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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.
Wu S, Huang J, Dong J, Pan D. Wu S, et al. Among authors: pan d. Cell. 2003 Aug 22;114(4):445-56. doi: 10.1016/s0092-8674(03)00549-x. Cell. 2003. PMID: 12941273
Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex.
Zheng Y, Liu B, Wang L, Lei H, Pulgar Prieto KD, Pan D. Zheng Y, et al. Among authors: pan d. Cell Rep. 2017 Dec 19;21(12):3612-3623. doi: 10.1016/j.celrep.2017.11.076. Cell Rep. 2017. PMID: 29262338 Free PMC article.
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.
Huang J, Wu S, Barrera J, Matthews K, Pan D. Huang J, et al. Among authors: pan d. Cell. 2005 Aug 12;122(3):421-34. doi: 10.1016/j.cell.2005.06.007. Cell. 2005. PMID: 16096061
Tsc2 is not a critical target of Akt during normal Drosophila development.
Dong J, Pan D. Dong J, et al. Among authors: pan d. Genes Dev. 2004 Oct 15;18(20):2479-84. doi: 10.1101/gad.1240504. Epub 2004 Oct 1. Genes Dev. 2004. PMID: 15466161 Free PMC article.
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D. Zhang Y, et al. Among authors: pan d. Nat Cell Biol. 2003 Jun;5(6):578-81. doi: 10.1038/ncb999. Nat Cell Biol. 2003. PMID: 12771962
NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart.
Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, Sadoshima J, Del Re DP. Matsuda T, et al. Among authors: pan d. Circ Res. 2016 Aug 19;119(5):596-606. doi: 10.1161/CIRCRESAHA.116.308586. Epub 2016 Jul 11. Circ Res. 2016. PMID: 27402866 Free PMC article.
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation.
Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. Yu FX, et al. Among authors: pan d. Genes Dev. 2013 Jun 1;27(11):1223-32. doi: 10.1101/gad.219402.113. Genes Dev. 2013. PMID: 23752589 Free PMC article.
The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.
Koontz LM, Liu-Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, Chen Q, Wu S, Pan D. Koontz LM, et al. Among authors: pan d. Dev Cell. 2013 May 28;25(4):388-401. doi: 10.1016/j.devcel.2013.04.021. Dev Cell. 2013. PMID: 23725764 Free PMC article.
Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.
Chan P, Han X, Zheng B, DeRan M, Yu J, Jarugumilli GK, Deng H, Pan D, Luo X, Wu X. Chan P, et al. Among authors: pan d. Nat Chem Biol. 2016 Apr;12(4):282-9. doi: 10.1038/nchembio.2036. Epub 2016 Feb 22. Nat Chem Biol. 2016. PMID: 26900866 Free PMC article.
The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.
Wu S, Liu Y, Zheng Y, Dong J, Pan D. Wu S, et al. Among authors: pan d. Dev Cell. 2008 Mar;14(3):388-98. doi: 10.1016/j.devcel.2008.01.007. Epub 2008 Feb 7. Dev Cell. 2008. PMID: 18258486
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