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Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.
Fernández S, Wasowski C, Paladini AC, Marder M. Fernández S, et al. Among authors: paladini ac. Pharmacol Biochem Behav. 2004 Feb;77(2):399-404. doi: 10.1016/j.pbb.2003.12.003. Pharmacol Biochem Behav. 2004. PMID: 14751470
Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice.
Martínez MC, Fernandez SP, Loscalzo LM, Wasowski C, Paladini AC, Marder M, Medina JH, Viola H. Martínez MC, et al. Among authors: paladini ac. Pharmacol Biochem Behav. 2009 Apr;92(2):291-6. doi: 10.1016/j.pbb.2008.12.016. Epub 2008 Dec 31. Pharmacol Biochem Behav. 2009. PMID: 19159642
Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines.
Loscalzo LM, Wasowski C, Paladini AC, Marder M. Loscalzo LM, et al. Among authors: paladini ac. Eur J Pharmacol. 2008 Feb 12;580(3):306-13. doi: 10.1016/j.ejphar.2007.11.011. Epub 2007 Nov 13. Eur J Pharmacol. 2008. PMID: 18048026
Central nervous system depressant action of flavonoid glycosides.
Fernández SP, Wasowski C, Loscalzo LM, Granger RE, Johnston GA, Paladini AC, Marder M. Fernández SP, et al. Among authors: paladini ac. Eur J Pharmacol. 2006 Jun 13;539(3):168-76. doi: 10.1016/j.ejphar.2006.04.004. Epub 2006 Apr 6. Eur J Pharmacol. 2006. PMID: 16698011
Synergistic interaction between hesperidin, a natural flavonoid, and diazepam.
Fernández SP, Wasowski C, Paladini AC, Marder M. Fernández SP, et al. Among authors: paladini ac. Eur J Pharmacol. 2005 Apr 11;512(2-3):189-98. doi: 10.1016/j.ejphar.2005.02.039. Eur J Pharmacol. 2005. PMID: 15840404
GABA(A)-receptor ligands of flavonoid structure.
Marder M, Paladini AC. Marder M, et al. Among authors: paladini ac. Curr Top Med Chem. 2002 Aug;2(8):853-67. doi: 10.2174/1568026023393462. Curr Top Med Chem. 2002. PMID: 12171576 Review.
6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS.
Marder M, Viola H, Wasowski C, Fernández S, Medina JH, Paladini AC. Marder M, et al. Among authors: paladini ac. Pharmacol Biochem Behav. 2003 Jun;75(3):537-45. doi: 10.1016/s0091-3057(03)00121-7. Pharmacol Biochem Behav. 2003. PMID: 12895671
Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichii.
Wasowski C, Marder M, Viola H, Medina JH, Paladini AC. Wasowski C, et al. Among authors: paladini ac. Planta Med. 2002 Oct;68(10):934-6. doi: 10.1055/s-2002-34936. Planta Med. 2002. PMID: 12391561
6-Bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids.
Marder M, Viola H, Wasowski C, Wolfman C, Waterman PG, Cassels BK, Medina JG, Paladini AC. Marder M, et al. Among authors: paladini ac. Biochem Biophys Res Commun. 1996 Jun 14;223(2):384-9. doi: 10.1006/bbrc.1996.0903. Biochem Biophys Res Commun. 1996. PMID: 8670291
In vivo formation of benzodiazepine-like molecules in mammalian brain.
Medina JH, Levi de Stein M, Wolfman C, Wasowski C, De Blas A, Paladini AC. Medina JH, et al. Among authors: paladini ac. Biochem Biophys Res Commun. 1993 Sep 15;195(2):1111-8. doi: 10.1006/bbrc.1993.2159. Biochem Biophys Res Commun. 1993. PMID: 8396918
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