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T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.
Tringham E, Powell KL, Cain SM, Kuplast K, Mezeyova J, Weerapura M, Eduljee C, Jiang X, Smith P, Morrison JL, Jones NC, Braine E, Rind G, Fee-Maki M, Parker D, Pajouhesh H, Parmar M, O'Brien TJ, Snutch TP. Tringham E, et al. Among authors: pajouhesh h. Sci Transl Med. 2012 Feb 15;4(121):121ra19. doi: 10.1126/scitranslmed.3003120. Sci Transl Med. 2012. PMID: 22344687 Free article.
Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.
Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch TP. Pajouhesh H, et al. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1378-83. doi: 10.1016/j.bmcl.2010.01.008. Epub 2010 Jan 7. Bioorg Med Chem Lett. 2010. PMID: 20117000
Scaffold-based design and synthesis of potent N-type calcium channel blockers.
Zamponi GW, Feng ZP, Zhang L, Pajouhesh H, Ding Y, Belardetti F, Pajouhesh H, Dolphin D, Mitscher LA, Snutch TP. Zamponi GW, et al. Among authors: pajouhesh h. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. doi: 10.1016/j.bmcl.2009.09.008. Epub 2009 Sep 11. Bioorg Med Chem Lett. 2009. PMID: 19815411
A novel slow-inactivation-specific ion channel modulator attenuates neuropathic pain.
Hildebrand ME, Smith PL, Bladen C, Eduljee C, Xie JY, Chen L, Fee-Maki M, Doering CJ, Mezeyova J, Zhu Y, Belardetti F, Pajouhesh H, Parker D, Arneric SP, Parmar M, Porreca F, Tringham E, Zamponi GW, Snutch TP. Hildebrand ME, et al. Among authors: pajouhesh h. Pain. 2011 Apr;152(4):833-843. doi: 10.1016/j.pain.2010.12.035. Epub 2011 Feb 23. Pain. 2011. PMID: 21349638
A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Johansen LM, DeWald LE, Shoemaker CJ, Hoffstrom BG, Lear-Rooney CM, Stossel A, Nelson E, Delos SE, Simmons JA, Grenier JM, Pierce LT, Pajouhesh H, Lehár J, Hensley LE, Glass PJ, White JM, Olinger GG. Johansen LM, et al. Among authors: pajouhesh h. Sci Transl Med. 2015 Jun 3;7(290):290ra89. doi: 10.1126/scitranslmed.aaa5597. Sci Transl Med. 2015. PMID: 26041706
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