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Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design.
Pantophlet R, Wilson IA, Burton DR. Pantophlet R, et al. J Virol. 2003 May;77(10):5889-901. doi: 10.1128/jvi.77.10.5889-5901.2003. J Virol. 2003. PMID: 12719582 Free PMC article.
In a first study, we found that four alanine substitutions on the perimeter of the so-called Phe-43 cavity of gp120 could reduce binding of weakly neutralizing CD4-binding site antibodies (R. Pantophlet, E. O. Saphire, P. Poignard, P. W. H. I. Parren, I. A. Wilson, …
In a first study, we found that four alanine substitutions on the perimeter of the so-called Phe-43 cavity of gp120 could reduce binding of …
Comparing antigenicity and immunogenicity of engineered gp120.
Selvarajah S, Puffer B, Pantophlet R, Law M, Doms RW, Burton DR. Selvarajah S, et al. Among authors: pantophlet r. J Virol. 2005 Oct;79(19):12148-63. doi: 10.1128/JVI.79.19.12148-12163.2005. J Virol. 2005. PMID: 16160142 Free PMC article.
GP120: target for neutralizing HIV-1 antibodies.
Pantophlet R, Burton DR. Pantophlet R, et al. Annu Rev Immunol. 2006;24:739-69. doi: 10.1146/annurev.immunol.24.021605.090557. Annu Rev Immunol. 2006. PMID: 16551265 Review.
Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.
Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. Saphire EO, et al. Among authors: pantophlet r. J Mol Biol. 2007 Jun 8;369(3):696-709. doi: 10.1016/j.jmb.2007.01.060. Epub 2007 Jan 27. J Mol Biol. 2007. PMID: 17445828 Free PMC article.
65 results