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Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory.
Dimpfel W, Schombert L, Panossian AG. Dimpfel W, et al. Front Pharmacol. 2018 May 24;9:425. doi: 10.3389/fphar.2018.00425. eCollection 2018. Front Pharmacol. 2018. PMID: 29881348 Free PMC article.
R. rosea extract has a stimulating effect on the CNS, suggesting potential benefits on cognitive functions, memory, learning, and attention. ...A high degree of variation in the content of all active markers was observed. One extract from China lacked rosavin, and t …
R. rosea extract has a stimulating effect on the CNS, suggesting potential benefits on cognitive functions, memory, learning, and att …
Adaptogens in mental and behavioral disorders.
Panossian AG. Panossian AG. Psychiatr Clin North Am. 2013 Mar;36(1):49-64. doi: 10.1016/j.psc.2012.12.005. Psychiatr Clin North Am. 2013. PMID: 23538076 Review.
Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity.
Panossian A, Wikman G. Panossian A, et al. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. doi: 10.2174/157488409789375311. Epub 2009 Sep 1. Curr Clin Pharmacol. 2009. PMID: 19500070 Review.
The aim of this review article is to assess the level of scientific evidence presented by clinical trials of adaptogens in fatigue, and to provide a rationale at the molecular level for verified effects. ...Based on their efficacy in clinical studies, adaptogens can be def …
The aim of this review article is to assess the level of scientific evidence presented by clinical trials of adaptogens in fatigue, and to p …
Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells.
Panossian A, Seo EJ, Efferth T. Panossian A, et al. Phytomedicine. 2019 Jul;60:152881. doi: 10.1016/j.phymed.2019.152881. Epub 2019 Mar 10. Phytomedicine. 2019. PMID: 30987861 Free article.
Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells.
Seo EJ, Klauck SM, Efferth T, Panossian A. Seo EJ, et al. Among authors: panossian a. Phytomedicine. 2019 Mar 1;55:80-91. doi: 10.1016/j.phymed.2018.10.022. Epub 2018 Oct 19. Phytomedicine. 2019. PMID: 30668446
Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells.
Seo EJ, Klauck SM, Efferth T, Panossian A. Seo EJ, et al. Among authors: panossian a. Phytomedicine. 2019 Mar 15;56:246-260. doi: 10.1016/j.phymed.2018.11.011. Epub 2018 Nov 9. Phytomedicine. 2019. PMID: 30668345
Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.
Seo EJ, Efferth T, Panossian A. Seo EJ, et al. Among authors: panossian a. Phytomedicine. 2018 Nov 15;50:285-299. doi: 10.1016/j.phymed.2018.09.202. Epub 2018 Sep 20. Phytomedicine. 2018. PMID: 30466988 Free article.
Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology.
Panossian A, Seo EJ, Efferth T. Panossian A, et al. Phytomedicine. 2018 Nov 15;50:257-284. doi: 10.1016/j.phymed.2018.09.204. Epub 2018 Sep 20. Phytomedicine. 2018. PMID: 30466987
All samples tested showed significant effects on the expression of genes encoding neurohormones CRH, GNRH, UCN, G-protein-coupled and other transmembrane receptors TLR9, PRLR, CHRNE, GP1BA, PLXNA4, a ligand-dependent nuclear receptor RORA, transmembrane channels, transcrip …
All samples tested showed significant effects on the expression of genes encoding neurohormones CRH, GNRH, UCN, G-protein-coupled and other …
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