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Page 1
PDX-derived organoids model in vivo drug response and secrete biomarkers.
Huang L, Bockorny B, Paul I, Akshinthala D, Frappart PO, Gandarilla O, Bose A, Sanchez-Gonzalez V, Rouse EE, Lehoux SD, Pandell N, Lim CM, Clohessy JG, Grossman J, Gonzalez R, Del Pino SP, Daaboul G, Sawhney MS, Freedman SD, Kleger A, Cummings RD, Emili A, Muthuswamy LB, Hidalgo M, Muthuswamy SK. Huang L, et al. Among authors: pandell n. JCI Insight. 2020 Nov 5;5(21):e135544. doi: 10.1172/jci.insight.135544. JCI Insight. 2020. PMID: 32990680 Free PMC article.
Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.
Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, Pandell N, Avagyan S, Brogie JE, van Rooijen E, Hagedorn EJ, Shyh-Chang N, White RM, Price DH, Pandolfi PP, Peterlin BM, Zhou Y, Kim TH, Asara JM, Chang HY, Young RA, Zon LI. Tan JL, et al. Among authors: pandell n. Mol Cell. 2016 Apr 7;62(1):34-46. doi: 10.1016/j.molcel.2016.03.013. Mol Cell. 2016. PMID: 27058786 Free PMC article.
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer.
Maroni G, Bassal MA, Krishnan I, Fhu CW, Savova V, Zilionis R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Storti B, Castaño J, Panella R, Li J, Gustafson CE, Fox S, Levy RD, Meyerovitz CV, Tramontozzi PJ, Vermilya K, De Rienzo A, Crucitta S, Bassères DS, Weetall M, Branstrom A, Giorgetti A, Ciampi R, Del Re M, Danesi R, Bizzarri R, Yang H, Kocher O, Klein AM, Welner RS, Bueno R, Magli MC, Clohessy JG, Ali A, Tenen DG, Levantini E. Maroni G, et al. Among authors: pandell n. Commun Biol. 2021 Apr 14;4(1):370. doi: 10.1038/s42003-021-01897-6. Commun Biol. 2021. PMID: 33854168 Free PMC article.
Developing therapeutic strategies to target MCL1 and BCLXL in lethal prostate cancer.
Westaby D, Jiménez-Vacas JM, Figueiredo I, Welti J, Gurel B, Bogdan D, Buroni L, Neeb AJ, Rekowski J, Padilha A, Das S, Taylor J, Zeng W, Waldron N, Goldsmith T, Hobern E, Gabel F, Pandell N, Miranda S, Lambros MB, Carreira S, Swain A, Yuan W, Balk SP, Bezzi M, de Bono JS, Sharp A. Westaby D, et al. Among authors: pandell n. iScience. 2025 Nov 10;28(12):113985. doi: 10.1016/j.isci.2025.113985. eCollection 2025 Dec 19. iScience. 2025. PMID: 41438049 Free PMC article.
Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.
Jiménez-Vacas JM, Westaby D, Figueiredo I, De Haven Brandon A, Padilha A, Yuan W, Seed G, Bogdan D, Gurel B, Bertan C, Miranda S, Lambros M, Montero-Hidalgo AJ, Coleman I, Yu IPL, Buroni L, Zeng W, Neeb AJ, Welti J, Rekowski J, Paravati R, Gabel F, Pandell N, Ferreira A, Crespo M, Riisnaes R, Das S, Taylor J, Waldron N, Hobern E, Valenti M, Ning J, Bernett I, Liodaki K, Persse T, Galipeau P, Wilkinson S, Trostel SY, Karzai F, Chau CH, Beatson EL, Zhang X, Klumpp-Thomas C, Varkaris A, Luque RM, Swain A, Raynaud F, Lack NA, Thomas CJ, Ha G, Figg WD, Bezzi M, Sowalsky AG, Nelson PS, Carreira S, Balk SP, de Bono JS, Sharp A. Jiménez-Vacas JM, et al. Among authors: pandell n. Nat Commun. 2025 Oct 8;16(1):8806. doi: 10.1038/s41467-025-64042-5. Nat Commun. 2025. PMID: 41062500 Free PMC article.
Correction: Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment.
Maroni G, Krishnan I, Alfieri R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Weetall M, Branstrom A, Braccini G, San Millán EC, Storti B, Bizzarri R, Kocher O, Bassères DS, Welner RS, Magli MC, Merelli I, Clohessy JG, Ali A, Tenen DG, Levantini E. Maroni G, et al. Among authors: pandell n. Cancer Res Commun. 2025 Apr 1;5(4):647. doi: 10.1158/2767-9764.CRC-25-0200. Cancer Res Commun. 2025. PMID: 40249007 Free PMC article. No abstract available.
Tumor Microenvironment Landscapes Supporting EGFR-mutant NSCLC Are Modulated at the Single-cell Interaction Level by Unesbulin Treatment.
Maroni G, Krishnan I, Alfieri R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Weetall M, Branstrom A, Braccini G, Cabrera San Millán E, Storti B, Bizzarri R, Kocher O, Daniela Sanchez Bassères DS, Welner RS, Magli MC, Merelli I, Clohessy JG, Ali A, Tenen DG, Levantini E. Maroni G, et al. Among authors: pandell n. Cancer Res Commun. 2024 Mar 26;4(3):919-937. doi: 10.1158/2767-9764.CRC-23-0161. Cancer Res Commun. 2024. PMID: 38546390 Free PMC article.