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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. Vaziri H, et al. Cell. 2001 Oct 19;107(2):149-59. doi: 10.1016/s0092-8674(01)00527-x. Cell. 2001. PMID: 11672523
The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.
Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J. Jacquet K, et al. Mol Cell. 2016 May 5;62(3):409-421. doi: 10.1016/j.molcel.2016.03.031. Mol Cell. 2016. PMID: 27153538 Free PMC article.
Lack of PTEN sequesters CHK1 and initiates genetic instability.
Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, Piwnica-Worms H, Hibshoosh H, Parsons R. Puc J, et al. Cancer Cell. 2005 Feb;7(2):193-204. doi: 10.1016/j.ccr.2005.01.009. Cancer Cell. 2005. PMID: 15710331
Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase.
Kharbanda S, Kumar V, Dhar S, Pandey P, Chen C, Majumder P, Yuan ZM, Whang Y, Strauss W, Pandita TK, Weaver D, Kufe D. Kharbanda S, et al. Curr Biol. 2000 May 18;10(10):568-75. doi: 10.1016/s0960-9822(00)00483-8. Curr Biol. 2000. PMID: 10837221
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Gupta A, Hunt CR, Hegde ML, Chakraborty S, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK. Gupta A, et al. Cell Rep. 2014 Jul 10;8(1):177-89. doi: 10.1016/j.celrep.2014.05.044. Epub 2014 Jun 19. Cell Rep. 2014. PMID: 24953651 Free PMC article.
Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts.
Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, Zhang H, Gulyas S, Hill RP, Nolan GP, Benchimol S. Vaziri H, et al. Mol Cell Biol. 1999 Mar;19(3):2373-9. doi: 10.1128/mcb.19.3.2373. Mol Cell Biol. 1999. PMID: 10022923 Free PMC article.
The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation.
Blickwedehl J, Olejniczak S, Cummings R, Sarvaiya N, Mantilla A, Chanan-Khan A, Pandita TK, Schmidt M, Thompson CB, Bangia N. Blickwedehl J, et al. Mol Cancer Res. 2012 Jul;10(7):937-44. doi: 10.1158/1541-7786.MCR-11-0493-T. Epub 2012 May 1. Mol Cancer Res. 2012. PMID: 22550082 Free PMC article.
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.
Sharma GG, So S, Gupta A, Kumar R, Cayrou C, Avvakumov N, Bhadra U, Pandita RK, Porteus MH, Chen DJ, Cote J, Pandita TK. Sharma GG, et al. Mol Cell Biol. 2010 Jul;30(14):3582-95. doi: 10.1128/MCB.01476-09. Epub 2010 May 17. Mol Cell Biol. 2010. PMID: 20479123 Free PMC article.
Negative Regulation of AKT Activation by BRCA1.
Xiang T, Ohashi A, Huang Y, Pandita TK, Ludwig T, Powell SN, Yang Q. Xiang T, et al. Cancer Res. 2008 Dec 15;68(24):10040-4. doi: 10.1158/0008-5472.CAN-08-3009. Cancer Res. 2008. PMID: 19074868 Free PMC article.
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