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The "Parkinsonian heart": from novel vistas to advanced therapeutic approaches in Parkinson's disease.
Fornai F, Ruffoli R, Soldani P, Ruggieri S, Paparelli A. Fornai F, et al. Curr Med Chem. 2007;14(23):2421-8. doi: 10.2174/092986707782023631. Curr Med Chem. 2007. PMID: 17979697 Review.
This is characterized by a severe loss of the physiological noradrenergic innervation and a slight impairment of central autonomic control and it is often characterized by drug-induced morpho-functional alterations. ...These effects recently became a major is …
This is characterized by a severe loss of the physiological noradrenergic innervation and a slight impairment of central auton …
Does autophagy worsen or improve the survival of dopaminergic neurons?
Pasquali L, Ruggieri S, Murri L, Paparelli A, Fornai F. Pasquali L, et al. Parkinsonism Relat Disord. 2009 Dec;15 Suppl 4:S24-7. doi: 10.1016/S1353-8020(09)70830-2. Parkinsonism Relat Disord. 2009. PMID: 20123552 Review.
Moreover, a variety of inherited forms of Parkinson's disease are characterized by mutated proteins that belong to the autophagy pathway. ...
Moreover, a variety of inherited forms of Parkinson's disease are characterized by mutated proteins that belong to the autophagy path …
The role of autophagy on the survival of dopamine neurons.
Isidoro C, Biagioni F, Giorgi FS, Fulceri F, Paparelli A, Fornai F. Isidoro C, et al. Curr Top Med Chem. 2009;9(10):869-79. Curr Top Med Chem. 2009. PMID: 19754403 Review.
Although autophagy has been known for a long time, its involvement in the pathogenesis of neurodegenerative diseases has been investigated only recently. ...In the present manuscript, after describing the general molecular and cellular features of ATG, we give a sho …
Although autophagy has been known for a long time, its involvement in the pathogenesis of neurodegenerative diseases has been investi …
Intermittent Dopaminergic stimulation causes behavioral sensitization in the addicted brain and parkinsonism.
Fornai F, Biagioni F, Fulceri F, Murri L, Ruggieri S, Paparelli A. Fornai F, et al. Int Rev Neurobiol. 2009;88:371-98. doi: 10.1016/S0074-7742(09)88013-6. Int Rev Neurobiol. 2009. PMID: 19897084 Review.
While such a therapy produces an increase in synaptic and nonsynaptic DA, which replace the neurotransmitter deficiency, peaks of extracellular DA in the course of disease progression produce abnormal involuntary movements related to behavioral sensitization. Methamphetami …
While such a therapy produces an increase in synaptic and nonsynaptic DA, which replace the neurotransmitter deficiency, peaks of ext …
Mechanisms involved in the formation of dopamine-induced intracellular bodies within striatal neurons.
Lazzeri G, Lenzi P, Busceti CL, Ferrucci M, Falleni A, Bruno V, Paparelli A, Fornai F. Lazzeri G, et al. J Neurochem. 2007 Jun;101(5):1414-27. doi: 10.1111/j.1471-4159.2006.04429.x. Epub 2007 Feb 5. J Neurochem. 2007. PMID: 17286589
These consist of neuronal bodies staining for a variety of antigens belonging to the ubiquitin-proteasome pathway. The formation of these intracellular bodies both in the substantia nigra and PC12 cells depends on the presence of endogenous DA. ...
These consist of neuronal bodies staining for a variety of antigens belonging to the ubiquitin-proteasome pathway. The formation of t …
Role of autophagy during methamphetamine neurotoxicity.
Pasquali L, Lazzeri G, Isidoro C, Ruggieri S, Paparelli A, Fornai F. Pasquali L, et al. Ann N Y Acad Sci. 2008 Oct;1139:191-6. doi: 10.1196/annals.1432.016. Ann N Y Acad Sci. 2008. PMID: 18991864
Our preliminary findings rule out a detrimental role for autophagy; this represents the first step in understanding the consequence of activation of autophagy in methamphetamine toxicity....
Our preliminary findings rule out a detrimental role for autophagy; this represents the first step in understanding the consequence o …
Activation of brain metabolism and fos during limbic seizures: the role of locus coeruleus.
Giorgi FS, Blandini F, Cantafora E, Biagioni F, Armentero MT, Pasquali L, Orzi F, Murri L, Paparelli A, Fornai F. Giorgi FS, et al. Neurobiol Dis. 2008 Jun;30(3):388-99. doi: 10.1016/j.nbd.2008.02.008. Epub 2008 Mar 6. Neurobiol Dis. 2008. PMID: 18395460
In DSP-4+bicuculline rats there is an overall lower expression of the protein as compared with the cyclothiazide+bicuculline or bicuculline alone groups; even more, such a difference co-exists with an higher lCMRglc in the DSP-4+bicuculline-treated rats in some regions, as …
In DSP-4+bicuculline rats there is an overall lower expression of the protein as compared with the cyclothiazide+bicuculline or bicuculline …
Transmission of prions within the gut and towards the central nervous system.
Natale G, Ferrucci M, Lazzeri G, Paparelli A, Fornai F. Natale G, et al. Prion. 2011 Jul-Sep;5(3):142-9. doi: 10.4161/pri.5.3.16328. Epub 2011 Jul 1. Prion. 2011. PMID: 21814041 Free PMC article. Review.
The prion protein is a glycoprotein characterized by a folded α-helical structure that, under pathological conditions, misfolds and aggregates into its infectious isoform as β-sheet rich amyloidic deposits. ...In particular, a special emphasis is posed on the …
The prion protein is a glycoprotein characterized by a folded α-helical structure that, under pathological conditions, misfold …
MDMA (ecstasy) enhances loud noise-induced morphofunctional alterations in heart and adrenal gland.
Fulceri F, Ferrucci M, Lenzi P, Soldani P, Bartalucci A, Paparelli A, Gesi M. Fulceri F, et al. Microsc Res Tech. 2011 Sep;74(9):874-87. doi: 10.1002/jemt.20971. Epub 2010 Dec 16. Microsc Res Tech. 2011. PMID: 23939676 Review.
Noise is an environmental stressor increasingly more present in modern life and, in particular, in a variety of recreational contexts. ...For this reason, MDMA is defined as a club drug--as its intake by young people often occurs in association with other factors, s …
Noise is an environmental stressor increasingly more present in modern life and, in particular, in a variety of recreational contexts …
MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut.
Natale G, Kastsiushenka O, Fulceri F, Ruggieri S, Paparelli A, Fornai F. Natale G, et al. Brain Res. 2010 Oct 8;1355:195-206. doi: 10.1016/j.brainres.2010.07.076. Epub 2010 Aug 5. Brain Res. 2010. PMID: 20691673
Despite such a high prevalence of gut impairment in PD, the molecular mechanisms remain poorly investigated. This is also due to the scarcity of experimental studies. ...These functional, biochemical, and morphological findings extend the PD-mimicking effects of MPTP to GI …
Despite such a high prevalence of gut impairment in PD, the molecular mechanisms remain poorly investigated. This is also due to the …
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