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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1934 1
1935 1
1936 1
1939 3
1940 6
1941 2
1942 6
1943 6
1944 3
1945 25
1946 33
1947 37
1948 45
1949 28
1950 38
1951 63
1952 62
1953 66
1954 77
1955 83
1956 86
1957 83
1958 59
1959 62
1960 59
1961 40
1962 41
1963 101
1964 79
1965 71
1966 79
1967 87
1968 81
1969 79
1970 89
1971 78
1972 81
1973 56
1974 60
1975 50
1976 49
1977 30
1978 39
1979 42
1980 45
1981 46
1982 31
1983 42
1984 48
1985 49
1986 46
1987 51
1988 53
1989 36
1990 42
1991 38
1992 35
1993 43
1994 18
1995 28
1996 39
1997 28
1998 25
1999 51
2000 49
2001 53
2002 50
2003 70
2004 83
2005 82
2006 94
2007 81
2008 50
2009 88
2010 104
2011 116
2012 122
2013 138
2014 119
2015 136
2016 142
2017 125
2018 149
2019 168
2020 173
2021 199
2022 241
2023 273
2024 257
2025 266
2026 98

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6,104 results

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Page 1
Biosynthesis of pantothenate.
Webb ME, Smith AG, Abell C. Webb ME, et al. Nat Prod Rep. 2004 Dec;21(6):695-721. doi: 10.1039/b316419p. Epub 2004 Oct 28. Nat Prod Rep. 2004. PMID: 15565250 Review.
Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. ...In addition a short survey of studies of the whole pathway, and a discussion of both the metabolism and the transport of …
Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteri …
Pantothenate biosynthesis in higher plants.
Coxon KM, Chakauya E, Ottenhof HH, Whitney HM, Blundell TL, Abell C, Smith AG. Coxon KM, et al. Biochem Soc Trans. 2005 Aug;33(Pt 4):743-6. doi: 10.1042/BST0330743. Biochem Soc Trans. 2005. PMID: 16042590 Review.
Pantothenate (vitamin B5) is a water-soluble vitamin essential for the synthesis of CoA and ACP (acyl-carrier protein, cofactors in energy yielding reactions including carbohydrate metabolism and fatty acid synthesis. Pantothenate is synthesized de novo by plants an …
Pantothenate (vitamin B5) is a water-soluble vitamin essential for the synthesis of CoA and ACP (acyl-carrier protein, cofactors in e …
Defective pantothenate metabolism and neurodegeneration.
Hayflick SJ. Hayflick SJ. Biochem Soc Trans. 2014 Aug;42(4):1063-8. doi: 10.1042/BST20140098. Biochem Soc Trans. 2014. PMID: 25110003 Free PMC article. Review.
Inborn errors of CoA (coenzyme A) biosynthesis lead to neurodegenerative disorders in humans. PKAN (pantothenate kinase-associated neurodegeneration) manifests with damage to brain, retina and testis and is caused by mutations in PANK2, the gene encoding the mitochondrial …
Inborn errors of CoA (coenzyme A) biosynthesis lead to neurodegenerative disorders in humans. PKAN (pantothenate kinase-associated ne …
Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.
Spry C, van Schalkwyk DA, Strauss E, Saliba KJ. Spry C, et al. Infect Disord Drug Targets. 2010 Jun;10(3):200-16. doi: 10.2174/187152610791163390. Infect Disord Drug Targets. 2010. PMID: 20334619 Review.
This requirement highlights the mechanisms involved in the utilization (uptake and metabolism) of pantothenate as potential targets for chemotherapeutic attack. Here we review the evidence demonstrating pantothenate to be an essential nutrient for P. falciparum and …
This requirement highlights the mechanisms involved in the utilization (uptake and metabolism) of pantothenate as potential targets f …
A therapeutic approach to pantothenate kinase associated neurodegeneration: a pilot study.
Pereira A, Fischinger Moura de Souza C, Álvarez-Córdoba M, Reche-López D, Sánchez-Alcázar JA. Pereira A, et al. Orphanet J Rare Dis. 2024 Nov 28;19(1):442. doi: 10.1186/s13023-024-03453-x. Orphanet J Rare Dis. 2024. PMID: 39609877 Free PMC article.
BACKGROUND: Neurodegeneration with brain iron accumulation (NBIA) is a group of genetic neurological disorders frequently associated with iron accumulation in the basal nuclei of the brain characterized by progressive spasticity, dystonia, muscle rigidity, neuropsychiatric sympto …
BACKGROUND: Neurodegeneration with brain iron accumulation (NBIA) is a group of genetic neurological disorders frequently associated with ir …
Pantothenate protects against obesity via brown adipose tissue activation.
Zhou H, Zhang H, Ye R, Yan C, Lin J, Huang Y, Jiang X, Yuan S, Chen L, Jiang R, Zheng K, Cheng Z, Zhang Z, Dong M, Jin W. Zhou H, et al. Am J Physiol Endocrinol Metab. 2022 Jul 1;323(1):E69-E79. doi: 10.1152/ajpendo.00293.2021. Epub 2022 May 16. Am J Physiol Endocrinol Metab. 2022. PMID: 35575231 Free article.
By screening a small-molecule compound library of drugs approved by the Food and Drug Administration, pantothenic acid was identified as being able to significantly upregulate the expression of uncoupling protein 1 (UCP1), a key thermogenic protein found in BAT. Pantoth …
By screening a small-molecule compound library of drugs approved by the Food and Drug Administration, pantothenic acid was identified …
Pantothenate auxotrophy of Methylobacterium spp. isolated from living plants.
Yoshida Y, Iguchi H, Sakai Y, Yurimoto H. Yoshida Y, et al. Biosci Biotechnol Biochem. 2019 Mar;83(3):569-577. doi: 10.1080/09168451.2018.1549935. Epub 2018 Nov 26. Biosci Biotechnol Biochem. 2019. PMID: 30475153 Free article.
OR01 demonstrated that this strain cannot synthesize beta-alanine, one of the precursors of pantothenate. beta-alanine and several precursors of pantothenate restored the growth of Methylobacterium sp. ...These results suggest that pantothenate-auxotrophic PP …
OR01 demonstrated that this strain cannot synthesize beta-alanine, one of the precursors of pantothenate. beta-alanine and several pr …
Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii.
Lunghi M, Kloehn J, Krishnan A, Varesio E, Vadas O, Soldati-Favre D. Lunghi M, et al. Nat Commun. 2022 Jan 17;13(1):345. doi: 10.1038/s41467-022-27996-4. Nat Commun. 2022. PMID: 35039477 Free PMC article.
While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like most plants, fungi and bacteria, parasites of the coccidian subgroup of Apicomplexa, including the human pathogen Toxoplasma gondii, possess al …
While all organisms synthesize CoA, many, including humans, are unable to produce its precursor, pantothenate. Intriguingly, like mos …
Optimum nutrition: thiamin, biotin and pantothenate.
Bender DA. Bender DA. Proc Nutr Soc. 1999 May;58(2):427-33. doi: 10.1017/s0029665199000567. Proc Nutr Soc. 1999. PMID: 10466187 Review.
Plasma triacylglycerol and nonesterified fatty acids are moderately elevated in pantothenic acid deficiency. However, this is unlikely to be useful in assessing pantothenate status, since again, other more common factors affect plasma lipids. To date there are no bi …
Plasma triacylglycerol and nonesterified fatty acids are moderately elevated in pantothenic acid deficiency. However, this is unlikel …
6,104 results