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IL-12 protects from psoriasiform skin inflammation.
Kulig P, Musiol S, Freiberger SN, Schreiner B, Gyülveszi G, Russo G, Pantelyushin S, Kishihara K, Alessandrini F, Kündig T, Sallusto F, Hofbauer GF, Haak S, Becher B. Kulig P, et al. Nat Commun. 2016 Nov 28;7:13466. doi: 10.1038/ncomms13466. Nat Commun. 2016. PMID: 27892456 Free PMC article.
Neutralization of the common p40-subunit of IL-12/23 in psoriasis patients has led to a breakthrough in the management of moderate to severe disease. ...We discover that IL-12 receptor signalling in keratinocytes initiates a protective transcriptional programme that limits …
Neutralization of the common p40-subunit of IL-12/23 in psoriasis patients has led to a breakthrough in the management of moderate to …
Aldara-induced psoriasis-like skin inflammation: isolation and characterization of cutaneous dendritic cells and innate lymphocytes.
Wohn CT, Pantelyushin S, Ober-Blöbaum JL, Clausen BE. Wohn CT, et al. Methods Mol Biol. 2014;1193:171-85. doi: 10.1007/978-1-4939-1212-4_16. Methods Mol Biol. 2014. PMID: 25151006
Psoriasis is a chronic auto-inflammatory skin disease of unknown etiology affecting millions of people worldwide. Dissecting the cellular networks and molecular signals promoting the development of psoriasis critically depends on appropriate animal models. Topical a …
Psoriasis is a chronic auto-inflammatory skin disease of unknown etiology affecting millions of people worldwide. Dissecting the cell …
Dermal IL-17-producing γδ T cells establish long-lived memory in the skin.
Hartwig T, Pantelyushin S, Croxford AL, Kulig P, Becher B. Hartwig T, et al. Eur J Immunol. 2015 Nov;45(11):3022-33. doi: 10.1002/eji.201545883. Epub 2015 Oct 19. Eur J Immunol. 2015. PMID: 26332438 Free article.
Using the alphabeta T-cell-independent Aldara psoriasis mouse model in combination with genetic fate-mapping and reporter systems, we identified a subset of gammadelta T cells in mice that is capable of establishing a long-lived memory population in the skin. ...In additio …
Using the alphabeta T-cell-independent Aldara psoriasis mouse model in combination with genetic fate-mapping and reporter systems, we …
Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice.
Pantelyushin S, Haak S, Ingold B, Kulig P, Heppner FL, Navarini AA, Becher B. Pantelyushin S, et al. J Clin Invest. 2012 Jun;122(6):2252-6. doi: 10.1172/JCI61862. Epub 2012 May 1. J Clin Invest. 2012. PMID: 22546855 Free PMC article.
Psoriasis is a common, relapsing inflammatory skin disease characterized by erythematous scaly plaques. ...Despite the availability of new effective drugs to treat psoriasis, the underlying mechanisms of pathogenesis are still poorly understood. Recent studies have …
Psoriasis is a common, relapsing inflammatory skin disease characterized by erythematous scaly plaques. ...Despite the availability o …
Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.
Wohn C, Ober-Blöbaum JL, Haak S, Pantelyushin S, Cheong C, Zahner SP, Onderwater S, Kant M, Weighardt H, Holzmann B, Reizis B, Becher B, Prens EP, Clausen BE. Wohn C, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10723-8. doi: 10.1073/pnas.1307569110. Epub 2013 Jun 10. Proc Natl Acad Sci U S A. 2013. PMID: 23754427 Free PMC article.
Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of Aldara cream containing the Toll-like receptor (TLR)7 agonist Imiquimod (IMQ) onto patients induces flares of psoriasis. ...These results suggest therapeutic targeting of IL-23 …
Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of Aldara cream containing the Toll-like recep …