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Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers.
Liu DT, Tibbs GR, Paoletti P, Siegelbaum SA. Liu DT, et al. Among authors: paoletti p. Neuron. 1998 Jul;21(1):235-48. doi: 10.1016/s0896-6273(00)80530-9. Neuron. 1998. PMID: 9697867
Glycine-independent and subunit-specific potentiation of NMDA responses by extracellular Mg2+.
Paoletti P, Neyton J, Ascher P. Paoletti P, et al. Neuron. 1995 Nov;15(5):1109-20. doi: 10.1016/0896-6273(95)90099-3. Neuron. 1995. PMID: 7576654
C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating.
Paoletti P, Young EC, Siegelbaum SA. Paoletti P, et al. J Gen Physiol. 1999 Jan;113(1):17-34. doi: 10.1085/jgp.113.1.17. J Gen Physiol. 1999. PMID: 9874685 Free PMC article.
Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.
Paoletti P, Perin-Dureau F, Fayyazuddin A, Le Goff A, Callebaut I, Neyton J. Paoletti P, et al. Neuron. 2000 Dec;28(3):911-25. doi: 10.1016/s0896-6273(00)00163-x. Neuron. 2000. PMID: 11163276
Modulation of triheteromeric NMDA receptors by N-terminal domain ligands.
Hatton CJ, Paoletti P. Hatton CJ, et al. Among authors: paoletti p. Neuron. 2005 Apr 21;46(2):261-74. doi: 10.1016/j.neuron.2005.03.005. Neuron. 2005. PMID: 15848804
Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition.
Gielen M, Le Goff A, Stroebel D, Johnson JW, Neyton J, Paoletti P. Gielen M, et al. Among authors: paoletti p. Neuron. 2008 Jan 10;57(1):80-93. doi: 10.1016/j.neuron.2007.11.021. Neuron. 2008. PMID: 18184566 Free PMC article.
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Hackos DH, Lupardus PJ, Grand T, Chen Y, Wang TM, Reynen P, Gustafson A, Wallweber HJ, Volgraf M, Sellers BD, Schwarz JB, Paoletti P, Sheng M, Zhou Q, Hanson JE. Hackos DH, et al. Among authors: paoletti p. Neuron. 2016 Mar 2;89(5):983-99. doi: 10.1016/j.neuron.2016.01.016. Epub 2016 Feb 11. Neuron. 2016. PMID: 26875626
Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.
Malherbe P, Mutel V, Broger C, Perin-Dureau F, Kemp JA, Neyton J, Paoletti P, Kew JN. Malherbe P, et al. Among authors: paoletti p. J Pharmacol Exp Ther. 2003 Dec;307(3):897-905. doi: 10.1124/jpet.103.056291. Epub 2003 Oct 8. J Pharmacol Exp Ther. 2003. PMID: 14534359
A startling role for synaptic zinc.
Kay AR, Neyton J, Paoletti P. Kay AR, et al. Among authors: paoletti p. Neuron. 2006 Nov 22;52(4):572-4. doi: 10.1016/j.neuron.2006.11.007. Neuron. 2006. PMID: 17114041 Review.
Zinc at glutamatergic synapses.
Paoletti P, Vergnano AM, Barbour B, Casado M. Paoletti P, et al. Neuroscience. 2009 Jan 12;158(1):126-36. doi: 10.1016/j.neuroscience.2008.01.061. Epub 2008 Feb 15. Neuroscience. 2009. PMID: 18353558 Review.
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