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Membrane-anchored growth factors.
Massagué J, Pandiella A. Massagué J, et al. Among authors: pandiella a. Annu Rev Biochem. 1993;62:515-41. doi: 10.1146/annurev.bi.62.070193.002503. Annu Rev Biochem. 1993. PMID: 8394682 Review. No abstract available.
Autocrine regulation of membrane transforming growth factor-alpha cleavage.
Baselga J, Mendelsohn J, Kim YM, Pandiella A. Baselga J, et al. Among authors: pandiella a. J Biol Chem. 1996 Feb 9;271(6):3279-84. doi: 10.1074/jbc.271.6.3279. J Biol Chem. 1996. PMID: 8621731
Transforming growth factor alpha (TGF-alpha) is biosynthesized as a membrane-bound precursor protein, pro-TGF-alpha, that undergoes sequential endoproteolytic cleavages to release a soluble form of the factor. ...Activation of the EGF receptor by soluble EGF or TGF- …
Transforming growth factor alpha (TGF-alpha) is biosynthesized as a membrane-bound precursor protein, pro-TGF-alpha, that undergoes s …
Activated release of membrane-anchored TGF-alpha in the absence of cytosol.
Bosenberg MW, Pandiella A, Massagué J. Bosenberg MW, et al. Among authors: pandiella a. J Cell Biol. 1993 Jul;122(1):95-101. doi: 10.1083/jcb.122.1.95. J Cell Biol. 1993. PMID: 8314849 Free PMC article.
The ectodomain of proTGF-alpha, a membrane-anchored growth factor, is converted into soluble TGF-alpha by a regulated cellular proteolytic system that recognizes proTGF-alpha via the C-terminal valine of its cytoplasmic tail. ...ProTGF-alpha cleavage is also stimula …
The ectodomain of proTGF-alpha, a membrane-anchored growth factor, is converted into soluble TGF-alpha by a regulated cellular …
Multiple signals activate cleavage of the membrane transforming growth factor-alpha precursor.
Pandiella A, Massagué J. Pandiella A, et al. J Biol Chem. 1991 Mar 25;266(9):5769-73. J Biol Chem. 1991. PMID: 2005114
Cleavage of the membrane-anchored precursor for transforming growth factor-alpha (TGF-alpha), a rate-limiting step in the generation of soluble TGF-alpha, can be stimulated by phorbol esters acting via protein kinase C. ...These results suggest that regulation of pro-TGF-a …
Cleavage of the membrane-anchored precursor for transforming growth factor-alpha (TGF-alpha), a rate-limiting step in the generation …
Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.
Pandiella A, Massagué J. Pandiella A, et al. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1726-30. doi: 10.1073/pnas.88.5.1726. Proc Natl Acad Sci U S A. 1991. PMID: 2000380 Free PMC article.
Transforming growth factor alpha (TGF-alpha) is generated by cleavage of a membrane-anchored precursor protein, proTGF-alpha. ...The results demonstrate the existence of mechanisms that control the switch of TGF-alpha from a juxtacrine to a paracrine growth f …
Transforming growth factor alpha (TGF-alpha) is generated by cleavage of a membrane-anchored precursor protein, proTGF-alpha. ...The …
Transforming growth factor-alpha.
Pandiella A, Massague J. Pandiella A, et al. Biochem Soc Trans. 1991 Apr;19(2):259-62. doi: 10.1042/bst0190259. Biochem Soc Trans. 1991. PMID: 1889609 Review. No abstract available.
Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms.
Pandiella A, Bosenberg MW, Huang EJ, Besmer P, Massagué J. Pandiella A, et al. J Biol Chem. 1992 Nov 25;267(33):24028-33. J Biol Chem. 1992. PMID: 1385433
Each of these proteins is cleaved at a distinct site, however their cleavage is activated via a common set of intracellular signaling mechanisms. ...It is concluded that cleavage of membrane-anchored growth factors involves a proteolytic system with multiple …
Each of these proteins is cleaved at a distinct site, however their cleavage is activated via a common set of intracellular si …
The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factor.
Bosenberg MW, Pandiella A, Massagué J. Bosenberg MW, et al. Among authors: pandiella a. Cell. 1992 Dec 24;71(7):1157-65. doi: 10.1016/s0092-8674(05)80064-9. Cell. 1992. PMID: 1473151
Membrane-anchored transforming growth factor alpha (proTGF alpha) belongs to a group of transmembrane proteins whose extracellular domains are selectively cleaved and released into the medium. ...We propose that cleavage and release of proTGF alpha ectodomain involve a
Membrane-anchored transforming growth factor alpha (proTGF alpha) belongs to a group of transmembrane proteins whose extracellular do …
Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies.
Baselga J, Norton L, Masui H, Pandiella A, Coplan K, Miller WH Jr, Mendelsohn J. Baselga J, et al. Among authors: pandiella a. J Natl Cancer Inst. 1993 Aug 18;85(16):1327-33. doi: 10.1093/jnci/85.16.1327. J Natl Cancer Inst. 1993. PMID: 8340945
BACKGROUND: A variety of human tumors frequently express high levels of epidermal growth factor (EGF) receptor and its ligand, transforming growth factor alpha (TGF-alpha), which in some tumors is associated with poor prognosis. ...In nude mice, doxorubicin was given at do …
BACKGROUND: A variety of human tumors frequently express high levels of epidermal growth factor (EGF) receptor and its ligand, transf …
Reinforcement of signal generation at B2 bradykinin receptors by insulin, epidermal growth factors, and other growth factors.
Pandiella A, Meldolesi J. Pandiella A, et al. J Biol Chem. 1989 Feb 25;264(6):3122-30. J Biol Chem. 1989. PMID: 2536735
The latter peptide, working through a B2 receptor, caused hydrolysis of polyphosphoinositides and a large, biphasic [Ca2+]i transient (an initial (1-2 min) spike, originated primarily from intracellular stores, followed by a steady-state elevation dependent o …
The latter peptide, working through a B2 receptor, caused hydrolysis of polyphosphoinositides and a large, biphasic [Ca2+]i tr …
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