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2007 1
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130 results

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Page 1
Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications.
Vadovics M, Zhao W, Daley EF, Lam K, Daly O, Rashid K, Lee HR, Schreiner P, Lundgreen KA, Gaudette BT, Shuvaev VV, Arguiri E, Muramatsu H, Sárközy A, Mdluli T, Xu J, Han X, De Luna N, Castaño D, Bettini E, Ábrahám E, Lipinszki Z, Carlucci G, Bansode AH, Nguyen K, Le TM, Luu T, Muzykantov VR, Bates P, Allman D, Mitchell MJ, Locci M, Radu CG, Heyes J, Pardi N. Vadovics M, et al. Among authors: pardi n. Nat Nanotechnol. 2025 Jun 23. doi: 10.1038/s41565-025-01958-5. Online ahead of print. Nat Nanotechnol. 2025. PMID: 40550975
mRNA-LNP vaccines against Hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models.
Limeres MJ, Gambaro R, Svensson M, Fraude-El Ghazi S, Pretsch L, Frank D, Islan GA, Berti IR, Bros M, Tam YK, Muramatsu H, Pardi N, Gehring S, Cacicedo ML. Limeres MJ, et al. Among authors: pardi n. Mol Ther. 2025 Jun 14:S1525-0016(25)00478-2. doi: 10.1016/j.ymthe.2025.06.027. Online ahead of print. Mol Ther. 2025. PMID: 40518670 Free article.
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates.
Malewana RD, Stalls V, May A, Lu X, Martinez DR, Schäfer A, Li D, Barr M, Sutherland LL, Lee E, Parks R, Beck WE, Newman A, Bock KW, Minai M, Nagata BM, DeMarco CT, Denny TN, Oguin TH 3rd, Rountree W, Wang Y, Mansouri K, Edwards RJ, Smith L, Sempowski GD, Eaton A, Muramatsu H, Henderson R, Tam Y, Barbosa C, Tang J, Cain DW, Santra S, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Montefiori DC, Pardi N, Weissman D, Baric RS, Acharya P, Haynes BF, Saunders KO. Malewana RD, et al. Among authors: pardi n. Sci Transl Med. 2025 Jun 11;17(802):eadn5651. doi: 10.1126/scitranslmed.adn5651. Epub 2025 Jun 11. Sci Transl Med. 2025. PMID: 40498855
Clinical advances in gene, cell, and RNA therapies.
Milone MC, Mansilla-Soto J, Pardi N, George LA, Byrne BJ, Herzog RW. Milone MC, et al. Among authors: pardi n. Mol Ther. 2025 Jun 4;33(6):2311. doi: 10.1016/j.ymthe.2025.05.012. Epub 2025 May 20. Mol Ther. 2025. PMID: 40398418 No abstract available.
Treatment of a metabolic liver disease in mice with a transient prime editing approach.
Rothgangl T, Tálas A, Ioannidi EI, Weber Y, Böck D, Matsushita M, Villiger EA, Schmidheini L, Moon WJ, Lin PJC, Fan SHY, Marquart KF, Schwerdel C, Rimann N, Faccin E, Villiger L, Muramatsu H, Vadovics M, Cremonesi A, Kulcsár PI, Thöny B, Kopf M, Häberle J, Pardi N, Tam YK, Schwank G. Rothgangl T, et al. Among authors: pardi n. Nat Biomed Eng. 2025 May 20. doi: 10.1038/s41551-025-01399-4. Online ahead of print. Nat Biomed Eng. 2025. PMID: 40394220
BMP-2 mRNA-transfected BMSCs promote superior calvarial bone regeneration.
Surisaeng T, Wisitrasameewong W, Champaiboon C, Sa-Ard-Iam N, Chanamuangkon T, Thongnuek P, Tam YK, Muramatsu H, Weissman D, Pardi N, Pichyangkul S, Mahanonda R. Surisaeng T, et al. Among authors: pardi n. Sci Rep. 2025 Apr 29;15(1):15022. doi: 10.1038/s41598-025-99979-6. Sci Rep. 2025. PMID: 40301548 Free PMC article.
Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity.
Tursi NJ, Tiwari S, Bedanova N, Kannan T, Parzych E, Okba N, Liaw K, Sárközy A, Livingston C, Trullen MI, Gary EN, Vadovics M, Laenger N, Londregan J, Khan MS, Omo-Lamai S, Muramatsu H, Blatney K, Hojecki C, Machado V, Maricic I, Smith TRF, Humeau LM, Patel A, Kossenkov A, Brenner JS, Allman D, Krammer F, Pardi N, Weiner DB. Tursi NJ, et al. Among authors: pardi n. Cell Rep Med. 2025 Apr 15;6(4):102035. doi: 10.1016/j.xcrm.2025.102035. Epub 2025 Mar 21. Cell Rep Med. 2025. PMID: 40120578 Free PMC article.
130 results