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The blockade of immune checkpoints in cancer immunotherapy.
Pardoll DM. Pardoll DM. Nat Rev Cancer. 2012 Mar 22;12(4):252-64. doi: 10.1038/nrc3239. Nat Rev Cancer. 2012. PMID: 22437870 Free PMC article. Review.
Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system.
Maxwell R, Luksik AS, Garzon-Muvdi T, Hung AL, Kim ES, Wu A, Xia Y, Belcaid Z, Gorelick N, Choi J, Theodros D, Jackson CM, Mathios D, Ye X, Tran PT, Redmond KJ, Brem H, Pardoll DM, Kleinberg LR, Lim M. Maxwell R, et al. Among authors: pardoll dm. Oncoimmunology. 2018 Sep 6;7(12):e1500108. doi: 10.1080/2162402X.2018.1500108. eCollection 2018. Oncoimmunology. 2018. PMID: 30524891 Free PMC article.
Neoadjuvant PD-1 Blockade in Resectable Lung Cancer.
Forde PM, Chaft JE, Smith KN, Anagnostou V, Cottrell TR, Hellmann MD, Zahurak M, Yang SC, Jones DR, Broderick S, Battafarano RJ, Velez MJ, Rekhtman N, Olah Z, Naidoo J, Marrone KA, Verde F, Guo H, Zhang J, Caushi JX, Chan HY, Sidhom JW, Scharpf RB, White J, Gabrielson E, Wang H, Rosner GL, Rusch V, Wolchok JD, Merghoub T, Taube JM, Velculescu VE, Topalian SL, Brahmer JR, Pardoll DM. Forde PM, et al. Among authors: pardoll dm. N Engl J Med. 2018 May 24;378(21):1976-1986. doi: 10.1056/NEJMoa1716078. Epub 2018 Apr 16. N Engl J Med. 2018. PMID: 29658848 Free PMC article. Clinical Trial.
Tumor Regression and Allograft Rejection after Administration of Anti-PD-1.
Lipson EJ, Bagnasco SM, Moore J Jr, Jang S, Patel MJ, Zachary AA, Pardoll DM, Taube JM, Drake CG. Lipson EJ, et al. Among authors: pardoll dm. N Engl J Med. 2016 Mar 3;374(9):896-8. doi: 10.1056/NEJMc1509268. N Engl J Med. 2016. PMID: 26962927 Free PMC article. No abstract available.
PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.
Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP, Friedlander PA, Kluger HM, Kohrt HE, Lundgren L, Margolin K, Mitchell A, Olencki T, Pardoll DM, Reddy SA, Shantha EM, Sharfman WH, Sharon E, Shemanski LR, Shinohara MM, Sunshine JC, Taube JM, Thompson JA, Townson SM, Yearley JH, Topalian SL, Cheever MA. Nghiem PT, et al. Among authors: pardoll dm. N Engl J Med. 2016 Jun 30;374(26):2542-52. doi: 10.1056/NEJMoa1603702. Epub 2016 Apr 19. N Engl J Med. 2016. PMID: 27093365 Free PMC article. Clinical Trial.
Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade: A Systematic Review and Meta-analysis.
Lu S, Stein JE, Rimm DL, Wang DW, Bell JM, Johnson DB, Sosman JA, Schalper KA, Anders RA, Wang H, Hoyt C, Pardoll DM, Danilova L, Taube JM. Lu S, et al. Among authors: pardoll dm. JAMA Oncol. 2019 Jul 18;5(8):1195-204. doi: 10.1001/jamaoncol.2019.1549. Online ahead of print. JAMA Oncol. 2019. PMID: 31318407 Free PMC article.
Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.
Garzon-Muvdi T, Theodros D, Luksik AS, Maxwell R, Kim E, Jackson CM, Belcaid Z, Ganguly S, Tyler B, Brem H, Pardoll DM, Lim M. Garzon-Muvdi T, et al. Among authors: pardoll dm. Oncotarget. 2018 Apr 17;9(29):20681-20697. doi: 10.18632/oncotarget.25061. eCollection 2018 Apr 17. Oncotarget. 2018. PMID: 29755681 Free PMC article.
Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1.
Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, Bartlett BR, Aulakh LK, Sidhom JW, Zhu Q, Sears CL, Cope L, Sharfman WH, Thompson ED, Riemer J, Marrone KA, Naidoo J, Velculescu VE, Forde PM, Vogelstein B, Kinzler KW, Papadopoulos N, Durham JN, Wang H, Le DT, Justesen S, Taube JM, Diaz LA Jr, Brahmer JR, Pardoll DM, Anders RA, Housseau F. Smith KN, et al. Among authors: pardoll dm. J Immunother Cancer. 2019 Mar 6;7(1):63. doi: 10.1186/s40425-019-0547-7. J Immunother Cancer. 2019. PMID: 30841906 Free PMC article.
The intestinal microbiome influences checkpoint blockade.
Sears CL, Pardoll DM. Sears CL, et al. Among authors: pardoll dm. Nat Med. 2018 Mar 6;24(3):254-255. doi: 10.1038/nm.4511. Nat Med. 2018. PMID: 29509750 Free PMC article.
Regulatory T-cell Response to Enterotoxigenic Bacteroides fragilis Colonization Triggers IL17-Dependent Colon Carcinogenesis.
Geis AL, Fan H, Wu X, Wu S, Huso DL, Wolfe JL, Sears CL, Pardoll DM, Housseau F. Geis AL, et al. Among authors: pardoll dm. Cancer Discov. 2015 Oct;5(10):1098-109. doi: 10.1158/2159-8290.CD-15-0447. Epub 2015 Jul 22. Cancer Discov. 2015. PMID: 26201900 Free PMC article.
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