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Decreased phenylalanine uptake and turnover in patients with vitiligo.
Schallreuter KU, Chavan B, Rokos H, Hibberts N, Panske A, Wood JM. Schallreuter KU, et al. Among authors: panske a. Mol Genet Metab. 2005 Dec;86 Suppl 1:S27-33. doi: 10.1016/j.ymgme.2005.07.023. Epub 2005 Sep 6. Mol Genet Metab. 2005. PMID: 16143555 Review.
Basic evidence for epidermal H2O2/ONOO(-)-mediated oxidation/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB-UVB-activated pseudocatalase PC-KUS.
Schallreuter KU, Salem MA, Holtz S, Panske A. Schallreuter KU, et al. Among authors: panske a. FASEB J. 2013 Aug;27(8):3113-22. doi: 10.1096/fj.12-226779. Epub 2013 Apr 29. FASEB J. 2013. PMID: 23629861
Molecular evidence that halo in Sutton's naevus is not vitiligo.
Schallreuter KU, Kothari S, Elwary S, Rokos H, Hasse S, Panske A. Schallreuter KU, et al. Among authors: panske a. Arch Dermatol Res. 2003 Nov;295(6):223-8. doi: 10.1007/s00403-003-0427-2. Epub 2003 Oct 3. Arch Dermatol Res. 2003. PMID: 14530988
In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase.
Schallreuter KU, Moore J, Wood JM, Beazley WD, Gaze DC, Tobin DJ, Marshall HS, Panske A, Panzig E, Hibberts NA. Schallreuter KU, et al. Among authors: panske a. J Investig Dermatol Symp Proc. 1999 Sep;4(1):91-6. doi: 10.1038/sj.jidsp.5640189. J Investig Dermatol Symp Proc. 1999. PMID: 10537016 Review.
So far, four potential sources for epidermal H2O2 generation in vitiligo have been identified: (i) perturbed (6R)-L-erythro 5,6,7,8 tetrahydrobiopterin (6BH4) de novo synthesis/recycling/regulation; (ii) impaired catecholamine synthesis with increased monoamine oxidase A a …
So far, four potential sources for epidermal H2O2 generation in vitiligo have been identified: (i) perturbed (6R)-L-erythro 5,6,7,8 tetrahyd …
In vivo evidence for compromised phenylalanine metabolism in vitiligo.
Schallreuter KU, Zschiesche M, Moore J, Panske A, Hibberts NA, Herrmann FH, Metelmann HR, Sawatzki J. Schallreuter KU, et al. Among authors: panske a. Biochem Biophys Res Commun. 1998 Feb 13;243(2):395-9. doi: 10.1006/bbrc.1997.8107. Biochem Biophys Res Commun. 1998. PMID: 9480820
Additionally the peripheral blood L-phenylalanine turnover was determined over time after a single oral loading with L-phenylalanine in 32 patients (100 mg/kg body weight). ...Our results demonstrate for the first time a phenylalanine build-up in the involved epider …
Additionally the peripheral blood L-phenylalanine turnover was determined over time after a single oral loading with L-phenylalanine …
Serum selenium levels and blood glutathione peroxidase activities in vitiligo.
Beazley WD, Gaze D, Panske A, Panzig E, Schallreuter KU. Beazley WD, et al. Among authors: panske a. Br J Dermatol. 1999 Aug;141(2):301-3. doi: 10.1046/j.1365-2133.1999.02980.x. Br J Dermatol. 1999. PMID: 10468804
From basic research to the bedside: efficacy of topical treatment with pseudocatalase PC-KUS in 71 children with vitiligo.
Schallreuter KU, Krüger C, Würfel BA, Panske A, Wood JM. Schallreuter KU, et al. Among authors: panske a. Int J Dermatol. 2008 Jul;47(7):743-53. doi: 10.1111/j.1365-4632.2008.03660.x. Int J Dermatol. 2008. PMID: 18613887
Basic research confirms coexistence of acquired Blaschkolinear Vitiligo and acrofacial Vitiligo.
Schallreuter KU, Krüger C, Rokos H, Hasse S, Zothner C, Panske A. Schallreuter KU, et al. Among authors: panske a. Arch Dermatol Res. 2007 Aug;299(5-6):225-30. doi: 10.1007/s00403-007-0748-7. Epub 2007 Apr 3. Arch Dermatol Res. 2007. PMID: 17404749
Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo.
Schallreuter KU, Chiuchiarelli G, Cemeli E, Elwary SM, Gillbro JM, Spencer JD, Rokos H, Panske A, Chavan B, Wood JM, Anderson D. Schallreuter KU, et al. Among authors: panske a. J Invest Dermatol. 2006 May;126(5):1036-42. doi: 10.1038/sj.jid.5700257. J Invest Dermatol. 2006. PMID: 16528352 Free article.
Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed caucasian patients with vitiligo.
Schallreuter KU, Tobin DJ, Panske A. Schallreuter KU, et al. Among authors: panske a. Dermatology. 2002;204(3):194-201. doi: 10.1159/000057881. Dermatology. 2002. PMID: 12037447
RESULTS: There was no evidence for sun-related damage in the entire patient group, despite a significant number of positive cases with a history of sunburns in early childhood and continuous accumulation of epidermal H(2)O(2). ...Based on these results together with …
RESULTS: There was no evidence for sun-related damage in the entire patient group, despite a significant number of positive cases wit …
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