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Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.
Tzoneva G, Perez-Garcia A, Carpenter Z, Khiabanian H, Tosello V, Allegretta M, Paietta E, Racevskis J, Rowe JM, Tallman MS, Paganin M, Basso G, Hof J, Kirschner-Schwabe R, Palomero T, Rabadan R, Ferrando A. Tzoneva G, et al. Among authors: palomero t. Nat Med. 2013 Mar;19(3):368-71. doi: 10.1038/nm.3078. Epub 2013 Feb 3. Nat Med. 2013. PMID: 23377281 Free PMC article.
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, Aster JC, Sigaux F, Soulier J, Look AT, Young RA, Califano A, Ferrando AA. Palomero T, et al. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18261-6. doi: 10.1073/pnas.0606108103. Epub 2006 Nov 17. Proc Natl Acad Sci U S A. 2006. PMID: 17114293 Free PMC article.
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I. Vilimas T, et al. Among authors: palomero t. Nat Med. 2007 Jan;13(1):70-7. doi: 10.1038/nm1524. Epub 2006 Dec 17. Nat Med. 2007. PMID: 17173050
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA. Palomero T, et al. Nat Med. 2007 Oct;13(10):1203-10. doi: 10.1038/nm1636. Epub 2007 Sep 16. Nat Med. 2007. PMID: 17873882 Free PMC article.
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