, Hill S, Weyman-Jones C, Patel A, Thom S, Thorne P. Luker T, et al. Among authors: paine sw. J Med Chem. 2011 Mar 24;54(6):1779-88. doi: 10.1021/jm1014549. Epub 2011 Feb 28. J Med Chem. 2011. PMID: 21355602

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

Search Page

Search Results