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Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles.
Chung J, Sahelijo N, Maruyama T, Hu J, Panitch R, Xia W, Mez J, Stein TD; Alzheimer's Disease Neuroimaging Initiative; Saykin AJ, Takeyama H, Farrer LA, Crane PK, Nho K, Jun GR. Chung J, et al. Among authors: panitch r. Alzheimers Dement. 2023 Nov;19(11):5173-5184. doi: 10.1002/alz.13069. Epub 2023 May 11. Alzheimers Dement. 2023. PMID: 37166019
Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease.
Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W; Alzheimer's Disease Genetics Consortium; Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Jun GR, et al. Among authors: panitch r. Alzheimers Dement. 2022 Nov;18(11):2042-2054. doi: 10.1002/alz.12607. Epub 2022 Feb 9. Alzheimers Dement. 2022. PMID: 35142023 Free PMC article.