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Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants.
Varvarigou A, Bardin CL, Beharry K, Chemtob S, Papageorgiou A, Aranda JV. Varvarigou A, et al. JAMA. 1996 Feb 21;275(7):539-44. JAMA. 1996. PMID: 8606475 Clinical Trial.
PATIENTS: Thirty-four premature newborn infants born from February to August 1993 with a mean birth weight of 913 g (range, 565 to 1460 g) and gestational age of 26.9 weeks (range, 22.4 to 31.0). ...The incidence of PDA and other variables did not differ between patients w …
PATIENTS: Thirty-four premature newborn infants born from February to August 1993 with a mean birth weight of 913 g (range, 565 to 14 …
Efficacy of sequential early systemic and inhaled corticosteroid therapy in the prevention of chronic lung disease of prematurity.
Kovács L, Davis GM, Faucher D, Papageorgiou A. Kovács L, et al. Acta Paediatr. 1998 Jul;87(7):792-8. doi: 10.1080/080352598750013905. Acta Paediatr. 1998. PMID: 9722255 Clinical Trial.

In order to assess the efficacy of a combination of systemic and nebulized corticosteroids in reducing the incidence and severity of chronic lung disease (CLD) in very low birthweight (VLBW) infants, 60 ventilator-dependent infants < or = 1500 g were randomly assigned t

In order to assess the efficacy of a combination of systemic and nebulized corticosteroids in reducing the incidence and severity of …
Outcome of small-for-gestational age and appropriate-for-gestational age infants born before 27 weeks of gestation.
Bardin C, Zelkowitz P, Papageorgiou A. Bardin C, et al. Pediatrics. 1997 Aug;100(2):E4. doi: 10.1542/peds.100.2.e4. Pediatrics. 1997. PMID: 9233975
Despite a similar rate of respiratory distress syndrome (50%), the SGA infants had a greater rate of failure of indomethacin treatment for PDA closure (54% vs 32% for AGA), a higher risk for CLD defined as a need for supplementary oxygen at 36 weeks (6 …
Despite a similar rate of respiratory distress syndrome (50%), the SGA infants had a greater rate of failure of indomethacin t …
Gastrointestinal absorption of doxapram in neonates.
Bairam A, Akramoff-Gershan L, Beharry K, Laudignon N, Papageorgiou A, Aranda JV. Bairam A, et al. Am J Perinatol. 1991 Mar;8(2):110-3. doi: 10.1055/s-2007-999357. Am J Perinatol. 1991. PMID: 2006935
Doxapram was administered orally to six premature babies (3 males, 3 females) with refractory apnea at a mean gestational age of 29 +/- 2.3 weeks, mean birthweight of 1142 +/- 359 gm and a mean postnatal age of 24 days. They received 12, 24, and 36 mg/kg/6 hr on day …
Doxapram was administered orally to six premature babies (3 males, 3 females) with refractory apnea at a mean gestational age of 29 + …
Spectrum of oxygen dependency in surviving infants weighing 600 to 1000 grams: decreased incidence of severe chronic lung disease.
Le Guennec JC, Rufai M, Papageorgiou A. Le Guennec JC, et al. Am J Perinatol. 1993 Jul;10(4):292-6. doi: 10.1055/s-2007-994743. Am J Perinatol. 1993. PMID: 8397565
Incidence and factors predisposing to chronic lung disease (CLD) were studied in a group of 110 infants still alive at the age of 1 year (69.2%) of an initial group of 159 infants born with a birthweight between 600 and 1000 gm from 1983 to 1988. ...Oxygen dependenc …
Incidence and factors predisposing to chronic lung disease (CLD) were studied in a group of 110 infants still alive at the age of 1 y …
Outcome at 5 years of age of SGA and AGA infants born less than 28 weeks of gestation.
Bardin C, Piuze G, Papageorgiou A. Bardin C, et al. Semin Perinatol. 2004 Aug;28(4):288-94. doi: 10.1053/j.semperi.2004.08.006. Semin Perinatol. 2004. PMID: 15565789
The method used was a longitudinal follow-up of a cohort of 37 dyads of SGA and AGA infants matched by gestational age (GA), gender, and date of delivery. ...We conclude that the combination of severe prematurity and intrauterine growth retardation constitutes a
The method used was a longitudinal follow-up of a cohort of 37 dyads of SGA and AGA infants matched by gestational age (GA), g …
Review of the antenatal and postnatal use of steroids.
Bartholomew J, Kovacs L, Papageorgiou A. Bartholomew J, et al. Indian J Pediatr. 2014 May;81(5):466-72. doi: 10.1007/s12098-014-1376-9. Epub 2014 Mar 30. Indian J Pediatr. 2014. PMID: 24682835 Review.
Hydrocortisone appears to be a good alternative, with reassuring long-term evaluations thus far....
Hydrocortisone appears to be a good alternative, with reassuring long-term evaluations thus far....
Reduction of mortality, morbidity, and respiratory distress syndrome in infants weighing less than 1,000 grams by treatment with betamethasone and ritodrine.
Papageorgiou AN, Doray JL, Ardila R, Kunos I. Papageorgiou AN, et al. Pediatrics. 1989 Apr;83(4):493-7. Pediatrics. 1989. PMID: 2927987
Our data suggest that in infants weighing less than 1,000 g, control of labor with ritodrine for a minimum of 24 hours and administration of betamethasone can reduce significantly not only the incidence of respiratory distress syndrome but also mortality and morbidity....
Our data suggest that in infants weighing less than 1,000 g, control of labor with ritodrine for a minimum of 24 hours and administra …
Plasma homocysteine concentrations of preterm infants.
Hongsprabhas P, Saboohi F, Aranda JV, Bardin CL, Kovacs LB, Papageorgiou AN, Hoffer LJ. Hongsprabhas P, et al. Biol Neonate. 1999 Aug;76(2):65-71. doi: 10.1159/000014143. Biol Neonate. 1999. PMID: 10393990
We measured plasma total homocysteine concentrations of 9 preterm infants (gestational age 23-31 weeks) within 48 h of birth and over the subsequent 14 days of life, and 4 term infants (gestational age 36-39 weeks) on a single occasion within 72 h of birth. ...
We measured plasma total homocysteine concentrations of 9 preterm infants (gestational age 23-31 weeks) within 48 h of birth and over the su …
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