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The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
Elder DJ, Halton DE, Playle LC, Paraskeva C. Elder DJ, et al. Among authors: paraskeva c. Int J Cancer. 2002 May 20;99(3):323-7. doi: 10.1002/ijc.10330. Int J Cancer. 2002. PMID: 11992399
miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance.
Zhang L, Pickard K, Jenei V, Bullock MD, Bruce A, Mitter R, Kelly G, Paraskeva C, Strefford J, Primrose J, Thomas GJ, Packham G, Mirnezami AH. Zhang L, et al. Among authors: paraskeva c. Cancer Res. 2013 Nov 1;73(21):6435-47. doi: 10.1158/0008-5472.CAN-12-3308. Epub 2013 Aug 15. Cancer Res. 2013. PMID: 23950211 Free PMC article.
BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling.
Urban BC, Collard TJ, Eagle CJ, Southern SL, Greenhough A, Hamdollah-Zadeh M, Ghosh A, Poulsom R, Paraskeva C, Silver A, Williams AC. Urban BC, et al. Among authors: paraskeva c. Gut. 2016 Jul;65(7):1151-64. doi: 10.1136/gutjnl-2014-308270. Epub 2015 Jun 1. Gut. 2016. PMID: 26033966 Free PMC article.
TGF-β1 signalling, connecting aberrant inflammation and colorectal tumorigenesis.
Skeen VR, Paterson I, Paraskeva C, Williams AC. Skeen VR, et al. Among authors: paraskeva c. Curr Pharm Des. 2012;18(26):3874-88. doi: 10.2174/138161212802083734. Curr Pharm Des. 2012. PMID: 22632753 Review.
The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.
Patsos HA, Greenhough A, Hicks DJ, Al Kharusi M, Collard TJ, Lane JD, Paraskeva C, Williams AC. Patsos HA, et al. Among authors: paraskeva c. Int J Oncol. 2010 Jul;37(1):187-93. doi: 10.3892/ijo_00000666. Int J Oncol. 2010. PMID: 20514410
HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Moore AE, Greenhough A, Roberts HR, Hicks DJ, Patsos HA, Williams AC, Paraskeva C. Moore AE, et al. Among authors: paraskeva c. Carcinogenesis. 2009 Oct;30(10):1796-804. doi: 10.1093/carcin/bgp183. Epub 2009 Jul 28. Carcinogenesis. 2009. PMID: 19638428
O-glycan inhibitors generate aryl-glycans, induce apoptosis and lead to growth inhibition in colorectal cancer cell lines.
Patsos G, Hebbe-Viton V, Robbe-Masselot C, Masselot D, San Martin R, Greenwood R, Paraskeva C, Klein A, Graessmann M, Michalski JC, Gallagher T, Corfield A. Patsos G, et al. Among authors: paraskeva c. Glycobiology. 2009 Apr;19(4):382-98. doi: 10.1093/glycob/cwn149. Epub 2009 Jan 3. Glycobiology. 2009. PMID: 19122213
The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
Greenhough A, Patsos HA, Williams AC, Paraskeva C. Greenhough A, et al. Among authors: paraskeva c. Int J Cancer. 2007 Nov 15;121(10):2172-80. doi: 10.1002/ijc.22917. Int J Cancer. 2007. PMID: 17583570
Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer.
Chell S, Kaidi A, Williams AC, Paraskeva C. Chell S, et al. Among authors: paraskeva c. Biochim Biophys Acta. 2006 Aug;1766(1):104-19. doi: 10.1016/j.bbcan.2006.05.002. Epub 2006 May 23. Biochim Biophys Acta. 2006. PMID: 16859832 Review.
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
Kaidi A, Qualtrough D, Williams AC, Paraskeva C. Kaidi A, et al. Among authors: paraskeva c. Cancer Res. 2006 Jul 1;66(13):6683-91. doi: 10.1158/0008-5472.CAN-06-0425. Cancer Res. 2006. PMID: 16818642
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